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Tet2
Gene Detail
 Symbol
Name
ID
Tet2
tet methylcytosine dioxygenase 2
MGI:2443298
Synonyms Ayu17-449, E130014J05Rik, mKIAA1546
Feature Type protein coding gene
Genetic Map
Chromosome 3
61.84 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr3:133463679-133544390 bp, - strand
From Ensembl annotation of GRCm38

  80712 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:49498  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

Gene Tree: Tet2

Human
homologs
Human Homolog TET2, tet methylcytosine dioxygenase 2
NCBI Gene ID 54790
neXtProt AC  NX_Q6N021
Human Synonyms  KIAA1546, MDS
Human Chr (Location)  4q24; chr4:105145875-105279803 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human TET2
Mutations,
alleles, and
phenotypes
All mutations/alleles(1250) : Gene trapped(1243) Targeted(7)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a gene trapped allele die shortly after birth and exhibit a loss of acidic granules in the proximal convoluted tubules of the kidneys. Mice homozygous for a conditional allele activated in hematopoeitic compartment exhibit self-renewal and myeloid transforamtion.
 
Interactions
Tet2 interacts with 444 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (30 annotations)
Process 5-methylcytosine catabolic process, cell cycle, ...
Component nucleus
Function dioxygenase activity, DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (18)    Tissues (18)    Images (2)
Theiler Stages: 1, 2, 3, 28
Assay TypeResults
RT-PCR 18
cDNA source data(35)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(37) cDNA(35) Primer pair(2)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000040943 (Evidence)
Entrez Gene214133 (Evidence)
UniGene347816
DFCITC1586367, TC1610114, TC1618148, TC1653956
DoTSDT.101365395, DT.101734777, DT.40136293, DT.522267, DT.99839545
NIA Mouse Gene IndexU024673
EC1.14.11.n2
Consensus CDS ProjectCCDS51071.1
International Mouse Knockout Project StatusTet2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000040943 Ensembl Gene Model | MGI Sequence Detail 80712 C57BL/6J ±  kb
transcript ENSMUST00000098603 Ensembl | MGI Sequence Detail 9179 Not Applicable 
polypeptide ENSMUSP00000096203 Ensembl | MGI Sequence Detail 1912 Not Applicable 

For the selected sequences
All sequences(56) RefSeq(17) UniProt(3)
Polymorphisms SNPs within 2kb(244 from dbSNP Build 137)    SNPs within 2kb including multiple locations(246)
Protein-related
information
ResourceIDDescription
InterPro IPR024779 2OGFeDO domain, nucleic acid-modifying type
Protein Ontology PR:000016245 methylcytosine dioxygenase TET2
References (Earliest) J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-le-grand). 1999 Jul;45(5):737-50
(Latest) J:211291 Kunimoto H, et al., Tet2-mutated myeloid progenitors possess aberrant in vitro self-renewal capacity. Blood. 2014 May 1;123(18):2897-9
All references(66)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory