About   Help   FAQ
Tet2 Gene Detail
Summary
  • Symbol
    Tet2
  • Name
    tet methylcytosine dioxygenase 2
  • Synonyms
    Ayu17-449, E130014J05Rik, mKIAA1546
  • Feature Type
    protein coding gene
  • IDs
    MGI:2443298
    NCBI Gene: 214133
Location & Maps
more
  • Sequence Map
    Chr3:133463679-133545139 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      81461 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 61.84 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    TET2, tet methylcytosine dioxygenase 2
  • Vertebrate Orthologs
    9
  • Human Ortholog
    TET2, tet methylcytosine dioxygenase 2
    Orthology source: HomoloGene
  • Synonyms
    KIAA1546, MDS
  • Links
    NCBI Gene ID: 54790
    neXtProt AC: NX_Q6N021

  • Chr Location
    4q24; chr4:105145875-105279803 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 49498
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog
  • HCOP
    human homology predictions: TET2
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with human TET2 associations

Human Disease Mouse Models
       Myelodysplastic Syndrome; MDS   OMIM: 614286
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    45 phenotypes from 6 alleles in 7 genetic backgrounds
    9 phenotypes from multigenic genotypes
    35 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
  • Chemically induced (other)
    1
  • Gene trapped
  • Radiation induced
    1
  • Targeted
    7
  • Genomic Mutations
    2 involving Tet2
  • Incidental Mutations
Mice homozygous for a gene trapped allele die shortly after birth and exhibit a loss of acidic granules in the proximal convoluted tubules of the kidneys. Mice homozygous for a conditional allele activated in hematopoeitic compartment exhibit self-renewal and myeloid transforamtion.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000055135 VEGA Gene Model | MGI Sequence Detail 81461 C57BL/6J ±  kb
transcript OTTMUST00000136527 VEGA | MGI Sequence Detail 9021 Not Applicable  
polypeptide OTTMUSP00000072038 VEGA | MGI Sequence Detail 1920 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    243 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 37
    cDNA 35
    Primer pair 2

    Microarray probesets 3
References
more
  • Summaries
    All 78
    Developmental Gene Expression 6
    Gene Ontology 13
    Phenotypes 35
  • Earliest
    J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-le-grand). 1999 Jul;45(5):737-50
  • Latest
    J:231922 Scourzic L, et al., DNMT3A(R882H) mutant and Tet2 inactivation cooperate in the deregulation of DNA methylation control to induce lymphoid malignancies in mice. Leukemia. 2016 Jun;30(6):1388-98

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
07/19/2016
MGI 6.04
The Jackson Laboratory