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Grhl3
Gene Detail
Symbol

Name
ID
Grhl3
grainyhead-like 3 (Drosophila)
MGI:2655333
Synonyms
ct, Get1, nmf231, Som
Feature Type
protein coding gene
Genetic Map
Chromosome 4
67.76 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr4:135541888-135573630 bp, - strand
From VEGA annotation of GRCm38

  31743 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:18864  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Grhl3

Human
homologs
Human Homolog GRHL3, grainyhead-like 3 (Drosophila)
NCBI Gene ID 57822
neXtProt AC  NX_Q8TE85
Human Synonyms  SOM, TFCP2L4, VWS2
Human Chr (Location)  1p36.11; chr1:24319322-24364482 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human GRHL3
Mutations,
alleles, and
phenotypes
All mutations/alleles(71) : Chemically induced (ENU)(1) Gene trapped(59) Spontaneous(2) Targeted(9)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for the variably penetrant curly-tail mutation (ct) show symptoms of cranial or spinal neural tube defects such as curly tails and/or spina bifida; homozygotes with more severe phenotypes display exencephaly and die in utero. Homozygous knockout mice show severe neural tube defects.
 
Phenotype Images(1)
Interactions
Grhl3 interacts with 175 markers (Mir1b, Mir23a, Mir23b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (24 annotations)
Process central nervous system development, cochlea morphogenesis, ...
Component nucleus
Function DNA binding, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (20 records)
Data Summary: Results (297)    Tissues (202)    Images (58)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 3
RNA in situ 244
In situ reporter (knock in) 5
Northern blot 18
RT-PCR 27
cDNA source data(9)
External Resources: GEO   Expression Atlas
Molecular
reagents
All nucleic(19) cDNA(11) Primer pair(6) Other(2)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000009727 (Evidence)
Ensembl Gene ModelENSMUSG00000037188 (Evidence)
Entrez Gene230824 (Evidence)
UniGene331972
DFCITC1583463
DoTSDT.40153472
NIA Mouse Gene IndexU138529
Consensus CDS ProjectCCDS38920.1
International Mouse Knockout Project StatusGrhl3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000009727 VEGA Gene Model | MGI Sequence Detail 31743 C57BL/6J ±  kb
transcript OTTMUST00000022462 VEGA | MGI Sequence Detail 2789 Not Applicable 
polypeptide OTTMUSP00000010245 VEGA | MGI Sequence Detail 603 Not Applicable 

For the selected sequences
All sequences(20) RefSeq(6) UniProt(1)
Polymorphisms
SNPs within 2kb(241 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR007604 CP2 transcription factor
Protein Ontology PR:000008231 grainyhead-like protein 3
References
(Earliest) J:264 Gruneberg H, Genetical studies on the skeleton of the mouse. VIII. Curly-tail. J Genet. 1954;52:52-67
(Latest) J:204744 Wang X, et al., LRG1 promotes angiogenesis by modulating endothelial TGF-beta signalling. Nature. 2013 Jul 18;499(7458):306-11
All references(102)
Other
accession IDs
MGD-MRK-2211, MGI:2140331, MGI:88550

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/16/2014
MGI 5.20
The Jackson Laboratory