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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
Crb2
crumbs family member 2
MGI:2679260
61 phenotypes from 3 alleles in 6 genetic backgrounds
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Allelic Composition
Genetic Background
Annotated Term Reference
Crb2tm1.1Wij/Crb2+
Tg(Chx10-EGFP/cre,-ALPP)2Clc/0
involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6 * SJL
normal vision/eye phenotype J:191149
Crb2tm1.1Wij/Crb2tm1.1Wij
involves: 129P2/OlaHsd * 129S4/SvJaeSor
no abnormal phenotype detected J:191149
Crb2tm1.1Wij/Crb2tm1.1Wij
involves: 129P2/OlaHsd * C57BL/6J
abnormal retina layer morphology J:210675
abnormal retina outer plexiform layer morphology J:210675
Crb2tm1.1Wij/Crb2tm1.1Wij
Tg(Chx10-EGFP/cre,-ALPP)2Clc/0
involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6 * SJL
abnormal cone electrophysiology J:191149
abnormal eye electrophysiology J:191149
abnormal retina bipolar cell morphology J:191149
abnormal retina blood vessel morphology J:191149
abnormal retina cone cell morphology J:191149
abnormal retina layer morphology J:191149
abnormal retina morphology J:191149
abnormal retina neuronal layer morphology J:191149
abnormal retina outer limiting membrane morphology J:191149
abnormal retina photoreceptor layer morphology J:191149
abnormal retina pigment epithelium morphology J:191149
abnormal rod electrophysiology J:191149
decreased retina photoreceptor cell number J:191149
increased susceptibility to age-related retinal degeneration J:191149
thin retina outer nuclear layer J:191149
Crb2tm1.1Wij/Crb2tm1.1Wij
Tg(Crx-cre)1Tfur/0
involves: 129P2/OlaHsd * C57BL/6J
abnormal electroretinogram waveform feature J:210675
abnormal Muller cell morphology J:210675
abnormal ocular fundus morphology J:210675
abnormal retina cone cell outer segment morphology J:210675
abnormal retina ganglion layer morphology J:210675
abnormal retina layer morphology J:210675
abnormal retina morphology J:210675
abnormal retina outer limiting membrane morphology J:210675
abnormal retina outer nuclear layer morphology J:210675
abnormal retina outer plexiform layer morphology J:210675
abnormal retina photoreceptor layer morphology J:210675
abnormal retina pigment epithelium morphology J:210675
decreased a-wave amplitude J:210675
dilated brain ventricle J:210675
hydrocephaly J:210675
increased susceptibility to age-related retinal degeneration J:210675
retina fold J:210675
retina neovascularization J:210675
short retina cone cell outer segment J:210675
short retina rod cell outer segment J:210675
thin retina outer nuclear layer J:210675
Crb2tm1.1Wij/Crb2tm1.1Wij
Tg(Pdgfra-cre)1Clc/0
involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J
abnormal retina layer morphology J:210675
abnormal retina outer limiting membrane morphology J:210675
abnormal retina outer nuclear layer morphology J:210675
prenatal lethality, incomplete penetrance J:210675
thin retina outer nuclear layer J:210675
Crb2tm1a(KOMP)Wtsi/Crb2+
C57BL/6N-Crb2tm1a(KOMP)Wtsi/Wtsi
abnormal retina morphology J:211773
abnormal vibrissa morphology J:211773
Crb2tm1a(KOMP)Wtsi/Crb2tm1a(KOMP)Wtsi
C57BL/6N-Crb2tm1a(KOMP)Wtsi/Wtsi
abnormal chorion morphology J:261316
abnormal placenta morphology J:261316
abnormal visceral yolk sac morphology J:261316
embryonic lethality during organogenesis, complete penetrance J:261316
preweaning lethality, complete penetrance J:211773
Crb2tm1Vlcg/Crb2tm1Vlcg
B6.Cg-Crb2tm1Vlcg
abnormal anterior primitive streak morphology J:177837
abnormal chorioallantoic fusion J:177837
abnormal digestive system development J:177837
abnormal embryonic epiblast morphology J:177837
abnormal embryonic neuroepithelium morphology J:177837
abnormal embryonic tissue morphology J:177837
abnormal endoderm development J:177837
abnormal foregut morphology J:177837
abnormal gastrulation J:177837
abnormal head fold morphology J:177837
abnormal mesoderm development J:177837
abnormal notochord morphology J:177837
abnormal primitive streak morphology J:177837
abnormal somite development J:177837
abnormal visceral yolk sac blood island morphology J:177837
abnormal vitelline vasculature morphology J:177837
absent heart tube J:177837
embryonic lethality during organogenesis, complete penetrance J:177837
failure of chorioallantoic fusion J:177837
failure of initiation of embryo turning J:177837
increased embryo size J:177837
open neural tube J:177837
small allantois J:177837
small amniotic cavity J:177837

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/23/2024
MGI 6.23
The Jackson Laboratory