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Lrp4 Gene Detail
Summary
  • Symbol
    Lrp4
  • Name
    low density lipoprotein receptor-related protein 4
  • Synonyms
    6430526J12Rik, mdig, Megf7
  • Feature Type
    protein coding gene
  • IDs
    MGI:2442252
    NCBI Gene: 228357
Location & Maps
more
  • Sequence Map
    Chr2:91457511-91513779 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      56269 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 50.63 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    LRP4, LDL receptor related protein 4
  • Vertebrate Orthologs
    10
  • Human Ortholog
    LRP4, LDL receptor related protein 4
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CLSS, CMS17, LRP10, LRP-4, MEGF7, SOST2
  • Links
    NCBI Gene ID: 4038
    neXtProt AC: NX_O75096

  • Chr Location
    11p11.2; chr11:46856717-46918622 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 17964
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed
  • HCOP
    human homology predictions: LRP4
  • Gene Tree
Human Diseases
more
  • Diseases
    2 with Lrp4 mouse models; 3 with human LRP4 associations

Human Disease Mouse Models
       Cenani-Lenz Syndactyly Syndrome; CLSS   OMIM: 212780 View 2 models
Sclerosteosis 2; SOST2   OMIM: 614305 View 1 model
       Myasthenic Syndrome, Congenital, 17; CMS17   OMIM: 616304
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    60 phenotypes from 10 alleles in 15 genetic backgrounds
    5 phenotypes from multigenic genotypes
    7 images
    31 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    18
  • Chemically induced (ENU)
    2
  • Chemically induced (other)
    1
  • Radiation induced
    1
  • Spontaneous
    4
  • Targeted
    10
  • Genomic Mutations
    4 involving Lrp4
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000014247 VEGA Gene Model | MGI Sequence Detail 56269 C57BL/6J ±  kb
transcript OTTMUST00000033533 VEGA | MGI Sequence Detail 7926 Not Applicable  
polypeptide OTTMUSP00000015050 VEGA | MGI Sequence Detail 1905 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    334 from dbSNP Build 142
Protein
Information
less
  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000009924 low-density lipoprotein receptor-related protein 4
  • InterPro Domains
    IPR026823 Complement Clr-like EGF domain
    IPR018097 EGF-like calcium-binding, conserved site
    IPR001881 EGF-like calcium-binding domain
    IPR013032 EGF-like, conserved site
    IPR000742 EGF-like domain
    IPR000152 EGF-type aspartate/asparagine hydroxylation site
    IPR009030 Growth factor receptor cysteine-rich domain
    IPR000033 LDLR class B repeat
    IPR023415 Low-density lipoprotein (LDL) receptor class A, conserved site
    IPR002172 Low-density lipoprotein (LDL) receptor class A repeat
    IPR030799 Low-density lipoprotein receptor-related protein 4
    IPR011042 Six-bladed beta-propeller, TolB-like
Molecular
Reagents
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  • All nucleic 20
    cDNA 13
    Primer pair 5
    Other 2

    Microarray probesets 4
Other
Accession IDs
less
MGI:2660807
References
more
  • Summaries
    All 65
    Developmental Gene Expression 20
    Diseases 2
    Gene Ontology 17
    Phenotypes 31
  • Earliest
    J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
  • Latest
    J:224393 Gartz Hanson M, et al., Rectification of muscle and nerve deficits in paralyzed ryanodine receptor type 1 mutant embryos. Dev Biol. 2015 Aug 15;404(2):76-87

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/23/2016
MGI 6.05
The Jackson Laboratory