|
Symbol Name ID |
Lrp4
low density lipoprotein receptor-related protein 4 MGI:2442252 |
| * | Aspects of the system are reported to show a normal phenotype. |
| Darker colors indicate more annotations |
| Human Phenotypes | Frontal bossing |
Thickened calvaria |
Micrognathia |
Mandibular prognathia |
Malar flattening |
Macrocephaly |
Abnormal dental enamel morphology |
Enamel hypoplasia |
Short thumb |
Short finger |
Broad hallux |
Foot oligodactyly |
Toe syndactyly |
Oligodactyly |
Syndactyly |
Cutaneous finger syndactyly |
Finger syndactyly |
Hypoplasia of the radius |
Radioulnar synostosis |
Hypoplasia of the ulna |
Abnormal metacarpal morphology |
Metacarpal synostosis |
Hip dislocation |
Synostosis of carpal bones |
Elbow dislocation |
Micromelia |
Synostosis of joints |
Abnormal rib morphology |
Pectus excavatum |
Scoliosis |
Abnormal form of the vertebral bodies |
Hemivertebrae |
| Disease(s) Associated with LRP4 | ||||||||||||||||||||||||||||||||
| Cenani-Lenz syndactyly syndrome | ||||||||||||||||||||||||||||||||
| sclerosteosis 2 |
| Mouse Phenotypes | skeleton phenotype |
thick neurocranium |
abnormal tooth morphology |
abnormal incisor morphology |
supernumerary incisors |
abnormal molar cusp morphology |
abnormal tooth development |
abnormal enamel morphology |
fused phalanges |
increased femur compact bone thickness |
increased diameter of femur |
fused metacarpal bones |
fused metatarsal bones |
abnormal spine curvature |
increased trabecular bone volume |
abnormal osteocyte morphology |
increased bone trabecula number |
decreased bone trabecular spacing |
increased trabecular bone connectivity density |
increased trabecular bone thickness |
abnormal chondrocyte morphology |
increased bone ossification |
increased bone strength |
|
| Availability | Mouse Genotype | |||||||||||||||||||||||
| Lrp4mdig-2J/Lrp4mdig-2J | ||||||||||||||||||||||||
| Lrp4mdig-3J/Lrp4mdig-3J | ||||||||||||||||||||||||
| Lrp4mitt/Lrp4mitt | ||||||||||||||||||||||||
| Lrp4mte/Lrp4mte | ||||||||||||||||||||||||
| Lrp4tm1.1Pg/Lrp4tm1.1Pg | * | |||||||||||||||||||||||
| Lrp4tm1Her/Lrp4tm1Her | ||||||||||||||||||||||||
| Lrp4tm2Her/Lrp4tm2Her | ||||||||||||||||||||||||
| Lrp4tm1.1Pg/Lrp4+ | ||||||||||||||||||||||||
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/09/2024 MGI 6.23 |
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