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Grhl3 Gene Detail
Summary
  • Symbol
    Grhl3
  • Name
    grainyhead like transcription factor 3
  • Synonyms
    ct, Get1, nmf231, Som
  • Feature Type
    protein coding gene
  • IDs
    MGI:2655333
    NCBI Gene: 230824
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr4:135541888-135573630 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      31743 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 67.76 cM
  • Mapping Data
    5 experiments
Homology
more
  • Human Ortholog
    GRHL3, grainyhead like transcription factor 3
  • Vertebrate Orthologs
    10
  • Human Ortholog
    GRHL3, grainyhead like transcription factor 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    SOM, TFCP2L4, VWS2
  • Links
    NCBI Gene ID: 57822
    neXtProt AC: NX_Q8TE85
    UniProt: Q8TE85

  • Chr Location
    1p36.11; chr1:24319322-24364482 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 18864
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: GRHL3
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with Grhl3 mouse models; 1 with human GRHL3 associations

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    64 phenotypes from 11 alleles in 19 genetic backgrounds
    33 phenotypes from multigenic genotypes
    1 images
    79 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for the variably penetrant curly-tail mutation (ct) show symptoms of cranial or spinal neural tube defects such as curly tails and/or spina bifida; homozygotes with more severe phenotypes display exencephaly and die in utero. Homozygous knockout mice show severe neural tube defects.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000009727 VEGA Gene Model | MGI Sequence Detail 31743 C57BL/6J ±  kb
    transcript OTTMUST00000022462 VEGA | MGI Sequence Detail 2789 Not Applicable  
    polypeptide OTTMUSP00000010245 VEGA | MGI Sequence Detail 603 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      241 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 20
      cDNA 11
      Primer pair 6
      Other 3

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-2211, MGI:2140331, MGI:88550
    References
    more
    • Summaries
      All 121
      Developmental Gene Expression 33
      Diseases 1
      Gene Ontology 14
      Phenotypes 79
    • Earliest
      J:264 Gruneberg H, Genetical studies on the skeleton of the mouse. VIII. Curly-tail. J Genet. 1954;52:52-67
    • Latest
      J:258769 De Castro SCP, et al., Neural tube closure depends on expression of Grainyhead-like 3 in multiple tissues. Dev Biol. 2018 Mar 15;435(2):130-137

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    Funding Information
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    last database update
    06/12/2018
    MGI 6.12
    The Jackson Laboratory