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Iqgap2 Gene Detail
Summary
  • Symbol
    Iqgap2
  • Name
    IQ motif containing GTPase activating protein 2
  • Synonyms
    4933417J23Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2449975
    NCBI Gene: 544963
  • Gene Overview
    MyGene.info: IQGAP2
Location & Maps
more
  • Sequence Map
    Chr13:95627177-95891922 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      264746 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 13, 50.26 cM, cytoband D1
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    IQGAP2, IQ motif containing GTPase activating protein 2
  • Vertebrate Orthologs
    9
  • Human Ortholog
    IQGAP2, IQ motif containing GTPase activating protein 2
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 10788
    neXtProt AC: NX_Q13576

  • Chr Location
    5q13.3; chr5:76403255-76708132 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with Iqgap2 mouse models

Human Disease Mouse Models
       Hepatocellular Carcinoma   OMIM: 114550 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotypes from 1 allele in 2 genetic backgrounds
    4 phenotypes from multigenic genotypes
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null mutation display reduced survival with increased incidence of hepatocellular carcinomas, increased hepatocyte apoptosis, and hepatocyte mitochondrial abnormalities.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000021676 Ensembl Gene Model | MGI Sequence Detail 264746 C57BL/6J ±  kb
transcript ENSMUST00000068603 Ensembl | MGI Sequence Detail 5771 Not Applicable  
polypeptide ENSMUSP00000067685 Ensembl | MGI Sequence Detail 1575 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    4092 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 157
    cDNA 155
    Primer pair 2

    Microarray probesets 5
Other
Accession IDs
less
MGI:1918438, MGI:2145287
References
more
  • Summaries
    All 39
    Developmental Gene Expression 6
    Diseases 1
    Gene Ontology 3
    Phenotypes 9
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:233777 Ray JP, et al., The Interleukin-2-mTORc1 Kinase Axis Defines the Signaling, Differentiation, and Metabolism of T Helper 1 and Follicular B Helper T Cells. Immunity. 2015 Oct 20;43(4):690-702

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory