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Apex1
Gene Detail
Symbol

Name
ID
Apex1
apurinic/apyrimidinic endonuclease 1
MGI:88042
Synonyms
HAP1, Ref-1
Feature Type
protein coding gene
Genetic Map
Chromosome 14
26.30 cM, cytoband C3
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr14:50924968-50927139 bp, + strand
From VEGA annotation of GRCm38

  2172 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1241  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Apex1

Human
homologs
Human Homolog APEX1, APEX nuclease (multifunctional DNA repair enzyme) 1
NCBI Gene ID 328
neXtProt AC  NX_P27695
Human Synonyms  APE, APE1, APEN, APEX, APX, HAP1, REF1
Human Chr (Location)  14q11.2; chr14:20455131-20457772 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Gene trapped(3) Targeted(7)
Incidental mutations (data from APF )
 
Mice homozygous for a knock-out allele exhibit embryonic lethality prior to E10 associated with abnormal embryogenesis.
 
Interactions
Apex1 interacts with 18 markers (Mir33, Mir149, Mir377, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (63 annotations)
Process aging, base-excision repair, ...
Component centrosome, cytoplasm, ...
Function 3'-5' exonuclease activity, chromatin DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (10 records)
Data Summary: Results (322)    Tissues (47)    Images (24)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 313
RT-PCR 9
cDNA source data(4)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(11) Genomic(4) cDNA(4) Primer pair(3)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000019767 (Evidence)
Ensembl Gene ModelENSMUSG00000035960 (Evidence)
Entrez Gene11792 (Evidence)
DFCITC1572292
NIA Mouse Gene IndexU015575
EC3.1.-.-, 4.2.99.18
Consensus CDS ProjectCCDS27027.1
International Mouse Knockout Project StatusApex1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000019767 VEGA Gene Model | MGI Sequence Detail 2172 C57BL/6J ±  kb
transcript OTTMUST00000047275 VEGA | MGI Sequence Detail 1239 Not Applicable 
polypeptide OTTMUSP00000021336 VEGA | MGI Sequence Detail 317 Not Applicable 

For the selected sequences
All sequences(43) RefSeq(4) UniProt(9)
Polymorphisms
SNPs within 2kb(36 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR020847 AP endonuclease, family 1, binding site
InterPro IPR020848 AP endonuclease, family 1, conserved site
InterPro IPR005135 Endonuclease/exonuclease/phosphatase
InterPro IPR004808 Exodeoxyribonuclease III xth
Protein Ontology PR:000004127 DNA-(apurinic or apyrimidinic site) lyase
References
(Earliest) J:11535 Seki S, et al., cDNA and deduced amino acid sequence of a mouse DNA repair enzyme (APEX nuclease) with significant homology to Escherichia coli exonuclease III. J Biol Chem. 1991 Nov 5;266(31):20797-802
(Latest) J:212924 Katyal S, et al., Aberrant topoisomerase-1 DNA lesions are pathogenic in neurodegenerative genome instability syndromes. Nat Neurosci. 2014 Jun;17(6):813-21
All references(78)
Other
accession IDs
MGD-MRK-1352

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/16/2014
MGI 5.20
The Jackson Laboratory