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Pag1 Gene Detail
Summary
  • Symbol
    Pag1
  • Name
    phosphoprotein associated with glycosphingolipid microdomains 1
  • Synonyms
    Cbp, F730007C19Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2443160
    NCBI Gene: 94212
  • Gene Overview
    MyGene.info: PAG1
Location & Maps
more
  • Sequence Map
    Chr3:9687479-9833679 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      146201 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 2.47 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    PAG1, phosphoprotein membrane anchor with glycosphingolipid microdomains 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    PAG1, phosphoprotein membrane anchor with glycosphingolipid microdomains 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CBP, PAG
  • Links
    NCBI Gene ID: 55824
    neXtProt AC: NX_Q9NWQ8

  • Chr Location
    8q21.13; chr8:80967810-81112068 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 10198
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed
  • HCOP
    human homology predictions: PAG1
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotypes from 3 alleles in 3 genetic backgrounds
    2 phenotypes from multigenic genotypes
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele are viable and exhibit no apparent defects in embryogenesis, thymic development, or T-cell functions. Mice homozygous for a different knock-out allele show normal T-cell development albeit with an increased thymocyte population.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000033869 VEGA Gene Model | MGI Sequence Detail 146201 C57BL/6J ±  kb
transcript OTTMUST00000085362 VEGA | MGI Sequence Detail 8256 Not Applicable  
polypeptide OTTMUSP00000046110 VEGA | MGI Sequence Detail 429 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    1042 from dbSNP Build 142
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000012231 phosphoprotein associated with glycosphingolipid-enriched microdomains 1
  • InterPro Domains
    IPR032748 Phosphoprotein associated with glycosphingolipid-enriched microdomains 1
Molecular
Reagents
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  • All nucleic 13
    cDNA 12
    Primer pair 1

    Microarray probesets 6
References
more
  • Summaries
    All 28
    Developmental Gene Expression 1
    Gene Ontology 4
    Phenotypes 6
  • Earliest
    J:71006 Brdicka T, et al., Phosphoprotein associated with glycosphingolipid-enriched microdomains (PAG), a novel ubiquitously expressed transmembrane adaptor protein, binds the protein tyrosine kinase csk and is involved in regulation of T cell activation. J Exp Med. 2000 May 1;191(9):1591-604
  • Latest
    J:233777 Ray JP, et al., The Interleukin-2-mTORc1 Kinase Axis Defines the Signaling, Differentiation, and Metabolism of T Helper 1 and Follicular B Helper T Cells. Immunity. 2015 Oct 20;43(4):690-702

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/27/2016
MGI 6.05
The Jackson Laboratory