Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Disc1tm1(DISC1/DISC1FP1,DISC1FP1/DISC1,DISC1)Xzho mutation
(1 available);
any
Disc1 mutation
(69 available)
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behavior/neurological
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• males show a larger increase in total distance traveled, counts, and transitions in locomotion after ketamine injection than sibling controls
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• mice show a large startle variation between individuals with a significant number of mice with low startle (<50)
• however, prepulse inhibition and habituation of acoustic startle are normal
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Disc1del mutation
(19 available);
any
Disc1 mutation
(69 available)
Disc1tm1(DISC1/DISC1FP1,DISC1FP1/DISC1,DISC1)Xzho mutation
(1 available);
any
Disc1 mutation
(69 available)
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growth/size/body
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• males, but nor females, are slightly, but significantly, smaller than control littermates
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• males, but not females, show slightly, but significantly, reduced body weight at P103
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behavior/neurological
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• males show a larger increase in total distance traveled, counts, and transitions in locomotion after ketamine injection in all time blocks except for the first and last one than sibling controls, indicating increased and prolonged responses to ketamine
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• females, but not males, show a lower preference for saccharin than control females
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• mice show more immobility time in the tail suspension test, indicating behavioral despair
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• mice exhibit higher startle with less variation between individuals
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hematopoietic system
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• incomplete penetrance, seen in 2 of 10 males
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• 2 of 10 males show lower concentrations of hemoglobin, indicating different degrees of anemia
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• increase in red blood cell distribution width
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nervous system
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• no gross anatomical abnormalities are seen in the brain
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• mice exhibit enhanced prepulse inhibition (PPI), or impaired prepulse facilitation, when PPI is conducted with a short ISI at 25 ms
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