Kmt2d
Gene Detail

Symbol Name ID

Kmt2d lysine (K)-specific methyltransferase 2D MGI:2682319

Synonyms

C430014K11Rik, Mll2, Mll4

Feature Type

protein coding gene

Genetic Map

Chromosome 15

54.80 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr15:98831669-98871183 bp, - strand From Ensembl annotation of GRCm38   39515 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:86893  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Gene Tree: Kmt2d

Human homologs

Human Homolog		KMT2D, lysine (K)-specific methyltransferase 2D
NCBI Gene ID		8085
neXtProt AC		NX_O14686
Human Synonyms		AAD10, ALR, CAGL114, KABUK1, KMS, MLL2, MLL4, TNRC21
Human Chr (Location)		12q13.12; chr12:49412758-49449107 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human KMT2D

Alleles and phenotypes

All alleles(23) : Targeted(3) Gene trapped(20)

Gene Ontology (GO) classifications

All GO classifications: (22 annotations)

Process	chromatin modification, chromatin silencing, ...
Component	histone methyltransferase complex, nucleus
Function	histone-lysine N-methyltransferase activity, metal ion binding, ...

External Resources: FuncBase

Expression

Literature Summary: (2 records)
Data Summary: Results (96)    Tissues (95)    Images (9)
Theiler Stages: 21, 22

Assay Type	Results
RNA in situ	94
RT-PCR	2

cDNA source data(37)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(39) cDNA(37) Primer pair(2)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000048154 (Evidence)
Entrez Gene	381022 (Evidence)
UniGene	264889
DFCI	TC1582889, TC1590337, TC1604638
EC	2.1.1.43
Consensus CDS Project	CCDS49725.2
International Mouse Knockout Project Status	Kmt2d

Sequences

Length	Strain/Species
genomic	ENSMUSG00000048154	Ensembl Gene Model | MGI Sequence Detail	39515	C57BL/6J
transcript	ENSMUST00000178486	Ensembl | MGI Sequence Detail	19805	Not Applicable
polypeptide	ENSMUSP00000135941	Ensembl | MGI Sequence Detail	5588	Not Applicable

All sequences(25) RefSeq(3) UniProt(4)

Polymorphisms

SNPs(110 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR003889	FY-rich, C-terminal
InterPro	IPR003888	FY-rich, N-terminal
InterPro	IPR009071	High mobility group (HMG) box domain
InterPro	IPR003616	Post-SET domain
InterPro	IPR001214	SET domain
InterPro	IPR011011	Zinc finger, FYVE/PHD-type
InterPro	IPR019787	Zinc finger, PHD-finger
InterPro	IPR001965	Zinc finger, PHD-type
InterPro	IPR013083	Zinc finger, RING/FYVE/PHD-type
InterPro	IPR001841	Zinc finger, RING-type
Protein Ontology	PR:000010446	histone-lysine N-methyltransferase MLL2

References

(Earliest) J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
(Latest) J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
All references(43)

Other accession IDs

MGI:2443148, MGI:2448505