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Txndc2 Gene Detail
Summary
  • Symbol
    Txndc2
  • Name
    thioredoxin domain containing 2 (spermatozoa)
  • Synonyms
    Sptrx-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:2389312
    NCBI Gene: 213272
  • Gene Overview
    MyGene.info: TXNDC2
Location & Maps
more
  • Sequence Map
    Chr17:65637505-65642204 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      4700 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 34.99 cM, cytoband E1.2-E1.3
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    TXNDC2, thioredoxin domain containing 2
  • Vertebrate Orthologs
    6
  • Human Ortholog
    TXNDC2, thioredoxin domain containing 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    SPTRX, SPTRX1
  • Links
    NCBI Gene ID: 84203
    neXtProt AC: NX_Q86VQ3

  • Chr Location
    18p11.31-p11.2; chr18:9885726-9888159 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    8 phenotypes from 2 alleles in 2 genetic backgrounds
    8 phenotypes from multigenic genotypes
    3 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene displays normal reproductive system phenotype while results in increased body size, increased serum phosphorus level and decreased serum IL-6 response to LPS challenge.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000050612 Ensembl Gene Model | MGI Sequence Detail 4700 C57BL/6J ±  kb
transcript ENSMUST00000050236 Ensembl | MGI Sequence Detail 1899 Not Applicable  
polypeptide ENSMUSP00000054909 Ensembl | MGI Sequence Detail 550 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    16 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 16
    cDNA 16

    Microarray probesets 2
Other
Accession IDs
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MGI:2146989
References
more
  • Summaries
    All 24
    Developmental Gene Expression 1
    Gene Ontology 7
    Phenotypes 3
  • Earliest
    J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
  • Latest
    J:205172 Smith TB, et al., Functional deletion of Txndc2 and Txndc3 increases the susceptibility of spermatozoa to age-related oxidative stress. Free Radic Biol Med. 2013 Dec;65:872-81

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory