Disc1^{tm1(DISC1/DISC1FP1,DISC1FP1/DISC1,DISC1)Xzho}
Targeted Allele Detail

Summary

• Symbol: Disc1^{tm1(DISC1/DISC1FP1,DISC1FP1/DISC1,DISC1)Xzho}
• Name: disrupted in schizophrenia 1; targeted mutation 1, Xianjin Zhou
• MGI ID: MGI:5648808
• Synonyms: DISC1^H
• Gene: Disc1 Location: Chr8:125780934-125988597 bp, + strand Genetic Position: Chr8, 73.26 cM
• Alliance: Disc1^{tm1(DISC1/DISC1FP1,DISC1FP1/DISC1,DISC1)Xzho} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:214737
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S2/SvPasCrl

Mutation description

• Allele Type: Targeted (Conditional ready, Humanized sequence, Inserted expressed sequence, Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Disc1^{tm1(DISC1/DISC1FP1,DISC1FP1/DISC1,DISC1)Xzho} expresses 1 gene
  Knock-in expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  DISC1 (27185)

  Disc1

  (MGI:2447658)

  This allele expresses 2 fusion genes of DISC1 and DISC1FP1

• Mutation details: A floxed cassette containing two human fusion genes, DISC1/DISC1FP1 (DB7) and DISC1FP1/DISC1 (BD13), connected with an IRES followed by a human DISC1 cDNA capped with a splice acceptor site replaced part of exon 1 downstream of the start site via homologous recombination. (J:214737)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Disc1 Mutation: 69 strains or lines available

References

• Original: J:214737 Ji B, et al., Inhibition of protein translation by the DISC1-Boymaw fusion gene from a Scottish family with major psychiatric disorders. Hum Mol Genet. 2014 Nov 1;23(21):5683-705
• All: 1 reference(s)