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Tbc1d24 Gene Detail
Summary
  • Symbol
    Tbc1d24
  • Name
    TBC1 domain family, member 24
  • Synonyms
    C530046L02Rik, mKIAA1171
  • Feature Type
    protein coding gene
  • IDs
    MGI:2443456
    NCBI Gene: 224617
  • Gene Overview
    MyGene.info: TBC1D24
Location & Maps
more
  • Sequence Map
    Chr17:24175431-24205562 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      30132 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 12.30 cM
  • Detailed Genetic Map ± 1 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    TBC1D24, TBC1 domain family member 24
  • Vertebrate Orthologs
    10
  • Human Ortholog
    TBC1D24, TBC1 domain family member 24
    Orthology source: HGNC, HomoloGene
  • Synonyms
    DFNA65, DFNB86, DOORS, EIEE16, FIME, TLDC6
  • Links
    NCBI Gene ID: 57465
    neXtProt AC: NX_Q9ULP9

  • Chr Location
    16p13.3; chr16:2475146-2505733 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    2 with human TBC1D24 associations

Human Disease Mouse Models
       Deafness, Autosomal Dominant 65; DFNA65   OMIM: 616044
Deafness, Autosomal Recessive 86; DFNB86   OMIM: 614617
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotype references
  • All Mutations and Alleles
    88
  • Gene trapped
    85
  • Targeted
    3
  • Incidental Mutations
    APF
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000055777 VEGA Gene Model | MGI Sequence Detail 30132 C57BL/6J ±  kb
transcript OTTMUST00000138034 VEGA | MGI Sequence Detail 7265 Not Applicable  
polypeptide OTTMUSP00000072623 VEGA | MGI Sequence Detail 561 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    270 from dbSNP Build 142
Protein
Information
less
  • Protein Ontology
    PR:000016108 TBC1 domain family member 24
Molecular
Reagents
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  • All nucleic 40
    cDNA 40

    Microarray probesets 5
References
more
  • Summaries
    All 27
    Developmental Gene Expression 2
    Gene Ontology 1
    Phenotypes 6
  • Earliest
    J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
  • Latest
    J:230923 Finelli MJ, et al., The Evolutionarily Conserved Tre2/Bub2/Cdc16 (TBC), Lysin Motif (LysM), Domain Catalytic (TLDc) Domain Is Neuroprotective against Oxidative Stress. J Biol Chem. 2016 Feb 5;291(6):2751-63

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/24/2016
MGI 6.04
The Jackson Laboratory