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Disc1
Gene Detail
 Symbol
Name
ID
Disc1
disrupted in schizophrenia 1
MGI:2447658
Feature Type protein coding gene
Genetic Map
Chromosome 8
73.26 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr8:125054195-125261858 bp, + strand
From VEGA annotation of GRCm38

  207664 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:10257  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Gene Tree: Disc1

Human
homologs
Human Homolog DISC1, disrupted in schizophrenia 1
NCBI Gene ID 27185
neXtProt AC  NX_Q9NRI5
Human Synonyms  C1orf136, SCZD9
Human Chr (Location)  1q42.1; chr1:231626815-232041272 (+)  GRCh38
Disease Associations  (2) Diseases Associated with Human DISC1
Alleles
and
phenotypes
All alleles(5) : Targeted(2) Spontaneous(1) Chemically induced(2)
 
Homozygotes for a null allele show altered anxiety, synaptic depression, LTP, impulsivity, social investigation, hyperactivity and prepulse inhibition. Homozygotes for a spontaneous allele show altered working memory. Different ENU mutations cause distinct depression and schizophrenia-like profiles.
 
Human Diseases Modeled Using Mouse Disc1 (2)    Alleles Annotated to Human Diseases(3)   
Gene Ontology
(GO)
classifications
All GO classifications: (58 annotations)
Process canonical Wnt signaling pathway, cell proliferation in forebrain, ...
Component axon, cell body, ...
Function kinesin binding, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (13 records)
Data Summary: Results (144)    Tissues (39)    Images (38)
Theiler Stages: 22, 23, 24, 25, 26, 28
Assay TypeResults
Immunohistochemistry 38
RNA in situ 99
Western blot 7
cDNA source data(4)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(8) Genomic(3) cDNA(4) Other(1)
Microarray probesets(1)
Other database
links
VEGA Gene ModelOTTMUSG00000032471 (Evidence)
Ensembl Gene ModelENSMUSG00000043051 (Evidence)
Entrez Gene244667 (Evidence)
UniGene233504
DFCITC1591950, TC1727875
DoTSDT.101368711, DT.101368712, DT.101368713, DT.101724222
NIA Mouse Gene IndexU040714, U380271
Consensus CDS ProjectCCDS40517.1, CCDS52707.1
International Mouse Knockout Project StatusDisc1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000032471 VEGA Gene Model | MGI Sequence Detail 207664 C57BL/6J ±  kb
transcript OTTMUST00000080764 VEGA | MGI Sequence Detail 2860 Not Applicable 
polypeptide OTTMUSP00000043041 VEGA | MGI Sequence Detail 852 Not Applicable 

For the selected sequences
All sequences(57) RefSeq(11) UniProt(2)
Polymorphisms SNPs within 2kb(2450 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR026081 Disrupted in schizophrenia 1
Protein Ontology PR:000006494 disrupted in schizophrenia 1 protein
References (Earliest) J:80804 Ma L, et al., Cloning and Characterization of Disc1, the Mouse Ortholog of DISC1 (Disrupted-in-Schizophrenia 1). Genomics. 2002 Dec;80(6):662-72
(Latest) J:203645 Lepagnol-Bestel AM, et al., A Disc1 mutation differentially affects neurites and spines in hippocampal and cortical neurons. Mol Cell Neurosci. 2013 May;54:84-92
All references(70)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory