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Txndc2
Gene Detail
 Symbol
Name
ID
Txndc2
thioredoxin domain containing 2 (spermatozoa)
MGI:2389312
Synonyms Sptrx-1
Feature Type protein coding gene
Genetic Map
Chromosome 17
34.99 cM, cytoband E1.2-E1.3
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr17:65637505-65642204 bp, - strand
From NCBI annotation of GRCm38

  4700 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:41856  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog

Gene Tree: Txndc2

Human
homologs
Human Homolog TXNDC2, thioredoxin domain containing 2 (spermatozoa)
NCBI Gene ID 84203
neXtProt AC  NX_Q86VQ3
Human Synonyms  SPTRX, SPTRX1
Human Chr (Location)  18p11.31-p11.2; chr18:9885726-9889275 (+)  GRCh38
Alleles
and
phenotypes
All alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutation of this gene displays normal reproductive system phenotype while results in increased body size, increased serum phosphorus level and decreased serum IL-6 response to LPS challenge.
 
Gene Ontology
(GO)
classifications
All GO classifications: (15 annotations)
Process cell differentiation, cell redox homeostasis, ...
Component cytoplasm, motile cilium, ...
Function protein disulfide isomerase activity, protein disulfide oxidoreductase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (4)    Tissues (4)   
Theiler Stages: 15, 25
Assay TypeResults
RNA in situ 4
cDNA source data(15)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(16) cDNA(16)
Microarray probesets(2)
Other database
links
Ensembl Gene ModelENSMUSG00000050612 (Evidence)
Entrez Gene213272 (Evidence)
UniGene255732
DFCITC1584071
DoTSDT.101362635, DT.525992
NIA Mouse Gene IndexU038006
Consensus CDS ProjectCCDS50165.1
International Mouse Knockout Project StatusTxndc2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 213272 NCBI Gene Model | MGI Sequence Detail 4700 C57BL/6J ±  kb
transcript NM_001146002 RefSeq | MGI Sequence Detail 1899 C57BL/6 
polypeptide Q6P902 UniProt | EBI | MGI Sequence Detail 515 Not Applicable 

For the selected sequences
All sequences(23) RefSeq(6) UniProt(2)
Polymorphisms SNPs within 2kb(16 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR005746 Thioredoxin
InterPro IPR013766 Thioredoxin domain
InterPro IPR012336 Thioredoxin-like fold
Protein Ontology PR:000016860 thioredoxin domain-containing protein 2
Graphical View of Protein Domain Structure
References (Earliest) J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
(Latest) J:205172 Smith TB, et al., Functional deletion of Txndc2 and Txndc3 increases the susceptibility of spermatozoa to age-related oxidative stress. Free Radic Biol Med. 2013 Dec;65:872-81
All references(27)
Other
accession IDs
MGI:2146989

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory