Txndc2
Gene Detail

Symbol Name ID

Txndc2 thioredoxin domain containing 2 (spermatozoa) MGI:2389312

Synonyms

Sptrx-1

Feature Type

protein coding gene

Genetic Map

Chromosome 17

34.99 cM, cytoband E1.2-E1.3
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr17:65637505-65642204 bp, - strand From NCBI annotation of GRCm38   4700 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Mammalian homology

human; rat; chimpanzee; dog, domestic    (Mammalian Orthology)
Comparative Map (Mouse/Human Txndc2 ± 2 cM)

Gene Tree: Txndc2

Human ortholog

TXNDC2 thioredoxin domain containing 2 (spermatozoa) NCBI Gene ID 84203
Human Synonyms: SPTRX, SPTRX1
Human Chr18:9885723-9888156 bp, + strand Reference GRCh37.p2 Primary Assembly

Alleles and phenotypes

All alleles(3) : Targeted(3)
 

Homozygous mutation of this gene results in increased body size, increased serum phosphorus level and decreased serum IL-6 response to LPS challenge.

 

Gene Ontology (GO) classifications

All GO classifications: (14 annotations)

Process	cell differentiation, cell redox homeostasis, ...
Component	cytoplasm, motile cilium, ...
Function	electron carrier activity, protein disulfide isomerase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (1 records)
Data Summary: Results (4)    Tissues (4)   
Theiler Stages: 15, 25

Assay Type	Results
RNA in situ	4

cDNA source data(14)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(15) cDNA(15)
Microarray probesets(2)

Other database links

Ensembl Gene Model	ENSMUSG00000050612 (Evidence)
Entrez Gene	213272 (Evidence)
UniGene	255732
DFCI	TC1584071
DoTS	DT.101362635, DT.525992
NIA Mouse Gene Index	U038006
Consensus CDS Project	CCDS50165.1
International Mouse Knockout Project Status	Txndc2

Sequences

Length	Strain/Species
genomic	213272	NCBI Gene Model | MGI Sequence Detail	4700	C57BL/6J
transcript	NM_001146002	RefSeq | MGI Sequence Detail	1899	C57BL/6
polypeptide	Q6P902	UniProt | EBI | MGI Sequence Detail	515	Not Applicable

All sequences(21) RefSeq(4) UniProt(2)

Polymorphisms

SNPs(8 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR005746	Thioredoxin
InterPro	IPR013766	Thioredoxin domain
InterPro	IPR012336	Thioredoxin-like fold
Protein Ontology	PR:000016860	thioredoxin domain-containing protein 2

Graphical View of Protein Domain Structure

References

(Earliest) J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
(Latest) J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
All references(26)

Other accession IDs

MGI:2146989