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Tet2
Gene Detail
Symbol

Name
ID
Tet2
tet methylcytosine dioxygenase 2
MGI:2443298
Synonyms
Ayu17-449, E130014J05Rik, mKIAA1546
Feature Type
protein coding gene
Genetic Map
Chromosome 3
61.84 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr3:133463679-133544390 bp, - strand
From Ensembl annotation of GRCm38

  80712 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:49498  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

HCOP human homology predictions: TET2
Gene Tree: Tet2

Human
homologs
TET2, tet methylcytosine dioxygenase 2
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 54790
neXtProt AC: NX_Q6N021

Human Synonyms: KIAA1546, MDS

Human Chr (Location): 4q24; chr4:105145875-105279803 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human TET2

Mutations,
alleles, and
phenotypes
All mutations/alleles(1250) : Gene trapped(1243) Targeted(7)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a gene trapped allele die shortly after birth and exhibit a loss of acidic granules in the proximal convoluted tubules of the kidneys. Mice homozygous for a conditional allele activated in hematopoeitic compartment exhibit self-renewal and myeloid transforamtion.
 
Interactions
Tet2 interacts with 444 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (38 annotations)
Process 5-methylcytosine catabolic process, 5-methylcytosine metabolic process, ...
Component nucleus
Function dioxygenase activity, DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (18)    Tissues (18)    Images (2)    Tissue x Stage Matrix (view)
Assay TypeResults
RT-PCR 18
cDNA source data(35)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase tet2 ; ZFIN tet2    NEW 
Molecular
reagents
All nucleic(37) cDNA(35) Primer pair(2)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000040943 (Evidence)
Entrez Gene 214133 (Evidence)
UniGene 347816
DFCI TC1610114, TC1586367, TC1653956, TC1618148
DoTS DT.99839545, DT.522267, DT.40136293, DT.101734777, DT.101365395
NIA Mouse Gene Index U024673
EC 1.14.11.n2
Consensus CDS Project CCDS51071.1
International Mouse Phenotyping Consortium Status Tet2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000040943 Ensembl Gene Model | MGI Sequence Detail 80712 C57BL/6J ±  kb
transcript ENSMUST00000098603 Ensembl | MGI Sequence Detail 9179 Not Applicable 
polypeptide ENSMUSP00000096203 Ensembl | MGI Sequence Detail 1912 Not Applicable 

For the selected sequences
All sequences(52) RefSeq(13) UniProt(3)
Polymorphisms
SNPs within 2kb(244 from dbSNP Build 137)    SNPs within 2kb including multiple locations(246)
Protein-related
information
ResourceIDDescription
InterPro IPR024779 2OGFeDO domain, nucleic acid-modifying type
Protein Ontology PR:000016245 methylcytosine dioxygenase TET2
References
(Earliest) J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-le-grand). 1999 Jul;45(5):737-50
(Latest) J:220795 Chen E, et al., Distinct effects of concomitant Jak2V617F expression and Tet2 loss in mice promote disease progression in myeloproliferative neoplasms. Blood. 2015 Jan 8;125(2):327-35
All references(73)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/30/2015
MGI 5.22
The Jackson Laboratory