Trpv3
Gene Detail

Symbol Name ID

Trpv3 transient receptor potential cation channel, subfamily V, member 3 MGI:2181407

Synonyms

1110036I10Rik, Nh, VRL3

Feature Type

protein coding gene

Genetic Map

Chromosome 11

45.25 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr11:73267388-73300363 bp, + strand From VEGA annotation of GRCm38   32976 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:17040  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 dog; 1 chicken

Protein SuperFamily: transient receptor potential cation channel, subfamily V
Gene Tree: Trpv3

Human homologs

Human Homolog		TRPV3, transient receptor potential cation channel, subfamily V, member 3
NCBI Gene ID		162514
neXtProt AC		NX_Q8NET8
Human Synonyms		OLMS, VRL3
Human Chr (Location)		17p13.2; chr17:3413796-3461289 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human TRPV3

Alleles and phenotypes

All alleles(8) : Targeted(7) Spontaneous(1)
 

Homozygous null mice have strong deficits in response to innocuous and noxious heat but not in other sensory modalities.

 
Human Diseases Modeled Using Mouse Trpv3 (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (18 annotations)

Process	calcium ion transmembrane transport, calcium ion transport, ...
Component	integral to membrane, membrane
Function	calcium channel activity, cation channel activity, ...

External Resources: FuncBase

Expression

Literature Summary: (5 records)
Data Summary: Results (50)    Tissues (32)    Images (13)
Theiler Stages: 19, 23, 25, 26, 28

Assay Type	Results
RNA in situ	43
RT-PCR	7

cDNA source data(4)
External Resources: GEO   ArrayExpress

Molecular reagents

All nucleic(5) cDNA(4) Primer pair(1)
Microarray probesets(2)

Other database links

VEGA Gene Model	OTTMUSG00000006137 (Evidence)
Ensembl Gene Model	ENSMUSG00000043029 (Evidence)
Entrez Gene	246788 (Evidence)
DFCI	TC1592894, TC1714952
DoTS	DT.101338671, DT.60102322
NIA Mouse Gene Index	U012900, U012901
Consensus CDS Project	CCDS25004.1
International Mouse Knockout Project Status	Trpv3

Sequences

Length	Strain/Species
genomic	OTTMUSG00000006137	VEGA Gene Model | MGI Sequence Detail	32976	C57BL/6J
transcript	OTTMUST00000013870	VEGA | MGI Sequence Detail	5835	Not Applicable
polypeptide	OTTMUSP00000006438	VEGA | MGI Sequence Detail	791	Not Applicable

All sequences(24) RefSeq(2) UniProt(3)

Polymorphisms

SNPs(39 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR002110	Ankyrin repeat
InterPro	IPR020683	Ankyrin repeat-containing domain
InterPro	IPR005821	Ion transport domain
InterPro	IPR024862	Transient receptor potential channel, vanilloid
InterPro	IPR008347	Transient receptor potential channel, vanilloid 1-4
InterPro	IPR024866	Transient receptor potential channel, vanilloid 3
Protein Ontology	PR:000001060	transient receptor potential cation channel TRPV3

References

(Earliest) J:42153 Haraguchi M, et al., Naturally occurring dermatitis associated with Staphylococcus aureus in DS-Nh mice. Exp Anim. 1997 Jul;46(3):225-9
(Latest) J:189444 Yamamoto-Kasai E, et al., TRPV3 as a therapeutic target for itch. J Invest Dermatol. 2012 Aug;132(8):2109-12
All references(54)

Other accession IDs

MGI:1915950, MGI:2144247, MGI:2384169