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Phenotypes Associated with This Genotype
Genotype
MGI:5568837
Allelic
Composition		 Iqgap2tm1Vs/Iqgap2tm1Vs
Genetic
Background		 involves: 129S4/SvJae
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Iqgap2tm1Vs mutation (1 available); any Iqgap2 mutation (84 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased hepatocellular carcinoma incidence ( J:205882 )
• mice develop hepatocellular carcinoma that recapitulates molecular features of advanced human hepatocellular carcinoma

liver/biliary system
increased hepatocellular carcinoma incidence ( J:205882 )
• mice develop hepatocellular carcinoma that recapitulates molecular features of advanced human hepatocellular carcinoma

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
hepatocellular carcinoma DOID:684 OMIM:114550
 J:205882

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory