42 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Axd/Axd+ Grhl3ct/Grhl3+ involves: BALB/c * C3H/HeN * C57BL/6 * GFF	curly tail	J:170759
Gna12tm1Citb/Gna12tm1Citb Gna13tm2Cgh/Gna13tm2Cgh Grhl3tm1(cre)Cgh/Grhl3+ involves: 129P2/OlaHsd * 129S1/Sv * 129S4/SvJae * C57BL/6 * SJL	abnormal embryo development	J:157446
	abnormal embryo turning	J:157446
	embryonic lethality during organogenesis, complete penetrance	J:157446
Gna13tm2Cgh/Gna13tm2Cgh Grhl3tm1(cre)Cgh/Grhl3+ involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * SJL	normal mortality/aging	J:157446
	normal nervous system phenotype	J:157446
Gnaztm1Lfb/Gnaz+ Grhl3tm1(cre)Cgh/Grhl3+ Gt(ROSA)26Sortm1(ptxA)Cgh/Gt(ROSA)26Sor+ involves: 129P2/OlaHsd * C57BL/6 * SJL	exencephaly	J:157446
	spina bifida	J:157446
Gnaztm1Lfb/Gnaztm1Lfb Grhl3tm1(cre)Cgh/Grhl3+ Gt(ROSA)26Sortm1(ptxA)Cgh/Gt(ROSA)26Sor+ involves: 129P2/OlaHsd * C57BL/6 * SJL	exencephaly	J:157446
	spina bifida	J:157446
Grhl1tm1Jane/Grhl1tm1Jane Grhl3tm1Jane/Grhl3tm3.1Jane Tg(KRT14-cre)8Brn/0 involves: 129S1/Sv * C57BL/6 * FVB/N	abnormal corneocyte envelope morphology	J:233531
	impaired skin barrier function	J:233531
	postnatal lethality, complete penetrance	J:233531
Grhl1tm1Jane/Grhl1tm1Jane Grhl3tm1Jane/Grhl3tm3.1Jane Tg(KRT14-cre/ERT)20Efu/0 involves: 129S1/Sv * C57BL/6 * CD-1	abnormal corneocyte envelope morphology	J:233531
	impaired skin barrier function	J:233531
	postnatal lethality, complete penetrance	J:233531
	thick epidermis	J:233531
Grhl2tm1.1Jane/Grhl2+ Grhl3tm1Jane/Grhl3+ involves: 129S1/Sv * BALB/cJ * C57BL/6	abnormal neural tube morphology	J:164805
	abnormal vertebral pedicle morphology	J:164805
	curly tail	J:164805
	exencephaly	J:164805
Grhl2tm1.1Jane/Grhl2+ Grhl3tm1Jane/Grhl3tm1Jane involves: 129S1/Sv * BALB/cJ * C57BL/6	abnormal vertebral pedicle morphology	J:164805
	normal craniofacial phenotype	J:164805
	exencephaly	J:164805
	spina bifida	J:164805
Grhl2tm1.1Jane/Grhl2tm1.1Jane Grhl3tm1Jane/Grhl3+ involves: 129S1/Sv * BALB/cJ * C57BL/6	abnormal vertebral pedicle morphology	J:164805
	cranioschisis	J:164805
	facial cleft	J:164805
	spina bifida	J:164805
Grhl2tm1.1Jane/Grhl2tm1.1Jane Grhl3tm1Jane/Grhl3tm1Jane involves: 129S1/Sv * BALB/cJ * C57BL/6	cranioschisis	J:164805
	facial cleft	J:164805
	spina bifida	J:164805
Grhl3ct-J/Grhl3ct-J mct1C57BL/6J/mct1C57BL/6J involves: BALB/cByJ * STOCK ct/J	curly tail	J:29366
Grhl3ct/? Vangl2Lp/Vangl2+ involves: A * GFF	abnormal astrocyte morphology	J:125330
	abnormal motor capabilities/coordination/movement	J:125330
	abnormal spinal cord morphology	J:125330
	decreased fetal weight	J:125330
	meningomyelocele	J:125330
Grhl3tm1(cre)Cgh/Grhl3+ Gt(ROSA)26Sortm1(ptxA)Cgh/Gt(ROSA)26Sor+ involves: 129P2/OlaHsd * C57BL/6 * SJL	abnormal neural tube closure	J:157446
	exencephaly	J:157446
Grhl3tm1(cre)Cgh/Grhl3+ Gt(ROSA)26Sortm1(ptxA)Cgh/Gt(ROSA)26Sor+ Rac1tm1Djk/Rac1tm1Djk involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * SJL	exencephaly	J:157446
	spina bifida	J:157446
Grhl3tm1(cre)Cgh/Grhl3+ Usp39em1Imat/Usp39+ involves: 129P2/OlaHsd * CD-1	abnormal hair growth	J:324183
	scaly skin	J:324183
	thick skin	J:324183
Grhl3tm1(cre)Cgh/Grhl3tm1(cre)Cgh Usp39em1Imat/Usp39+ involves: 129P2/OlaHsd * CD-1	failure of eyelid fusion	J:324183
Grhl3tm1Bogi/Grhl3+ Irf6Gt(OST398253)Lex/Irf6+ involves: 129S5/SvEvBrd * C57BL/6 * C57BL/6J	abnormal craniofacial development	J:226218
	abnormal periderm development	J:226218
	postnatal lethality, incomplete penetrance	J:226218
	prenatal lethality, incomplete penetrance	J:226218
Grhl3tm1Bogi/Grhl3tm1Bogi Lmo4tm1.1Gng/Lmo4tm1.1Gng involves: 129X1/SvJ * C57BL/6J	abnormal corneocyte envelope morphology	J:114626
	abnormal epidermal layer morphology	J:114626
	abnormal epidermis stratum corneum morphology	J:114626
	curly tail	J:114626
	exencephaly	J:114626
	eyelids open at birth	J:114626
	spina bifida	J:114626
Grhl3tm1Jane/Grhl3+ Ptentm1Mak/Pten+ involves: 129P2/OlaHsd * 129S1/Sv	increased skin papilloma incidence	J:178952
	increased skin squamous cell carcinoma incidence	J:178952
Grhl3tm1Jane/Grhl3tm2.1Jane involves: 129S1/Sv * BALB/cJ	lethality during fetal growth through weaning, complete penetrance	J:164805
	spina bifida	J:164805
Grhl3tm1Jane/Grhl3tm3.1Jane Tgm5tm2a(KOMP)Wtsi/Tgm5tm2a(KOMP)Wtsi Tg(KRT14-cre)8Brn/0 involves: 129S1/Sv * C57BL/6N * FVB/N	normal integument phenotype	J:233531
	normal mortality/aging	J:233531
Grhl3tm2.1(F2rl1)Cgh/Grhl3+ either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * C57BL/6 * FVB/N)	epidermal hyperplasia	J:189278
	excessive scratching	J:189278
	scaly skin	J:189278
	skin lesions	J:189278
Grhl3tm2.1(F2rl1)Cgh/Grhl3tm2.1(F2rl1)Cgh either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * C57BL/6 * FVB/N)	perinatal lethality, complete penetrance	J:189278
	spina bifida	J:189278
Grhl3tm2.1Jane/Grhl3tm2.1Jane involves: 129S1/Sv * BALB/cJ	lethality during fetal growth through weaning, complete penetrance	J:164805
	spina bifida	J:164805