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Apob
Gene Detail
Symbol

Name
ID
Apob
apolipoprotein B
MGI:88052
Synonyms
apob-100, apob-48
Feature Type
protein coding gene
Genetic Map
Chromosome 12
3.53 cM
Detailed Genetic Map ± 1 cM


Mapping data(26)
Sequence Map
Chr12:7977648-8016835 bp, + strand
From VEGA annotation of GRCm38

  39188 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:328  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: APOB
Gene Tree: Apob

Human
homologs
APOB, apolipoprotein B
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 338
neXtProt AC: NX_P04114

Human Synonyms: FLDB, LDLCQ4

Human Chr (Location): 2p24-p23; chr2:20999218-21044073 (-)  GRCh38.p2

Disease Associations: (2) Diseases Associated with Human APOB

Mutations,
alleles, and
phenotypes
All mutations/alleles(15) : Targeted(13) Transgenic(2)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygous null mutants usually die by midgestation and longer survivors exhibit exencephaly. Heterozygotes show reduced plasma cholesterol and apolipoprotein levels. Single isoform B100 and B48 null mutants are viable.
 
Human Diseases Modeled in Mice Using Apob (2)    Mutations Annotated to Human Diseases (9)    Phenotype Images(3)
Interactions
Apob interacts with 166 markers (Mir7-1, Mir9-1, Mir9-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (79 annotations)
Process artery morphogenesis, cholesterol efflux, ...
Component actin cytoskeleton, chylomicron, ...
Function cholesterol transporter activity, heparin binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (18 records)
Data Summary: Results (67)    Tissues (15)    Images (26)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 43
Western blot 5
RT-PCR 7
RNase protection 12
cDNA source data(53)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase apob ; ZFIN apoba, apobb.1, LOC100330435    NEW 
Molecular
reagents
All nucleic(65) Genomic(4) cDNA(59) Primer pair(2)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000035465 (Evidence)
Ensembl Gene Model ENSMUSG00000020609 (Evidence)
Entrez Gene 238055 (Evidence)
UniGene 221239
DFCI TC1597783, TC1599362, TC1605478, TC1612818, TC1649586, TC1658823
DoTS DT.492380, DT.91320976, DT.91325257, DT.94345476
NIA Mouse Gene Index U013736
Consensus CDS Project CCDS49022.1
International Mouse Phenotyping Consortium Status Apob
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000035465 VEGA Gene Model | MGI Sequence Detail 39188 C57BL/6J ±  kb
transcript OTTMUST00000090769 VEGA | MGI Sequence Detail 13934 Not Applicable 
polypeptide OTTMUSP00000049845 VEGA | MGI Sequence Detail 4505 Not Applicable 

For the selected sequences
All sequences(56) RefSeq(4) UniProt(4)
Polymorphisms
RFLP(6) : SNPs within 2kb(295 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR022176 Apolipoprotein B100 C-terminal
InterPro IPR009454 Lipid transport, open beta-sheet
InterPro IPR015819 Lipid transport protein, beta-sheet shell
InterPro IPR001747 Lipid transport protein, N-terminal
InterPro IPR015816 Vitellinogen, beta-sheet N-terminal
InterPro IPR015255 Vitellinogen, open beta-sheet
InterPro IPR015817 Vitellinogen, open beta-sheet, subdomain 1
InterPro IPR015818 Vitellinogen, open beta-sheet, subdomain 2
InterPro IPR011030 Vitellinogen, superhelical
Protein Ontology PR:000004145 apolipoprotein B-100
References
(Earliest) J:24996 Mahley RW, et al., Plasma lipoproteins: apolipoprotein structure and function. J Lipid Res. 1984 Dec 1;25(12):1277-94
(Latest) J:217130 Fossat N, et al., C to U RNA editing mediated by APOBEC1 requires RNA-binding protein RBM47. EMBO Rep. 2014 Aug;15(8):903-10
All references(160)
Disease annotation references (7)
Other
accession IDs
MGD-MRK-1370, MGI:2144785

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory