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Apob Gene Detail
Summary
  • Symbol
    Apob
  • Name
    apolipoprotein B
  • Synonyms
    apob-100, apob-48
  • Feature Type
    protein coding gene
  • IDs
    MGI:88052
    NCBI Gene: 238055
  • Gene Overview
    MyGene.info: APOB
  • Alliance
  • Transcription Start Sites
    33 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:7977648-8016835 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 12, 3.53 cM
  • Mapping Data
    26 experiments
Strain
Comparison
more
  • SNPs within 2kb
    295 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88052
protein coding gene Chr12:7977634-8016839 (.)
129S1/SvImJ MGP_129S1SvImJ_G0019581
protein coding gene Chr12:5002013-5042205 (+)
A/J MGP_AJ_G0019548
protein coding gene Chr12:4878622-4919190 (+)
AKR/J MGP_AKRJ_G0019518
protein coding gene Chr12:5186442-5228820 (+)
BALB/cJ MGP_BALBcJ_G0019523
protein coding gene Chr12:4947638-4989154 (+)
C3H/HeJ MGP_C3HHeJ_G0019329
protein coding gene Chr12:4970925-5011938 (+)
C57BL/6NJ MGP_C57BL6NJ_G0019972
protein coding gene Chr12:5134054-5174467 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017597
protein coding gene Chr12:4684974-4723162 (+)
CAST/EiJ MGP_CASTEiJ_G0018884
protein coding gene Chr12:5020593-5061611 (+)
CBA/J MGP_CBAJ_G0019300
protein coding gene Chr12:5645224-5689572 (+)
DBA/2J MGP_DBA2J_G0019413
protein coding gene Chr12:4820514-4861116 (+)
FVB/NJ MGP_FVBNJ_G0019404
protein coding gene Chr12:4798175-4837141 (+)
LP/J MGP_LPJ_G0019484
protein coding gene Chr12:5050149-5089700 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019437
protein coding gene Chr12:5467405-5512091 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0020011
protein coding gene Chr12:4953792-4995245 (+)
PWK/PhJ MGP_PWKPhJ_G0018650
protein coding gene Chr12:4875410-4957198 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018441
protein coding gene Chr12:4960096-5039203 (+)
WSB/EiJ MGP_WSBEiJ_G0018935
protein coding gene Chr12:4998071-5043620 (+)



Homology
more
  • Human Ortholog
    APOB, apolipoprotein B
  • Vertebrate Orthologs
    9
  • Human Ortholog
    APOB, apolipoprotein B
    Orthology source: HGNC, HomoloGene
  • Synonyms
    apoB-100, apoB-48, FLDB, LDLCQ4
  • Links
    NCBI Gene ID: 338
    neXtProt AC: NX_P04114
    UniProt: P04114

  • Chr Location
    2p24.1; chr2:21001429-21044073 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 328
    1 human;1 mouse;1 rat;1 chimpanzee;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: APOB
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with Apob mouse models; 1 with human APOB associations

Human Disease Mouse Models
      
IDs
View 2 models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    4 with disease annotations
  • References
    6 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    29 phenotypes from 11 alleles in 8 genetic backgrounds
    45 phenotypes from multigenic genotypes
    3 images
    118 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mutants usually die by midgestation and longer survivors exhibit exencephaly. Heterozygotes show reduced plasma cholesterol and apolipoprotein levels. Single isoform B100 and B48 null mutants are viable.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000020609 Ensembl Gene Model | MGI Sequence Detail 39188 C57BL/6J ±  kb
    transcript ENSMUST00000037811 Ensembl | MGI Sequence Detail 13934 Not Applicable  
    polypeptide ENSMUSP00000036044 Ensembl | MGI Sequence Detail 4505 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 70
      Genomic 4
      cDNA 60
      Primer pair 6

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-1370, MGI:2144785
    References
    more
    • Summaries
      All 228
      Developmental Gene Expression 18
      Diseases 6
      Gene Ontology 24
      Phenotypes 118
    • Earliest
      J:24996 Mahley RW, et al., Plasma lipoproteins: apolipoprotein structure and function. J Lipid Res. 1984 Dec 1;25(12):1277-94
    • Latest
      J:261395 Groppa E, et al., EphrinB2/EphB4 signaling regulates non-sprouting angiogenesis by VEGF. EMBO Rep. 2018 May;19(5)

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/27/2018
    MGI 6.13
    The Jackson Laboratory