About   Help   FAQ
Polr2b Gene Detail
Summary
  • Symbol
    Polr2b
  • Name
    polymerase (RNA) II (DNA directed) polypeptide B
  • Synonyms
    MGC:47046, RPB2
  • Feature Type
    protein coding gene
  • IDs
    MGI:2388280
    NCBI Gene: 231329
  • Gene Overview
    MyGene.info: POLR2B
Location & Maps
more
  • Sequence Map
    Chr5:77310147-77349324 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      39178 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 41.66 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    POLR2B, polymerase (RNA) II subunit B
  • Vertebrate Orthologs
    10
  • Human Ortholog
    POLR2B, polymerase (RNA) II subunit B
    Orthology source: HomoloGene
  • Synonyms
    hRPB140, POL2RB, RPB2
  • Links
    NCBI Gene ID: 5431
    neXtProt AC: NX_P30876

  • Chr Location
    4q12; chr4:56978640-57031162 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotype references
  • All Mutations and Alleles
    21
  • Chemically induced (other)
    2
  • Gene trapped
    16
  • Spontaneous
    1
  • Targeted
    2
  • Genomic Mutations
    3 involving Polr2b
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000026994 VEGA Gene Model | MGI Sequence Detail 39178 C57BL/6J ±  kb
transcript OTTMUST00000066713 VEGA | MGI Sequence Detail 4145 Not Applicable  
polypeptide OTTMUSP00000033478 VEGA | MGI Sequence Detail 1174 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    111 from dbSNP Build 142
Protein
Information
less
  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000012988 DNA-directed RNA polymerase II subunit RPB2
  • EC
  • InterPro Domains
    IPR015712 DNA-directed RNA polymerase, subunit 2
    IPR007120 DNA-directed RNA polymerase, subunit 2, domain 6
    IPR007121 RNA polymerase, beta subunit, conserved site
    IPR007644 RNA polymerase, beta subunit, protrusion
    IPR007642 RNA polymerase Rpb2, domain 2
    IPR007645 RNA polymerase Rpb2, domain 3
    IPR007646 RNA polymerase Rpb2, domain 4
    IPR007647 RNA polymerase Rpb2, domain 5
    IPR007641 RNA polymerase Rpb2, domain 7
    IPR014724 RNA polymerase Rpb2, OB-fold
Molecular
Reagents
less
  • All nucleic 10
    cDNA 9
    Primer pair 1

    Microarray probesets 2
References
more
  • Summaries
    All 32
    Developmental Gene Expression 3
    Gene Ontology 6
    Phenotypes 11
  • Earliest
    J:82808 Strausberg RL, et al., Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903
  • Latest
    J:183694 Canella D, et al., A multiplicity of factors contributes to selective RNA polymerase III occupancy of a subset of RNA polymerase III genes in mouse liver. Genome Res. 2012 Apr;22(4):666-80

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
06/22/2016
MGI 6.04
The Jackson Laboratory