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Disc1 Gene Detail
Summary
  • Symbol
    Disc1
  • Name
    disrupted in schizophrenia 1
  • Feature Type
    protein coding gene
  • IDs
    MGI:2447658
    NCBI Gene: 244667
  • Gene Overview
    MyGene.info: DISC1
Location & Maps
more
  • Sequence Map
    Chr8:125054195-125261858 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      207664 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 73.26 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    DISC1, disrupted in schizophrenia 1
  • Vertebrate Orthologs
    8
  • Human Ortholog
    DISC1, disrupted in schizophrenia 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    C1orf136, SCZD9
  • Links
    NCBI Gene ID: 27185
    neXtProt AC: NX_Q9NRI5

  • Chr Location
    1q42.2; chr1:231626815-232041272 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    2 with Disc1 mouse models; 2 with human DISC1 associations

Human Disease Mouse Models
       Schizophrenia; SCZD   OMIM: 181500 View 9 models
       Major Depressive Disorder; MDD   OMIM: 608516 View 1 model
       Schizophrenia 9; SCZD9   OMIM: 604906 View 3 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    10 with disease annotations
  • References
    12 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    47 phenotypes from 8 alleles in 9 genetic backgrounds
    29 phenotypes from multigenic genotypes
    39 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    12
  • Chemically induced (ENU)
    3
  • Spontaneous
    1
  • Targeted
    3
  • Transgenic
    5
  • Incidental Mutations
Homozygotes for a null allele show altered anxiety, synaptic depression, LTP, impulsivity, social investigation, hyperactivity and prepulse inhibition. Homozygotes for a spontaneous allele show altered working memory. Different ENU mutations cause distinct depression and schizophrenia-like profiles.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000032471 VEGA Gene Model | MGI Sequence Detail 207664 C57BL/6J ±  kb
transcript OTTMUST00000080764 VEGA | MGI Sequence Detail 2860 Not Applicable  
polypeptide OTTMUSP00000043041 VEGA | MGI Sequence Detail 852 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    2453 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
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  • All nucleic 8
    Genomic 3
    cDNA 4
    Other 1

    Microarray probesets 1
References
more
  • Summaries
    All 81
    Developmental Gene Expression 15
    Diseases 12
    Gene Ontology 16
    Phenotypes 39
  • Earliest
    J:80804 Ma L, et al., Cloning and Characterization of Disc1, the Mouse Ortholog of DISC1 (Disrupted-in-Schizophrenia 1). Genomics. 2002 Dec;80(6):662-72
  • Latest
    J:235949 Ren J, et al., Interaction between DISC1 and CHL1 in regulation of neurite outgrowth. Brain Res. 2016 Oct 1;1648(Pt A):290-7

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory