Cdh23^Ahl+
Allele Detail

Summary

• Symbol: Cdh23^Ahl+
• Name: cadherin related 23 (otocadherin); wild-type of age related hearing loss
• MGI ID: MGI:2665714
• Synonyms: Cdh23^753G, Cdh23^CAST, Cdh23^{mdfw-ahl-CAST/Ei}
• Gene: Cdh23 Location: Chr10:60138527-60532269 bp, - strand Genetic Position: Chr10, 30.11 cM
• Alliance: Cdh23^Ahl+ page

Mutation origin

• Strain of Origin: CAST/EiJ

Mutation description

• Allele Type: Not Applicable
• Mutation: Undefined
• Mutation details: This variant of the SNP rs257098870 allele contrasts with the variant of the allele found in C57BL/6J in that a G is present at coding nucleotide position 753 rather than an A. Thus, the G-GT splice donor site is maintained. (J:86905)
• Inheritance: Dominant

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Cdh23 Mutation: 280 strains or lines available

References

• Original: J:44966 Johnson KR, et al., A major gene affecting age-related hearing loss in C57BL/6J mice. Hear Res. 1997 Dec;114(1-2):83-92
• All: 15 reference(s)