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Iqgap2
Gene Detail
Symbol

Name
ID
Iqgap2
IQ motif containing GTPase activating protein 2
MGI:2449975
Synonyms
4933417J23Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 13
50.26 cM, cytoband D1
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr13:95627177-95891922 bp, - strand
From Ensembl annotation of GRCm38

  264746 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:101543  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: IQGAP2
Gene Tree: Iqgap2

Human
homologs
IQGAP2, IQ motif containing GTPase activating protein 2
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 10788
neXtProt AC: NX_Q13576

Human Chr (Location): 5q13.3; chr5:76403255-76708132 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(17) : Gene trapped(14) Targeted(3)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a null mutation display reduced survival with increased incidence of hepatocellular carcinomas, increased hepatocyte apoptosis, and hepatocyte mitochondrial abnormalities.
 
Human Diseases Modeled in Mice Using Iqgap2 (1)    Mutations Annotated to Human Diseases (1)   
Interactions
Iqgap2 interacts with 293 markers (Mir1b, Mir7-1, Mir9-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (20 annotations)
Process Arp2/3 complex-mediated actin nucleation, regulation of GTPase activity, ...
Component cell surface, cytoplasm, ...
Function actin filament binding, Arp2/3 complex binding, ...
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (184)    Tissues (59)    Images (26)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 168
RT-PCR 16
cDNA source data(155)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase iqgap2    NEW 
Molecular
reagents
All nucleic(157) cDNA(155) Primer pair(2)
Microarray probesets(5)
Other database
links
Ensembl Gene Model ENSMUSG00000021676 (Evidence)
Entrez Gene 544963 (Evidence)
UniGene 38878
DFCI TC1605930, TC1621808, TC1638380
DoTS DT.91410971, DT.101723711
NIA Mouse Gene Index U035057
Consensus CDS Project CCDS36753.1
International Mouse Phenotyping Consortium Status Iqgap2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000021676 Ensembl Gene Model | MGI Sequence Detail 264746 C57BL/6J ±  kb
transcript ENSMUST00000068603 Ensembl | MGI Sequence Detail 5771 Not Applicable 
polypeptide ENSMUSP00000067685 Ensembl | MGI Sequence Detail 1575 Not Applicable 

For the selected sequences
All sequences(40) RefSeq(6) UniProt(7)
Polymorphisms
SNPs within 2kb(4163 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001715 Calponin homology domain
InterPro IPR000048 IQ motif, EF-hand binding site
InterPro IPR000593 RasGAP protein, C-terminal
InterPro IPR001936 Ras GTPase-activating protein
InterPro IPR023152 Ras GTPase-activating protein, conserved site
InterPro IPR008936 Rho GTPase activation protein
InterPro IPR001202 WW domain
Protein Ontology PR:000009096 ras GTPase-activating-like protein IQGAP2
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:205882 Gnatenko DV, et al., Transcript profiling identifies iqgap2(-/-) mouse as a model for advanced human hepatocellular carcinoma. PLoS One. 2013;8(8):e71826
All references(41)
Disease annotation references (1)
Other
accession IDs
MGI:1918438, MGI:2145287

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory