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Lin28b Gene Detail
Summary
  • Symbol
    Lin28b
  • Name
    lin-28 homolog B
  • Synonyms
    2810403D23Rik, D030047M17Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:3584032
    NCBI Gene: 380669
  • Alliance
    genome feature page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:45252713-45362410 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 23.50 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2373 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3584032
 protein coding gene Chr10:45252713-45362491 (-)
129S1/SvImJ ENSMUSG00200006830
 protein coding gene Chr10:42151037-42244602 (-)
A/J ENSMUSG00195002853
 protein coding gene Chr10:42420907-42514494 (-)
AKR/J ENSMUSG00220005588
 protein coding gene Chr10:42106763-42200336 (-)
BALB/cJ ENSMUSG00180011485
 protein coding gene Chr10:42510077-42603661 (-)
C3H/HeJ ENSMUSG00175009924
 protein coding gene Chr10:42302779-42396353 (-)
C57BL/6NJ ENSMUSG00215002136
 protein coding gene Chr10:42047601-42141179 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015299
 protein coding gene Chr10:40912969-41001650 (-)
CAST/EiJ ENSTCUG00005008408
 protein coding gene Chr10:42490041-42580586 (-)
CBA/J ENSMUSG00210008127
 protein coding gene Chr10:42193124-42286701 (-)
DBA/2J ENSMUSG00185003086
 protein coding gene Chr10:42344715-42438299 (-)
FVB/NJ ENSMUSG00205004849
 protein coding gene Chr10:42265090-42358677 (-)
JF1/MsJ ENSUMUG00000018804
 protein coding gene Chr10:42195051-42289166 (-)
LP/J ENSMUSG00230005331
 protein coding gene Chr10:44148983-44242561 (-)
NOD/ShiLtJ ENSMUSG00190005485
 protein coding gene Chr10:42472883-42566465 (-)
NZO/HlLtJ ENSMUSG00225016923
 protein coding gene Chr10:48434472-48528050 (-)
PWK/PhJ ENSLUMG00010004226
 protein coding gene Chr10:42291456-42385415 (-)
SPRET/EiJ ENSMSPG00010012423
 protein coding gene Chr10:43317892-43408991 (-)
WSB/EiJ ENSIUOG00005014436
 protein coding gene Chr10:42028097-42121699 (-)



Homology
more
  • Human Ortholog
    LIN28B, lin-28 RNA binding posttranscriptional regulator B
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    LIN28B, lin-28 RNA binding posttranscriptional regulator B
  • Synonyms
    CSDD2
  • Links
    NCBI Gene ID: 389421
    UniProt: Q6ZN17

  • Chr Location
    6q16.3-q21; chr6:104936616-105083332 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Lin28b mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    47 phenotypes from 9 alleles in 8 genetic backgrounds
    12 phenotypes from multigenic genotypes
    48 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit postnatal dwarfism in male, but not female, mice.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    40
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    725
  • Tissues
    80
  • cDNA Data
    57
  • Literature Summary
    24
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 380669 NCBI Gene Model | MGI Sequence Detail 109698 C57BL/6J ±  kb
    transcript NM_001031772 RefSeq | MGI Sequence Detail 5420 C57BL/6  
    polypeptide Q45KJ6 UniProt | EBI | MGI Sequence Detail 247 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 66
      cDNA 59
      Primer pair 6
      Other 1
      Antibodies 2

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGI:1917215, MGI:3026944
    References
    more
    • Summaries
      All 122
      Developmental Gene Expression 24
      Diseases 1
      Gene Ontology 7
      Phenotypes 48
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:377473 Harris B, et al., Ribosomal protein control of hematopoietic stem cell transformation through regulation of metabolism. Cell Rep. 2025 Dec 23;44(12):116688
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory