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Lin28b Gene Detail
Summary
  • Symbol
    Lin28b
  • Name
    lin-28 homolog B (C. elegans)
  • Synonyms
    2810403D23Rik, D030047M17Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:3584032
    NCBI Gene: 380669
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:45376620-45486395 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 23.50 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    468 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3584032
protein coding gene Chr10:45376617-45487304 (-)
129S1/SvImJ MGP_129S1SvImJ_G0017209
protein coding gene Chr10:44280451-44379138 (-)
A/J MGP_AJ_G0017185
protein coding gene Chr10:43025217-43120539 (-)
AKR/J MGP_AKRJ_G0017144
protein coding gene Chr10:43714961-43813727 (-)
BALB/cJ MGP_BALBcJ_G0017146
protein coding gene Chr10:43081411-43181616 (-)
C3H/HeJ MGP_C3HHeJ_G0016970
protein coding gene Chr10:44022321-44118713 (-)
C57BL/6NJ MGP_C57BL6NJ_G0017604
protein coding gene Chr10:45627972-45733558 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015299
protein coding gene Chr10:40912969-41001650 (-)
CAST/EiJ MGP_CASTEiJ_G0016544
protein coding gene Chr10:44294134-44387707 (-)
CBA/J MGP_CBAJ_G0016941
protein coding gene Chr10:47661882-47769145 (-)
DBA/2J MGP_DBA2J_G0017046
protein coding gene Chr10:42437694-42532096 (-)
FVB/NJ MGP_FVBNJ_G0017040
protein coding gene Chr10:41940609-42036685 (-)
LP/J MGP_LPJ_G0017121
protein coding gene Chr10:44305532-44403881 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0017069
protein coding gene Chr10:48316117-48441595 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0017640
protein coding gene Chr10:43711840-43809630 (-)
PWK/PhJ MGP_PWKPhJ_G0016323
protein coding gene Chr10:42418653-42516995 (-)
SPRET/EiJ MGP_SPRETEiJ_G0016108
protein coding gene Chr10:43515880-43610991 (-)
WSB/EiJ MGP_WSBEiJ_G0016607
protein coding gene Chr10:43953055-44048739 (-)



Homology
more
  • Human Ortholog
    LIN28B, lin-28 homolog B
  • Vertebrate Orthologs
    9
  • Human Ortholog
    LIN28B, lin-28 homolog B
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CSDD2
  • Links
    NCBI Gene ID: 389421
    neXtProt AC: NX_Q6ZN17
    UniProt: Q6ZN17

  • Chr Location
    6q16.3-q21; chr6:104936999-105083332 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Lin28b mouse models

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    48 phenotypes from 9 alleles in 8 genetic backgrounds
    25 phenotypes from multigenic genotypes
    27 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit postnatal dwarfism in male, but not female, mice.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000063804 Ensembl Gene Model | MGI Sequence Detail 109776 C57BL/6J ±  kb
    transcript ENSMUST00000079390 Ensembl | MGI Sequence Detail 5402 Not Applicable  
    polypeptide ENSMUSP00000078361 Ensembl | MGI Sequence Detail 271 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 59
      cDNA 57
      Primer pair 2

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGI:1917215, MGI:3026944
    References
    more
    • Summaries
      All 68
      Developmental Gene Expression 11
      Diseases 2
      Gene Ontology 3
      Phenotypes 27
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:264256 Bernardo AS, et al., Mammalian embryo comparison identifies novel pluripotency genes associated with the naive or primed state. Biol Open. 2018 Aug 17;7(8)

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/13/2018
    MGI 6.13
    The Jackson Laboratory