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Crb2 Gene Detail
Summary
  • Symbol
    Crb2
  • Name
    crumbs family member 2
  • Feature Type
    protein coding gene
  • IDs
    MGI:2679260
    NCBI Gene: 241324
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:37776249-37799103 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 24.19 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    40 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2679260
protein coding gene Chr2:37776225-37799103 (+)
129S1/SvImJ MGP_129S1SvImJ_G0025699
protein coding gene Chr2:36494275-36518341 (+)
A/J MGP_AJ_G0025676
protein coding gene Chr2:35001506-35024385 (+)
AKR/J MGP_AKRJ_G0025646
protein coding gene Chr2:36158388-36181199 (+)
BALB/cJ MGP_BALBcJ_G0025671
protein coding gene Chr2:35058716-35081902 (+)
C3H/HeJ MGP_C3HHeJ_G0025432
protein coding gene Chr2:36076431-36101884 (+)
C57BL/6NJ MGP_C57BL6NJ_G0026117
protein coding gene Chr2:37529735-37554053 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0023522
protein coding gene Chr2:33665407-33688624 (+)
CAST/EiJ MGP_CASTEiJ_G0024895
protein coding gene Chr2:35996889-36025237 (+)
CBA/J MGP_CBAJ_G0025411
protein coding gene Chr2:38935013-38959968 (+)
DBA/2J MGP_DBA2J_G0025543
protein coding gene Chr2:34744019-34766972 (+)
FVB/NJ MGP_FVBNJ_G0025505
protein coding gene Chr2:34622336-34645674 (+)
LP/J MGP_LPJ_G0025630
protein coding gene Chr2:36388051-36410901 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0025536
protein coding gene Chr2:38539509-38563017 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0026175
protein coding gene Chr2:36040012-36066428 (+)
PWK/PhJ MGP_PWKPhJ_G0024637
protein coding gene Chr2:34641173-34664106 (+)
SPRET/EiJ MGP_SPRETEiJ_G0024442
protein coding gene Chr2:36161687-36185393 (+)
WSB/EiJ MGP_WSBEiJ_G0024963
protein coding gene Chr2:36224366-36247187 (+)



Homology
more
  • Human Ortholog
    CRB2, crumbs cell polarity complex component 2
  • Vertebrate Orthologs
    7
  • Human Ortholog
    CRB2, crumbs cell polarity complex component 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    FSGS9, VMCKD
  • Links
    NCBI Gene ID: 286204
    neXtProt AC: NX_Q5IJ48
    UniProt: Q5IJ48

  • Chr Location
    9q33.3; chr9:123354065-123380335 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Crb2 mouse models; 1 with human CRB2 associations

Human Disease Mouse Models
      
IDs
View 2 models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    56 phenotypes from 3 alleles in 6 genetic backgrounds
    19 phenotypes from multigenic genotypes
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous inactivation of this gene causes severe gastrulation defects, impaired somitogenesis and organogenesis. and complete embryonic death by E12.5. Several organ primordia, including neuroepithelium, gut, and heart, fail to form properly.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000035403 Ensembl Gene Model | MGI Sequence Detail 22855 C57BL/6J ±  kb
    transcript ENSMUST00000050372 Ensembl | MGI Sequence Detail 6372 Not Applicable  
    polypeptide ENSMUSP00000058007 Ensembl | MGI Sequence Detail 1282 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 31
      cDNA 30
      Primer pair 1

      Microarray probesets 1
    References
    more
    • Summaries
      All 52
      Developmental Gene Expression 16
      Diseases 3
      Gene Ontology 8
      Phenotypes 18
    • Earliest
      J:82808 Strausberg RL, et al., Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903
    • Latest
      J:266927 Quinn PM, et al., CRB2 in immature photoreceptors determines the superior-inferior symmetry of the developing retina to maintain retinal structure and function. Hum Mol Genet. 2018 Sep 15;27(18):3137-3153

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    03/13/2019
    MGI 6.13
    The Jackson Laboratory