Symbol
Name
ID

Crb2
crumbs family member 2
MGI:2679260

Phenotype annotations related to vision/eye

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Mouse Phenotypes

vision/eye phenotype

abnormal retina blood vessel morphology

retina neovascularization

abnormal Muller cell morphology

decreased retina photoreceptor cell number

abnormal retina bipolar cell morphology

short retina cone cell outer segment

short retina rod cell outer segment

abnormal retina cone cell outer segment morphology

abnormal retina cone cell morphology

abnormal retina pigment epithelium morphology

abnormal ocular fundus morphology

abnormal retina morphology

abnormal retina layer morphology

abnormal retina neuronal layer morphology

abnormal retina ganglion layer morphology

abnormal retina outer nuclear layer morphology

thin retina outer nuclear layer

abnormal retina outer plexiform layer morphology

abnormal retina photoreceptor layer morphology

abnormal retina outer limiting membrane morphology

increased susceptibility to age-related retinal degeneration

retina fold

abnormal electroretinogram waveform feature

decreased a-wave amplitude

abnormal eye electrophysiology

abnormal cone electrophysiology

abnormal rod electrophysiology

Availability

Mouse Genotype

Crb2^{tm1a(KOMP)Wtsi}/Crb2⁺

Crb2^tm1.1Wij/Crb2^tm1.1Wij
Tg(Chx10-EGFP/cre,-ALPP)2Clc/0 (conditional)

Crb2^tm1.1Wij/Crb2^tm1.1Wij
Tg(Crx-cre)1Tfur/0 (conditional)

Crb2^tm1.1Wij/Crb2^tm1.1Wij
Tg(Pdgfra-cre)1Clc/0 (conditional)

Crb2^tm1.1Wij/Crb2^tm1.1Wij (conditional)

Crb2^tm1.1Wij/Crb2⁺
Tg(Chx10-EGFP/cre,-ALPP)2Clc/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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