Automated description from the Alliance of Genome Resources (Release 5.4.0)
Enables DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in establishment of skin barrier; gene expression; and neural tube closure. Acts upstream of or within several processes, including embryonic morphogenesis; eyelid development in camera-type eye; and positive regulation of macromolecule metabolic process. Located in nucleus. Is expressed in several structures, including alimentary system; embryo ectoderm; genitourinary system; heart; and hindlimb. Used to study Van der Woude syndrome. Orthologous to human GRHL3 (grainyhead like transcription factor 3).