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Lrp4 Gene Detail
Summary
  • Symbol
    Lrp4
  • Name
    low density lipoprotein receptor-related protein 4
  • Synonyms
    6430526J12Rik, mdig, Megf7
  • Feature Type
    protein coding gene
  • IDs
    MGI:2442252
    NCBI Gene: 228357
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:91457511-91513779 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 50.63 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    334 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2442252
protein coding gene Chr2:91457471-91513901 (.)
129S1/SvImJ MGP_129S1SvImJ_G0026150
protein coding gene Chr2:92799400-92858358 (+)
A/J MGP_AJ_G0026111
protein coding gene Chr2:89071233-89127523 (+)
AKR/J MGP_AKRJ_G0026092
protein coding gene Chr2:91536912-91597559 (+)
BALB/cJ MGP_BALBcJ_G0026120
protein coding gene Chr2:89257587-89314670 (+)
C3H/HeJ MGP_C3HHeJ_G0025871
protein coding gene Chr2:91819766-91880758 (+)
C57BL/6NJ MGP_C57BL6NJ_G0026571
protein coding gene Chr2:96048869-96108568 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0023962
protein coding gene Chr2:85575016-85631853 (+)
CAST/EiJ MGP_CASTEiJ_G0025336
protein coding gene Chr2:92367565-92425585 (+)
CBA/J MGP_CBAJ_G0025849
protein coding gene Chr2:99345694-99414152 (+)
DBA/2J MGP_DBA2J_G0025985
protein coding gene Chr2:88672166-88731430 (+)
FVB/NJ MGP_FVBNJ_G0025948
protein coding gene Chr2:87779291-87835468 (+)
LP/J MGP_LPJ_G0026089
protein coding gene Chr2:93002604-93059578 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0025974
protein coding gene Chr2:102365093-102422675 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0026625
protein coding gene Chr2:91610482-91669439 (+)
PWK/PhJ MGP_PWKPhJ_G0025071
protein coding gene Chr2:88405814-88466559 (+)
SPRET/EiJ MGP_SPRETEiJ_G0024872
protein coding gene Chr2:91181632-91240832 (+)
WSB/EiJ MGP_WSBEiJ_G0025403
protein coding gene Chr2:92216584-92274712 (+)



Homology
more
  • Human Ortholog
    LRP4, LDL receptor related protein 4
  • Vertebrate Orthologs
    10
  • Human Ortholog
    LRP4, LDL receptor related protein 4
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CLSS, CMS17, LRP10, LRP-4, MEGF7, SOST2
  • Links
    NCBI Gene ID: 4038
    neXtProt AC: NX_O75096
    UniProt: O75096

  • Chr Location
    11p11.2; chr11:46854715-46918622 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 17964
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: LRP4
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with Lrp4 mouse models; 3 with human LRP4 associations

Human Disease Mouse Models
      
IDs
View 1 model
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    60 phenotypes from 10 alleles in 15 genetic backgrounds
    5 phenotypes from multigenic genotypes
    7 images
    35 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous mutations of this gene cause polysyndactyly. Additional phenotypes may include growth retardation, abnormal incisor development, kidney agenesis, and neonatal lethality associated with respiratory failure.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000027253 Ensembl Gene Model | MGI Sequence Detail 56269 C57BL/6J ±  kb
    transcript ENSMUST00000028689 Ensembl | MGI Sequence Detail 7926 Not Applicable  
    polypeptide ENSMUSP00000028689 Ensembl | MGI Sequence Detail 1905 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      1 Sequence
    • Protein Ontology
      PR:000009924 low-density lipoprotein receptor-related protein 4
    • InterPro Domains
      IPR026823 Complement Clr-like EGF domain
      IPR018097 EGF-like calcium-binding, conserved site
      IPR001881 EGF-like calcium-binding domain
      IPR013032 EGF-like, conserved site
      IPR000742 EGF-like domain
      IPR000152 EGF-type aspartate/asparagine hydroxylation site
      IPR009030 Growth factor receptor cysteine-rich domain superfamily
      IPR000033 LDLR class B repeat
      IPR036055 LDL receptor-like superfamily
      IPR023415 Low-density lipoprotein (LDL) receptor class A, conserved site
      IPR002172 Low-density lipoprotein (LDL) receptor class A repeat
      IPR030799 Low-density lipoprotein receptor-related protein 4
      IPR011042 Six-bladed beta-propeller, TolB-like
    Molecular
    Reagents
    less
    • All nucleic 21
      cDNA 14
      Primer pair 5
      Other 2

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2660807
    References
    more
    • Summaries
      All 80
      Developmental Gene Expression 24
      Diseases 1
      Gene Ontology 17
      Phenotypes 35
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:265947 Kawasaki M, et al., Lrp4/Wise regulates palatal rugae development through Turing-type reaction-diffusion mechanisms. PLoS One. 2018;13(9):e0204126

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory