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Lrp4
Gene Detail
Symbol

Name
ID
Lrp4
low density lipoprotein receptor-related protein 4
MGI:2442252
Synonyms
6430526J12Rik, mdig, Megf7
Feature Type
protein coding gene
Genetic Map
Chromosome 2
50.63 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr2:91457511-91513779 bp, + strand
From VEGA annotation of GRCm38

  56269 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:17964  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Lrp4

Human
homologs
Human Homolog LRP4, low density lipoprotein receptor-related protein 4
NCBI Gene ID 4038
neXtProt AC  NX_O75096
Human Synonyms  CLSS, LRP10, LRP-4, MEGF7, SOST2
Human Chr (Location)  11p11.2; chr11:46856717-46918622 (-)  GRCh38
Disease Associations  (2) Diseases Associated with Human LRP4
Mutations,
alleles, and
phenotypes
All mutations/alleles(14) : Chemically induced (ENU)(2) Spontaneous(3) Targeted(9)
Genomic Mutations involving Lrp4 (2)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mice have malformed digits on all 4 feet, some exhibiting brachydactyly, some syndactyly. Mice homozygous for various targeted mutations exhibit impaired NMJ formation and preweaning lethality.
 
Human Diseases Modeled Using Mouse Lrp4 (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(5)
Interactions
Lrp4 interacts with 255 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (53 annotations)
Process anatomical structure development, cell differentiation, ...
Component cell surface, dendrite, ...
Function apolipoprotein binding, calcium ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (19 records)
Data Summary: Results (236)    Tissues (78)    Images (62)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 170
Northern blot 8
Western blot 3
RT-PCR 55
cDNA source data(13)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(20) cDNA(13) Primer pair(5) Other(2)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000014247 (Evidence)
Ensembl Gene ModelENSMUSG00000027253 (Evidence)
Entrez Gene228357 (Evidence)
DFCITC1589510, TC1704919, TC1622477, TC1610677
DoTSDT.91411395, DT.55283318, DT.97394240
NIA Mouse Gene IndexU002125
Consensus CDS ProjectCCDS16432.1
International Mouse Knockout Project StatusLrp4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000014247 VEGA Gene Model | MGI Sequence Detail 56269 C57BL/6J ±  kb
transcript OTTMUST00000033533 VEGA | MGI Sequence Detail 7926 Not Applicable 
polypeptide OTTMUSP00000015050 VEGA | MGI Sequence Detail 1905 Not Applicable 

For the selected sequences
All sequences(41) RefSeq(7) UniProt(1)
Polymorphisms
SNPs within 2kb(339 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001881 EGF-like calcium-binding
InterPro IPR018097 EGF-like calcium-binding, conserved site
InterPro IPR013032 EGF-like, conserved site
InterPro IPR000152 EGF-type aspartate/asparagine hydroxylation site
InterPro IPR000742 Epidermal growth factor-like domain
InterPro IPR009030 Insulin-like growth factor binding protein, N-terminal
InterPro IPR000033 LDLR class B repeat
InterPro IPR023415 Low-density lipoprotein (LDL) receptor class A, conserved site
InterPro IPR002172 Low-density lipoprotein (LDL) receptor class A repeat
InterPro IPR011042 Six-bladed beta-propeller, TolB-like
Protein Ontology PR:000009924 low-density lipoprotein receptor-related protein 4
References
(Earliest) J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
(Latest) J:214694 Kur E, et al., LRP2 mediates folate uptake in the developing neural tube. J Cell Sci. 2014 May 15;127(Pt 10):2261-8
All references(60)
Disease annotation references (1)
Other
accession IDs
MGI:2660807

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory