Phenotypes Associated with This Genotype

Genotype
MGI:5428306

• Allelic Composition: Tg(Disc1/EGFP)M19Sshe/0
• Genetic Background: involves: C57BL/6JCrl * CBA/CaCrl

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal axon extension ( J:143557 )

• shorter and fewer neurites than on wild-type neurons

abnormal neuron proliferation ( J:143557 )

• newborn mice exhibit reduced neuronal proliferation compared with wild-type mice

abnormal brain interneuron morphology ( J:143557 )

• reduced number of parvalbumin cells in the prefrontal cortex and hippocampus

decreased brain size ( J:143557 )

• reduced brain volume and total surface

enlarged lateral ventricles ( J:143557 )

• 2.3- to 3.0-fold

dilated lateral ventricle ( J:143557 )

• 2.26 times and 2.98 times

decreased corpus callosum size ( J:143557 )

• partial agenesis

• thin and fails to cross the midline above the subcommissural organ

thin cerebral cortex ( J:143557 )

abnormal neurite morphology ( J:143557 )

• shorter and fewer neurites than on wild-type neurons

decreased neuron number ( J:143557 )

• reduced number of parvalbumin cells in the prefrontal cortex and hippocampus

behavior/neurological

abnormal latent inhibition of conditioning behavior ( J:143557 )

• defective

behavioral despair ( J:143557 )

• mice exhibit increased immobility in depression tests compared with wild-type mice

decreased vocalization ( J:143557 )

• mice exhibit reduced stress calls during depression tests compared with wild-type mice

cellular

abnormal axon extension ( J:143557 )

• shorter and fewer neurites than on wild-type neurons

abnormal neuron proliferation ( J:143557 )

• newborn mice exhibit reduced neuronal proliferation compared with wild-type mice

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
schizophrenia		DOID:5419	OMIM:181500	J:143557