Automated description from the Alliance of Genome Resources (Release 7.0.0)
Enables coreceptor activity; protein homodimerization activity; and receptor tyrosine kinase binding activity. Involved in several processes, including positive regulation of Rac protein signal transduction; positive regulation of presynaptic membrane organization; and synapse organization. Acts upstream of or within several processes, including embryonic digit morphogenesis; negative regulation of canonical Wnt signaling pathway; and regionalization. Located in neuromuscular junction and plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; extraembryonic component; eye; and genitourinary system. Used to study sclerosteosis 2. Human ortholog(s) of this gene implicated in Cenani-Lenz syndactyly syndrome; congenital myasthenic syndrome 17; and sclerosteosis 2. Orthologous to human LRP4 (LDL receptor related protein 4).