Lrp4
Gene Detail

Symbol Name ID

Lrp4 low density lipoprotein receptor-related protein 4 MGI:2442252

Synonyms

6430526J12Rik, mdig, Megf7

Feature Type

protein coding gene

Genetic Map

Chromosome 2

50.63 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr2:91457511-91513779 bp, + strand From VEGA annotation of GRCm38   56269 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:17964  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Gene Tree: Lrp4

Human homologs

Human Homolog		LRP4, low density lipoprotein receptor-related protein 4
NCBI Gene ID		4038
neXtProt AC		NX_O75096
Human Synonyms		CLSS, LRP10, LRP-4, MEGF7, SOST2
Human Chr (Location)		11p11.2; chr11:46878268-46940173 (-)  GRCh37.p10
Disease Associations		(2) Diseases Associated with Human LRP4

Alleles and phenotypes

All alleles(11) : Targeted(6) Spontaneous(3) Chemically induced(2)
 

Homozygous mice have malformed digits on all 4 feet, some exhibiting brachydactyly, some syndactyly.

 
Human Diseases Modeled Using Mouse Lrp4 (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(5)

Gene Ontology (GO) classifications

All GO classifications: (29 annotations)

Process	anatomical structure development, cell differentiation, ...
Component	integral to membrane, membrane, ...
Function	calcium ion binding, protein binding, ...

External Resources: FuncBase

Expression

Literature Summary: (17 records)
Data Summary: Results (236)    Tissues (77)    Images (62)
Theiler Stages: 2, 3, 5, 9, 10, 11, 14, 15, 17, 18, 19, 20, 21, 23, 24, 25, 26, 28

Assay Type	Results
RNA in situ	170
Northern blot	8
Western blot	3
RT-PCR	55

cDNA source data(13)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(20) cDNA(13) Primer pair(5) Other(2)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000014247 (Evidence)
Ensembl Gene Model	ENSMUSG00000027253 (Evidence)
Entrez Gene	228357 (Evidence)
DFCI	TC1589510, TC1610677, TC1622477, TC1704919
DoTS	DT.55283318, DT.91411395, DT.97394240
NIA Mouse Gene Index	U002125
Consensus CDS Project	CCDS16432.1
International Mouse Knockout Project Status	Lrp4

Sequences

Length	Strain/Species
genomic	OTTMUSG00000014247	VEGA Gene Model | MGI Sequence Detail	56269	C57BL/6J
transcript	OTTMUST00000033533	VEGA | MGI Sequence Detail	7926	Not Applicable
polypeptide	OTTMUSP00000015050	VEGA | MGI Sequence Detail	1905	Not Applicable

All sequences(38) RefSeq(4) UniProt(1)

Polymorphisms

SNPs(217 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR026823	Complement Clr-like EGF domain
InterPro	IPR001881	EGF-like calcium-binding
InterPro	IPR018097	EGF-like calcium-binding, conserved site
InterPro	IPR013032	EGF-like, conserved site
InterPro	IPR000152	EGF-type aspartate/asparagine hydroxylation site
InterPro	IPR000742	Epidermal growth factor-like domain
InterPro	IPR009030	Insulin-like growth factor binding protein, N-terminal
InterPro	IPR000033	LDLR class B repeat
InterPro	IPR023415	Low-density lipoprotein (LDL) receptor class A, conserved site
InterPro	IPR002172	Low-density lipoprotein (LDL) receptor class A repeat
InterPro	IPR011042	Six-bladed beta-propeller, TolB-like
Protein Ontology	PR:000009924	low-density lipoprotein receptor-related protein 4

References

(Earliest) J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
(Latest) J:194074 Ahn Y, et al., Lrp4 and Wise interplay controls the formation and patterning of mammary and other skin appendage placodes by modulating Wnt signaling. Development. 2013 Feb 1;140(3):583-93
All references(53)

Other accession IDs

MGI:2660807