Disc1
Gene Detail

Symbol Name ID

Disc1 disrupted in schizophrenia 1 MGI:2447658

Feature Type

protein coding gene

Genetic Map

Chromosome 8

73.26 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr8:125054195-125261858 bp, + strand From VEGA annotation of GRCm38   207664 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:10257  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Gene Tree: Disc1

Human homologs

Human Homolog		DISC1, disrupted in schizophrenia 1
NCBI Gene ID		27185
neXtProt AC		NX_Q9NRI5
Human Synonyms		C1orf136, SCZD9
Human Chr (Location)		1q42.1; chr1:231762561-232177018 (+)  GRCh37.p10
Disease Associations		(2) Diseases Associated with Human DISC1

Alleles and phenotypes

All alleles(5) : Targeted(2) Spontaneous(1) Chemically induced(2)
 

Homozygotes for a null allele show altered anxiety, synaptic depression, LTP, impulsivity, social investigation, hyperactivity and prepulse inhibition. Homozygotes for a spontaneous allele show altered working memory. Different ENU mutations cause distinct depression and schizophrenia-like profiles.

 
Human Diseases Modeled Using Mouse Disc1 (2)    Alleles Annotated to Human Diseases(3)   

Gene Ontology (GO) classifications

All GO classifications: (55 annotations)

Process	canonical Wnt receptor signaling pathway, cell proliferation in forebrain, ...
Component	axon part, cell body, ...
Function	kinesin binding, protein binding, ...

External Resources: FuncBase

Expression

Literature Summary: (13 records)
Data Summary: Results (144)    Tissues (39)    Images (38)
Theiler Stages: 22, 23, 24, 25, 26, 28

Assay Type	Results
Immunohistochemistry	38
RNA in situ	99
Western blot	7

cDNA source data(4)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(8) Genomic(3) cDNA(4) Other(1)
Microarray probesets(1)

Other database links

VEGA Gene Model	OTTMUSG00000032471 (Evidence)
Ensembl Gene Model	ENSMUSG00000043051 (Evidence)
Entrez Gene	244667 (Evidence)
UniGene	233504
DFCI	TC1591950, TC1727875
DoTS	DT.101368711, DT.101368712, DT.101368713, DT.101724222
NIA Mouse Gene Index	U040714, U380271
Consensus CDS Project	CCDS40517.1, CCDS52707.1
International Mouse Knockout Project Status	Disc1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000032471	VEGA Gene Model | MGI Sequence Detail	207664	C57BL/6J
transcript	OTTMUST00000080764	VEGA | MGI Sequence Detail	2860	Not Applicable
polypeptide	OTTMUSP00000043041	VEGA | MGI Sequence Detail	852	Not Applicable

All sequences(51) RefSeq(5) UniProt(2)

Polymorphisms

SNPs(659 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR026081	Disrupted in schizophrenia 1
Protein Ontology	PR:000006494	disrupted in schizophrenia 1 protein

References

(Earliest) J:80804 Ma L, et al., Cloning and Characterization of Disc1, the Mouse Ortholog of DISC1 (Disrupted-in-Schizophrenia 1). Genomics. 2002 Dec;80(6):662-72
(Latest) J:195189 Ritchie D, et al., Disc1 deletion is present in Swiss-derived inbred mouse strains: implications for transgenic studies of learning and memory. Lab Anim. 2013 Apr 5;
All references(65)