Apob
Gene Detail

Symbol Name ID

Apob apolipoprotein B MGI:88052

Synonyms

apob-100, apob-48

Feature Type

protein coding gene

Genetic Map

Chromosome 12

3.53 cM
Detailed Genetic Map ± 1 cM


Mapping data(27)

Sequence Map

Chr12:7977648-8016835 bp, + strand From VEGA annotation of GRCm38   39188 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:328  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Apob

Human homologs

Human Homolog		APOB, apolipoprotein B (including Ag(x) antigen)
NCBI Gene ID		338
neXtProt AC		NX_P04114
Human Synonyms		FLDB, LDLCQ4
Human Chr (Location)		2p24-p23; chr2:21224301-21266945 (-)  GRCh37.p10
Disease Associations		(2) Diseases Associated with Human APOB

Alleles and phenotypes

All alleles(13) : Targeted(13)
 

Homozygous null mutants usually die by midgestation and longer survivors exhibit exencephaly. Heterozygotes show reduced plasma cholesterol and apolipoprotein levels. Single isoform B100 and B48 null mutants are viable.

 
Human Diseases Modeled Using Mouse Apob (2)    Alleles Annotated to Human Diseases(7)    Phenotype Images(3)

Gene Ontology (GO) classifications

All GO classifications: (74 annotations)

Process	artery morphogenesis, cholesterol efflux, ...
Component	chylomicron, cytoplasm, ...
Function	cholesterol transporter activity, enzyme binding, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (15 records)
Data Summary: Results (69)    Tissues (16)    Images (26)
Theiler Stages: 11, 17, 21, 23, 26, 28

Assay Type	Results
RNA in situ	43
Western blot	5
RT-PCR	8
RNase protection	13

cDNA source data(53)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(65) Genomic(4) cDNA(59) Primer pair(2)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000035465 (Evidence)
Ensembl Gene Model	ENSMUSG00000020609 (Evidence)
Entrez Gene	238055 (Evidence)
UniGene	221239
DFCI	TC1597783, TC1599362, TC1605478, TC1612818, TC1649586, TC1658823
DoTS	DT.492380, DT.91320976, DT.91325257, DT.94345476
NIA Mouse Gene Index	U013736
Consensus CDS Project	CCDS49022.1
International Mouse Knockout Project Status	Apob

Sequences

Length	Strain/Species
genomic	OTTMUSG00000035465	VEGA Gene Model | MGI Sequence Detail	39188	C57BL/6J
transcript	OTTMUST00000090769	VEGA | MGI Sequence Detail	13934	Not Applicable
polypeptide	OTTMUSP00000049845	VEGA | MGI Sequence Detail	4505	Not Applicable

All sequences(54) RefSeq(2) UniProt(4)

Polymorphisms

RFLP(6) : SNPs(31 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR022176	Apolipoprotein B100 C-terminal
InterPro	IPR009454	Lipid transport, open beta-sheet
InterPro	IPR015819	Lipid transport protein, beta-sheet shell
InterPro	IPR001747	Lipid transport protein, N-terminal
InterPro	IPR015816	Vitellinogen, beta-sheet N-terminal
InterPro	IPR015255	Vitellinogen, open beta-sheet
InterPro	IPR015817	Vitellinogen, open beta-sheet, subdomain 1
InterPro	IPR015818	Vitellinogen, open beta-sheet, subdomain 2
InterPro	IPR011030	Vitellinogen, superhelical
Protein Ontology	PR:000004145	apolipoprotein B-100

References

(Earliest) J:24996 Mahley RW, et al., Plasma lipoproteins: apolipoprotein structure and function. J Lipid Res. 1984 Dec 1;25(12):1277-94
(Latest) J:193795 Robbins CS, et al., Extramedullary hematopoiesis generates Ly-6C(high) monocytes that infiltrate atherosclerotic lesions. Circulation. 2012 Jan 17;125(2):364-74
All references(150)

Other accession IDs

MGD-MRK-1370, MGI:2144785