Duox2
Gene Detail

Symbol Name ID

Duox2 dual oxidase 2 MGI:3036280

Synonyms

A430065P05Rik

Feature Type

protein coding gene

Genetic Map

Chromosome 2

60.61 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr2:122279247-122298165 bp, - strand From VEGA annotation of GRCm38   18919 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:9689  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Duox2

Human homologs

Human Homolog		DUOX2, dual oxidase 2
NCBI Gene ID		50506
neXtProt AC		NX_Q9NRD8
Human Synonyms		LNOX2, NOXEF2, P138-TOX, TDH6, THOX2
Human Chr (Location)		15q15.3; chr15:45384852-45406359 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human DUOX2

Alleles and phenotypes

All alleles(5) : Targeted(4) Spontaneous(1)
 

Mice homozygous for a spontaneous mutation fail to breed and are congenitally hypothyroid (low T4, high TSH), dwarf, and hearing impaired. Anterior pituitaries are dysplastic. Cochlear defects include delayed formation of the inner sulcus and tunnel of Corti and a thickened tectorial membrane.

 
Human Diseases Modeled Using Mouse Duox2 (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (16 annotations)

Process	adenohypophysis morphogenesis, bone mineralization, ...
Component	integral to membrane, membrane
Function	calcium ion binding, NAD(P)H oxidase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (5 records)
Data Summary: Results (101)    Tissues (96)    Images (1)
Theiler Stages: 22, 28

Assay Type	Results
RNA in situ	94
RT-PCR	7

cDNA source data(6)
External Resources: GEO   ArrayExpress

Molecular reagents

All nucleic(10) cDNA(6) Primer pair(3) Other(1)
Microarray probesets(1)

Other database links

VEGA Gene Model	OTTMUSG00000015565 (Evidence)
Ensembl Gene Model	ENSMUSG00000068452 (Evidence)
Entrez Gene	214593 (Evidence)
UniGene	358846
DFCI	TC1594427
DoTS	DT.91582293
NIA Mouse Gene Index	U023274
Consensus CDS Project	CCDS38221.1
International Mouse Knockout Project Status	Duox2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000015565	VEGA Gene Model | MGI Sequence Detail	18919	C57BL/6J
transcript	OTTMUST00000036986	VEGA | MGI Sequence Detail	5744	Not Applicable
polypeptide	OTTMUSP00000016595	VEGA | MGI Sequence Detail	1517	Not Applicable

All sequences(21) RefSeq(2) UniProt(3)

Polymorphisms

SNPs(112 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR002048	Calcium-binding EF-hand
InterPro	IPR018247	EF-Hand 1, calcium-binding site
InterPro	IPR018249	EF-HAND 2
InterPro	IPR011992	EF-hand-like domain
InterPro	IPR013112	FAD-binding 8
InterPro	IPR017927	Ferredoxin reductase-type FAD-binding domain
InterPro	IPR013121	Ferric reductase, NAD binding
InterPro	IPR013130	Ferric reductase transmembrane component-like domain
InterPro	IPR010255	Haem peroxidase
InterPro	IPR002007	Haem peroxidase, animal
InterPro	IPR019791	Haem peroxidase, animal, subgroup
InterPro	IPR017938	Riboflavin synthase-like beta-barrel
Protein Ontology	PR:000006728	dual oxidase 2

References

(Earliest) J:83395 Sandell LL, et al., Gatm, a creatine synthesis enzyme, is imprinted in mouse placenta. Proc Natl Acad Sci U S A. 2003 Apr 15;100(8):4622-7
(Latest) J:176192 Hayashi S, et al., Lack of In Vivo Functional Compensation Between Pax Family Groups II and III in Rodents. Mol Biol Evol. 2011 Oct;28(10):2787-98
All references(29)