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Cmklr2 Gene Detail
Summary
  • Symbol
    Cmklr2
  • Name
    chemerin chemokine-like receptor 2
  • Synonyms
    Gpr1, MGC:41704
  • Feature Type
    protein coding gene
  • IDs
    MGI:2385324
    NCBI Gene: 241070
  • Alliance
    genome feature page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:63221850-63253702 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 32.31 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    789 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2385324
 protein coding gene Chr1:63221737-63253714 (-)
129S1/SvImJ ENSMUSG00200004702
 protein coding gene Chr1:60729369-60761229 (-)
A/J ENSMUSG00195026418
 protein coding gene Chr1:60250822-60282674 (-)
AKR/J ENSMUSG00220037712
 protein coding gene Chr1:60373600-60405458 (-)
BALB/cJ ENSMUSG00180029368
 protein coding gene Chr1:60545927-60577786 (-)
C3H/HeJ ENSMUSG00175000688
 protein coding gene Chr1:60645481-60677329 (-)
C57BL/6NJ ENSMUSG00215015374
 protein coding gene Chr1:60571663-60603513 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014199
 protein coding gene Chr1:57199840-57232391 (-)
CAST/EiJ ENSTCUG00005012498
 protein coding gene Chr1:60409563-60441501 (-)
CBA/J ENSMUSG00210054052
 protein coding gene Chr1:60321362-60353211 (-)
DBA/2J ENSMUSG00185004973
 protein coding gene Chr1:61438232-61470080 (-)
FVB/NJ ENSMUSG00205019185
 protein coding gene Chr1:60274448-60306308 (-)
JF1/MsJ ENSUMUG00000022728
 protein coding gene Chr1:60392660-60424211 (-)
LP/J ENSMUSG00230001982
 protein coding gene Chr1:61438594-61470442 (-)
NOD/ShiLtJ ENSMUSG00190012592
 protein coding gene Chr1:60505303-60537156 (-)
NZO/HlLtJ ENSMUSG00225000903
 protein coding gene Chr1:64663248-64695102 (-)
PWK/PhJ ENSLUMG00010023204
 protein coding gene Chr1:59910664-59942535 (-)
SPRET/EiJ ENSMSPG00010016798
 protein coding gene Chr1:61910455-61938216 (-)
WSB/EiJ ENSIUOG00005018305
 protein coding gene Chr1:60120993-60152868 (-)



Homology
more
  • Human Ortholog
    CMKLR2, chemerin chemokine-like receptor 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CMKLR2, chemerin chemokine-like receptor 2
  • Synonyms
    GPR1
  • Links
    NCBI Gene ID: 2825
    UniProt: P46091

  • Chr Location
    2q33.3; chr2:206175316-206218047 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 1 allele in 1 genetic background
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit increased body weight and estradiol serum levels as well as reduced weight loss in DHEA-treated mice.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    23
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    726
  • Tissues
    63
  • cDNA Data
    20
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000046856 Ensembl Gene Model | MGI Sequence Detail 31853 C57BL/6J ±  kb
    transcript ENSMUST00000050536 Ensembl | MGI Sequence Detail 1940 Not Applicable  
    polypeptide ENSMUSP00000051417 Ensembl | MGI Sequence Detail 353 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 25
      Genomic 1
      cDNA 20
      Primer pair 4

      Microarray probesets 1
    Other
    Accession IDs
    less
    MGI:7382787
    References
    more
    • Summaries
      All 60
      Developmental Gene Expression 7
      Gene Ontology 8
      Phenotypes 18
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory