Apex1 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Apex1
apurinic/apyrimidinic endonuclease 1
MGI:88042

33 phenotypes from 4 alleles in 4 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Apex1^tm1Cur/Apex1⁺ involves: 129S1/Sv	abnormal nitric oxide homeostasis	J:102294
	abnormal response/metabolism to endogenous compounds	J:102294
	abnormal vascular smooth muscle physiology	J:119957
	abnormal vascular wound healing	J:119957
	decreased vasoconstriction	J:102294
	decreased vasodilation	J:102294
	increased circulating interleukin-1 alpha level	J:119957
	increased circulating interleukin-10 level	J:119957
	increased mean systemic arterial blood pressure	J:102294
	increased vasoconstriction	J:102294
Apex1^tm1Cur/Apex1^tm1Cur involves: 129S1/Sv * C57BL/6J	abnormal embryo development	J:34891
Apex1^tm1Cur/Apex1^tm1Cur involves: 129S1/Sv * C57BL/6J	embryonic lethality between implantation and somite formation, complete penetrance	J:34891
Apex1^tm1Djc/Apex1⁺ involves: 129X1/SvJ * NTac:NIHS	abnormal liver morphology	J:92957
Apex1^tm1Djc/Apex1⁺ involves: 129X1/SvJ * NTac:NIHS	abnormal seminiferous tubule morphology	J:92957
Apex1^tm1Djc/Apex1^tm1Djc involves: 129X1/SvJ * NTac:NIHS	abnormal embryo development	J:50702
	abnormal embryonic epiblast morphology	J:50702
	abnormal visceral yolk sac morphology	J:50702
	embryonic growth retardation	J:50702
	embryonic lethality during organogenesis, complete penetrance	J:50702
	increased cellular sensitivity to gamma-irradiation	J:50702
	increased embryonic epiblast cell apoptosis	J:50702
Apex1^tm1Ecf/Apex1⁺ either: (involves: 129/Sv) or (involves: 129/Sv * C57BL/6)	abnormal cell death	J:70397
	cardiac fibrosis	J:70397
	decreased cellular sensitivity to ultraviolet irradiation	J:70397
	heart inflammation	J:70397
	increased carcinoma incidence	J:70397
	increased cellular sensitivity to oxidative stress	J:70397
	increased lymphoma incidence	J:70397
	increased sarcoma incidence	J:70397
	increased tumor incidence	J:70397
	myocarditis	J:70397
	pericarditis	J:70397
	prenatal lethality, incomplete penetrance	J:70397
Apex1^tm1Ecf/Apex1^tm1Ecf either: (involves: 129/Sv) or (involves: 129/Sv * C57BL/6)	embryonic lethality between implantation and somite formation, complete penetrance	J:70397
Apex1^tm2Cur/Apex1^tm2Cur involves: 129S1/Sv	no abnormal phenotype detected	J:83750

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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