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Disc1
Gene Detail
Symbol

Name
ID
Disc1
disrupted in schizophrenia 1
MGI:2447658
Feature Type
protein coding gene
Genetic Map
Chromosome 8
73.26 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr8:125054195-125261858 bp, + strand
From VEGA annotation of GRCm38

  207664 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:10257  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

HCOP human homology predictions: DISC1
Gene Tree: Disc1

Human
homologs
DISC1, disrupted in schizophrenia 1
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 27185
neXtProt AC: NX_Q9NRI5

Human Synonyms: C1orf136, SCZD9

Human Chr (Location): 1q42.1; chr1:231626815-232041272 (+)  GRCh38.p2

Disease Associations: (2) Diseases Associated with Human DISC1

Mutations,
alleles, and
phenotypes
All mutations/alleles(11) : Chemically induced (ENU)(2) Spontaneous(1) Targeted(3) Transgenic(5)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygotes for a null allele show altered anxiety, synaptic depression, LTP, impulsivity, social investigation, hyperactivity and prepulse inhibition. Homozygotes for a spontaneous allele show altered working memory. Different ENU mutations cause distinct depression and schizophrenia-like profiles.
 
Human Diseases Modeled in Mice Using Disc1 (2)    Mutations Annotated to Human Diseases (7)   
Interactions
Disc1 interacts with 61 markers (Mir22, Mir29b-2, Mir105, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (67 annotations)
Process canonical Wnt signaling pathway, cell proliferation in forebrain, ...
Component axon, cell body, ...
Function kinesin binding, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (14 records)
Data Summary: Results (144)    Tissues (48)    Images (38)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 38
RNA in situ 99
Western blot 7
cDNA source data(4)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: ZFIN disc1    NEW 
Molecular
reagents
All nucleic(8) Genomic(3) cDNA(4) Other(1)
Microarray probesets(1)
Other database
links
VEGA Gene Model OTTMUSG00000032471 (Evidence)
Ensembl Gene Model ENSMUSG00000043051 (Evidence)
Entrez Gene 244667 (Evidence)
UniGene 233504
DFCI TC1591950, TC1727875
DoTS DT.101368711, DT.101368712, DT.101368713, DT.101724222
NIA Mouse Gene Index U040714, U380271
Consensus CDS Project CCDS40517.1, CCDS52707.1
International Mouse Phenotyping Consortium Status Disc1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000032471 VEGA Gene Model | MGI Sequence Detail 207664 C57BL/6J ±  kb
transcript OTTMUST00000080764 VEGA | MGI Sequence Detail 2860 Not Applicable 
polypeptide OTTMUSP00000043041 VEGA | MGI Sequence Detail 852 Not Applicable 

For the selected sequences
All sequences(58) RefSeq(11) UniProt(3)
Polymorphisms
SNPs within 2kb(2450 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR026081 Disrupted in schizophrenia 1
Protein Ontology PR:000006494 disrupted in schizophrenia 1 protein
References
(Earliest) J:80804 Ma L, et al., Cloning and Characterization of Disc1, the Mouse Ortholog of DISC1 (Disrupted-in-Schizophrenia 1). Genomics. 2002 Dec;80(6):662-72
(Latest) J:219862 Okamoto M, et al., DBZ regulates cortical cell positioning and neurite development by sustaining the anterograde transport of Lis1 and DISC1 through control of Ndel1 dual-phosphorylation. J Neurosci. 2015 Feb 18;35(7):2942-58
All references(77)
Disease annotation references (5)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory