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Gene Detail
low density lipoprotein receptor-related protein 4
Synonyms 6430526J12Rik, mdig, Megf7
Feature Type protein coding gene
Genetic Map
Chromosome 2
50.63 cM
Detailed Genetic Map ± 1 cM

Mapping data(2)
Sequence Map
Chr2:91457511-91513779 bp, + strand
From VEGA annotation of GRCm38

  56269 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
HomoloGene:17964  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Lrp4

Human Homolog LRP4, low density lipoprotein receptor-related protein 4
NCBI Gene ID 4038
neXtProt AC  NX_O75096
Human Synonyms  CLSS, LRP10, LRP-4, MEGF7, SOST2
Human Chr (Location)  11p11.2; chr11:46856717-46918622 (-)  GRCh38
Disease Associations  (2) Diseases Associated with Human LRP4
alleles, and
All mutations/alleles(14) : Chemically induced (ENU)(2) Spontaneous(3) Targeted(9)
Genomic Mutations involving Lrp4 (2)
Incidental mutations (data from Mutagenetix , APF )
Homozygous mice have malformed digits on all 4 feet, some exhibiting brachydactyly, some syndactyly. Mice homozygous for various targeted mutations exhibit impaired NMJ formation and preweaning lethality.
Human Diseases Modeled Using Mouse Lrp4 (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(5)
Lrp4 interacts with 255 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
All GO classifications: (53 annotations)
Process anatomical structure development, cell differentiation, ...
Component cell surface, dendrite, ...
Function apolipoprotein binding, calcium ion binding, ...
External Resources: FuncBase
Literature Summary: (18 records)
Data Summary: Results (236)    Tissues (78)    Images (62)
Theiler Stages: 2, 3, 5, 9, 10, 11, 14, 15, 17, 18, 19, 20, 21, 23, 24, 25, 26, 27, 28
Assay TypeResults
RNA in situ 170
Northern blot 8
Western blot 3
cDNA source data(13)
External Resources: Allen Institute   GEO   Expression Atlas
All nucleic(20) cDNA(13) Primer pair(5) Other(2)
Microarray probesets(4)
Other database
VEGA Gene ModelOTTMUSG00000014247 (Evidence)
Ensembl Gene ModelENSMUSG00000027253 (Evidence)
Entrez Gene228357 (Evidence)
DFCITC1589510, TC1610677, TC1622477, TC1704919
DoTSDT.55283318, DT.91411395, DT.97394240
NIA Mouse Gene IndexU002125
Consensus CDS ProjectCCDS16432.1
International Mouse Knockout Project StatusLrp4
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000014247 VEGA Gene Model | MGI Sequence Detail 56269 C57BL/6J ±  kb
transcript OTTMUST00000033533 VEGA | MGI Sequence Detail 7926 Not Applicable 
polypeptide OTTMUSP00000015050 VEGA | MGI Sequence Detail 1905 Not Applicable 

For the selected sequences
All sequences(41) RefSeq(7) UniProt(1)
Polymorphisms SNPs within 2kb(339 from dbSNP Build 137)
InterPro IPR001881 EGF-like calcium-binding
InterPro IPR018097 EGF-like calcium-binding, conserved site
InterPro IPR013032 EGF-like, conserved site
InterPro IPR000152 EGF-type aspartate/asparagine hydroxylation site
InterPro IPR000742 Epidermal growth factor-like domain
InterPro IPR009030 Insulin-like growth factor binding protein, N-terminal
InterPro IPR000033 LDLR class B repeat
InterPro IPR023415 Low-density lipoprotein (LDL) receptor class A, conserved site
InterPro IPR002172 Low-density lipoprotein (LDL) receptor class A repeat
InterPro IPR011042 Six-bladed beta-propeller, TolB-like
Protein Ontology PR:000009924 low-density lipoprotein receptor-related protein 4
References (Earliest) J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
(Latest) J:207796 Choi HY, et al., APP interacts with LRP4 and agrin to coordinate the development of the neuromuscular junction in mice. Elife. 2013;2:e00220
All references(59)
Disease annotation references (1)
accession IDs

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 5.19
The Jackson Laboratory