Automated description from the Alliance of Genome Resources (Release 7.0.0)
Predicted to enable several functions, including DNA binding activity; NF-kappaB binding activity; and nuclease activity. Acts upstream of or within cell redox homeostasis. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; autopod; early conceptus; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in artery disease (multiple); breast cancer; female reproductive organ cancer (multiple); spina bifida; and urinary bladder cancer. Orthologous to human APEX1 (apurinic/apyrimidinic endodeoxyribonuclease 1).