Phenotypes Associated with This Genotype

Genotype
MGI:6515623

• Allelic Composition: Kmt2d^{Gt(RRT024)Byg}/Kmt2d⁺
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

decreased body fat mass ( J:301497 )

• mice exhibit low levels of body fat mass

decreased susceptibility to diet-induced obesity ( J:301497 )

• mice exhibit resistance to high-fat diet-induced obesity

decreased body size ( J:301083 )

• dwarfism

decreased body weight ( J:301083 , J:301497 )

• mice are lighter after 11 weeks of age (J:301497)

decreased body length ( J:301083 )

• reduction in linear length

nervous system

decreased neuron number ( J:301083 )

• marker analysis shows a reduction in growth hormone-releasing hormone (GHRH) producing neurons

• however, proopiemlanocortin (POMC)-neuron numbers are normal and agouti-related peptide (agRP)-neurons are mildly increased

adipose tissue

decreased body fat mass ( J:301497 )

• mice exhibit low levels of body fat mass

homeostasis/metabolism

decreased susceptibility to diet-induced obesity ( J:301497 )

• mice exhibit resistance to high-fat diet-induced obesity

improved glucose tolerance ( J:301497 )

increased insulin sensitivity ( J:301497 )

increased bile salt level ( J:301497 )

• mice exhibit increased serum and feces bile acid levels

• both serum and hepatic bile acid levels are increased during daytime, resulting in a loss of rhythmic fluctuation of bile acid levels over the circadian cycle

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Kabuki syndrome		DOID:0060473	OMIM:147920 OMIM:300867	J:301083