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Lrp4
Gene Detail
Symbol

Name
ID
Lrp4
low density lipoprotein receptor-related protein 4
MGI:2442252
Synonyms
6430526J12Rik, mdig, Megf7
Feature Type
protein coding gene
Genetic Map
Chromosome 2
50.63 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr2:91457511-91513779 bp, + strand
From VEGA annotation of GRCm38

  56269 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:17964  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: LRP4
Gene Tree: Lrp4

Human
homologs
LRP4, low density lipoprotein receptor-related protein 4
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 4038
neXtProt AC: NX_O75096

Human Synonyms: CLSS, CMS17, LRP10, LRP-4, MEGF7, SOST2

Human Chr (Location): 11p11.2; chr11:46856717-46918622 (-)  GRCh38.p2

Disease Associations: (3) Diseases Associated with Human LRP4

Mutations,
alleles, and
phenotypes
All mutations/alleles(14) : Chemically induced (ENU)(2) Spontaneous(3) Targeted(9)
Genomic Mutations involving Lrp4 (2)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygous mice have malformed digits on all 4 feet, some exhibiting brachydactyly, some syndactyly. Mice homozygous for various targeted mutations exhibit impaired NMJ formation and preweaning lethality.
 
Human Diseases Modeled in Mice Using Lrp4 (1)    Mutations Annotated to Human Diseases (1)    Phenotype Images(5)
Interactions
Lrp4 interacts with 254 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (60 annotations)
Process anatomical structure development, BMP signaling pathway, ...
Component cell surface, dendrite, ...
Function apolipoprotein binding, calcium ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (19 records)
Data Summary: Results (236)    Tissues (78)    Images (62)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 170
Northern blot 8
Western blot 3
RT-PCR 55
cDNA source data(13)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase lrp4    NEW 
Molecular
reagents
All nucleic(20) cDNA(13) Primer pair(5) Other(2)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000014247 (Evidence)
Ensembl Gene Model ENSMUSG00000027253 (Evidence)
Entrez Gene 228357 (Evidence)
DFCI TC1704919, TC1622477, TC1610677, TC1589510
DoTS DT.97394240, DT.91411395, DT.55283318
NIA Mouse Gene Index U002125
Consensus CDS Project CCDS16432.1
International Mouse Phenotyping Consortium Status Lrp4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000014247 VEGA Gene Model | MGI Sequence Detail 56269 C57BL/6J ±  kb
transcript OTTMUST00000033533 VEGA | MGI Sequence Detail 7926 Not Applicable 
polypeptide OTTMUSP00000015050 VEGA | MGI Sequence Detail 1905 Not Applicable 

For the selected sequences
All sequences(41) RefSeq(7) UniProt(1)
Polymorphisms
SNPs within 2kb(339 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001881 EGF-like calcium-binding
InterPro IPR018097 EGF-like calcium-binding, conserved site
InterPro IPR013032 EGF-like, conserved site
InterPro IPR000152 EGF-type aspartate/asparagine hydroxylation site
InterPro IPR000742 Epidermal growth factor-like domain
InterPro IPR009030 Insulin-like growth factor binding protein, N-terminal
InterPro IPR000033 LDLR class B repeat
InterPro IPR023415 Low-density lipoprotein (LDL) receptor class A, conserved site
InterPro IPR002172 Low-density lipoprotein (LDL) receptor class A repeat
InterPro IPR011042 Six-bladed beta-propeller, TolB-like
Protein Ontology PR:000009924 low-density lipoprotein receptor-related protein 4
References
(Earliest) J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
(Latest) J:220309 Xiong L, et al., Lrp4 in osteoblasts suppresses bone formation and promotes osteoclastogenesis and bone resorption. Proc Natl Acad Sci U S A. 2015 Mar 17;112(11):3487-92
All references(63)
Disease annotation references (1)
Other
accession IDs
MGI:2660807

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory