Apex1
Gene Detail

Symbol Name ID

Apex1 apurinic/apyrimidinic endonuclease 1 MGI:88042

Synonyms

HAP1, Ref-1

Feature Type

protein coding gene

Genetic Map

Chromosome 14

26.30 cM, cytoband C3
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr14:50924968-50927139 bp, + strand From VEGA annotation of GRCm38   2172 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:1241  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Apex1

Human homologs

Human Homolog		APEX1, APEX nuclease (multifunctional DNA repair enzyme) 1
NCBI Gene ID		328
neXtProt AC		NX_P27695
Human Synonyms		APE, APE1, APEN, APEX, APX, HAP1, REF1
Human Chr (Location)		14q11.2; chr14:20923290-20925931 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(9) : Targeted(6) Gene trapped(3)
 

Mice homozygous for a knock-out allele exhibit embryonic lethality prior to E10 associated with abnormal embryogenesis.

 

Gene Ontology (GO) classifications

All GO classifications: (50 annotations)

Process	aging, cell redox homeostasis, ...
Component	centrosome, cytoplasm, ...
Function	3'-5' exonuclease activity, chromatin DNA binding, ...

External Resources: FuncBase

Expression

Literature Summary: (8 records)
Data Summary: Results (326)    Tissues (51)    Images (24)
Theiler Stages: 1, 2, 3, 4, 13, 21, 23, 28

Assay Type	Results
RNA in situ	313
RT-PCR	13

cDNA source data(165)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(172) Genomic(4) cDNA(165) Primer pair(3)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000019767 (Evidence)
Ensembl Gene Model	ENSMUSG00000035960 (Evidence)
Entrez Gene	11792 (Evidence)
UniGene	203
DFCI	TC1572292
NIA Mouse Gene Index	U015575
EC	3.1.-.-, 4.2.99.18
Consensus CDS Project	CCDS27027.1
International Mouse Knockout Project Status	Apex1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000019767	VEGA Gene Model | MGI Sequence Detail	2172	C57BL/6J
transcript	OTTMUST00000047275	VEGA | MGI Sequence Detail	1239	Not Applicable
polypeptide	OTTMUSP00000021336	VEGA | MGI Sequence Detail	317	Not Applicable

All sequences(37) RefSeq(2) UniProt(5)

Polymorphisms

SNPs(30 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR020847	AP endonuclease, family 1, binding site
InterPro	IPR020848	AP endonuclease, family 1, conserved site
InterPro	IPR005135	Endonuclease/exonuclease/phosphatase
InterPro	IPR004808	Exodeoxyribonuclease III xth
Protein Ontology	PR:000004127	DNA-(apurinic or apyrimidinic site) lyase

References

(Earliest) J:11535 Seki S, et al., cDNA and deduced amino acid sequence of a mouse DNA repair enzyme (APEX nuclease) with significant homology to Escherichia coli exonuclease III. J Biol Chem. 1991 Nov 5;266(31):20797-802
(Latest) J:189582 Singh S, et al., Nuclear depletion of apurinic/apyrimidinic endonuclease 1 (Ape1/Ref-1) is an indicator of energy disruption in neurons. Free Radic Biol Med. 2012 Nov 1;53(9):1782-90
All references(69)

Other accession IDs

MGD-MRK-1352