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Txndc2
Gene Detail
Symbol

Name
ID
Txndc2
thioredoxin domain containing 2 (spermatozoa)
MGI:2389312
Synonyms
Sptrx-1
Feature Type
protein coding gene
Genetic Map
Chromosome 17
34.99 cM, cytoband E1.2-E1.3
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr17:65637505-65642204 bp, - strand
From Ensembl annotation of GRCm38

  4700 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:41856  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog

HCOP human homology predictions: TXNDC2
Gene Tree: Txndc2

Human
homologs
TXNDC2, thioredoxin domain containing 2 (spermatozoa)
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 84203
neXtProt AC: NX_Q86VQ3

Human Synonyms: SPTRX, SPTRX1

Human Chr (Location): 18p11.31-p11.2; chr18:9885726-9888159 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygous mutation of this gene displays normal reproductive system phenotype while results in increased body size, increased serum phosphorus level and decreased serum IL-6 response to LPS challenge.
 
Interactions
Txndc2 interacts with 25 markers (Mir22, Mir30b, Mir103-1, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (1 records)
Data Summary: Results (4)    Tissues (4)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 4
cDNA source data(15)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(16) cDNA(16)
Microarray probesets(2)
Other database
links
Ensembl Gene Model ENSMUSG00000050612 (Evidence)
Entrez Gene 213272 (Evidence)
UniGene 255732
DFCI TC1584071
DoTS DT.101362635, DT.525992
NIA Mouse Gene Index U038006
Consensus CDS Project CCDS50165.1
International Mouse Phenotyping Consortium Status Txndc2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000050612 Ensembl Gene Model | MGI Sequence Detail 4700 C57BL/6J ±  kb
transcript ENSMUST00000050236 Ensembl | MGI Sequence Detail 1899 Not Applicable 
polypeptide ENSMUSP00000054909 Ensembl | MGI Sequence Detail 550 Not Applicable 

For the selected sequences
All sequences(25) RefSeq(8) UniProt(2)
Polymorphisms
SNPs within 2kb(16 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR005746 Thioredoxin
InterPro IPR013766 Thioredoxin domain
InterPro IPR012336 Thioredoxin-like fold
Protein Ontology PR:000016860 thioredoxin domain-containing protein 2
References
(Earliest) J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
(Latest) J:205172 Smith TB, et al., Functional deletion of Txndc2 and Txndc3 increases the susceptibility of spermatozoa to age-related oxidative stress. Free Radic Biol Med. 2013 Dec;65:872-81
All references(27)
Other
accession IDs
MGI:2146989

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory