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Fem1c Gene Detail
Summary
  • Symbol
    Fem1c
  • Name
    fem-1 homolog c (C.elegans)
  • Synonyms
    2610312A07Rik, 3632443A22Rik, mKIAA1785
  • Feature Type
    protein coding gene
  • IDs
    MGI:2444737
    NCBI Gene: 240263
Location & Maps
more
  • Sequence Map
    Chr18:46501746-46525971 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      24226 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 18, 24.62 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    FEM1C, fem-1 homolog C
  • Vertebrate Orthologs
    10
  • Human Ortholog
    FEM1C, fem-1 homolog C
    Orthology source: HomoloGene, HGNC
  • Synonyms
    EUROIMAGE686608, EUROIMAGE783647, FEM1A
  • Links
    NCBI Gene ID: 56929
    neXtProt AC: NX_Q96JP0

  • Chr Location
    5q22; chr5:115520908-115544894 (-)  GRCh38.p2
  • HomoloGene
    Vertebrate Homology Class 10606
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed
  • HCOP
    human homology predictions: FEM1C
  • Gene Tree
    Fem1c
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 2 genetic backgrounds
    8 phenotype references
  • All Mutations and Alleles
    13
  • Gene trapped
    12
  • Targeted
    1
  • Incidental Mutations
    Mutagenetix , APF
Homozygous mutant mice are fertile and show no overt abnormalities.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    2
  • GO References
    1
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    37
  • Tissues
    37
  • cDNA Data
    12
  • Literature Summary
    2
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000042430 VEGA Gene Model | MGI Sequence Detail 24226 C57BL/6J ±  kb
transcript OTTMUST00000111904 VEGA | MGI Sequence Detail 5726 Not Applicable  
polypeptide OTTMUSP00000062753 VEGA | MGI Sequence Detail 617 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    55 from dbSNP Build 142
Protein
Information
less
  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000007456 protein fem-1 homolog C
  • InterPro Domains
    IPR002110 Ankyrin repeat
    IPR020683 Ankyrin repeat-containing domain
Molecular
Reagents
less
  • All nucleic 12
    cDNA 12

    Microarray probesets 6
Other
Accession IDs
less
MGI:1914424, MGI:2147251
References
more
  • Summaries
    All 33
    Developmental Gene Expression 2
    Gene Ontology 1
    Phenotypes 8
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:196753 Pelzel HR, et al., Silencing of Fem1cR3 gene expression in the DBA/2J mouse precedes retinal ganglion cell death and is associated with histone deacetylase activity. Invest Ophthalmol Vis Sci. 2012 Mar;53(3):1428-35
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/20/2016
MGI 6.05 		The Jackson Laboratory