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Duox2
Gene Detail
 Symbol
Name
ID
Duox2
dual oxidase 2
MGI:3036280
Synonyms A430065P05Rik
Feature Type protein coding gene
Genetic Map
Chromosome 2
60.61 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr2:122279247-122298165 bp, - strand
From VEGA annotation of GRCm38

  18919 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:9689  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Duox2

Human
homologs
Human Homolog DUOX2, dual oxidase 2
NCBI Gene ID 50506
neXtProt AC  NX_Q9NRD8
Human Synonyms  LNOX2, NOXEF2, P138-TOX, TDH6, THOX2
Human Chr (Location)  15q15.3; chr15:45092653-45114161 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human DUOX2
Alleles
and
phenotypes
All alleles(5) : Targeted(4) Spontaneous(1)
 
Mice homozygous for a spontaneous mutation fail to breed and are congenitally hypothyroid (low T4, high TSH), dwarf, and hearing impaired. Anterior pituitaries are dysplastic. Cochlear defects include delayed formation of the inner sulcus and tunnel of Corti and a thickened tectorial membrane.
 
Human Diseases Modeled Using Mouse Duox2 (1)    Alleles Annotated to Human Diseases(1)   
Gene Ontology
(GO)
classifications
All GO classifications: (18 annotations)
Process adenohypophysis morphogenesis, bone mineralization, ...
Component extracellular vesicular exosome, integral component of membrane, ...
Function calcium ion binding, NAD(P)H oxidase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (101)    Tissues (96)    Images (1)
Theiler Stages: 22, 28
Assay TypeResults
RNA in situ 94
RT-PCR 7
cDNA source data(5)
External Resources: GEO   ArrayExpress
Molecular
reagents
All nucleic(9) cDNA(5) Primer pair(3) Other(1)
Microarray probesets(1)
Other database
links
VEGA Gene ModelOTTMUSG00000015565 (Evidence)
Ensembl Gene ModelENSMUSG00000068452 (Evidence)
Entrez Gene214593 (Evidence)
UniGene358846
DFCITC1594427
DoTSDT.91390622, DT.91582293
NIA Mouse Gene IndexU023274
Consensus CDS ProjectCCDS38221.1
International Mouse Knockout Project StatusDuox2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000015565 VEGA Gene Model | MGI Sequence Detail 18919 C57BL/6J ±  kb
transcript OTTMUST00000036986 VEGA | MGI Sequence Detail 5744 Not Applicable 
polypeptide OTTMUSP00000016595 VEGA | MGI Sequence Detail 1517 Not Applicable 

For the selected sequences
All sequences(25) RefSeq(4) UniProt(3)
Polymorphisms SNPs within 2kb(207 from dbSNP Build 137)    SNPs within 2kb including multiple locations(225)
Protein-related
information
ResourceIDDescription
InterPro IPR018247 EF-Hand 1, calcium-binding site
InterPro IPR002048 EF-hand domain
InterPro IPR011992 EF-hand-like domain
InterPro IPR013112 FAD-binding 8
InterPro IPR017927 Ferredoxin reductase-type FAD-binding domain
InterPro IPR013121 Ferric reductase, NAD binding
InterPro IPR013130 Ferric reductase transmembrane component-like domain
InterPro IPR010255 Haem peroxidase
InterPro IPR002007 Haem peroxidase, animal
InterPro IPR019791 Haem peroxidase, animal, subgroup
InterPro IPR017938 Riboflavin synthase-like beta-barrel
Protein Ontology PR:000006728 dual oxidase 2
References (Earliest) J:83395 Sandell LL, et al., Gatm, a creatine synthesis enzyme, is imprinted in mouse placenta. Proc Natl Acad Sci U S A. 2003 Apr 15;100(8):4622-7
(Latest) J:176192 Hayashi S, et al., Lack of In Vivo Functional Compensation Between Pax Family Groups II and III in Rodents. Mol Biol Evol. 2011 Oct;28(10):2787-98
All references(29)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory