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Trpv3
Gene Detail
Symbol

Name
ID
Trpv3
transient receptor potential cation channel, subfamily V, member 3
MGI:2181407
Synonyms
1110036I10Rik, Nh, VRL3
Feature Type
protein coding gene
Genetic Map
Chromosome 11
45.25 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr11:73267388-73300363 bp, + strand
From VEGA annotation of GRCm38

  32976 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:17040  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 dog; 1 chicken; 1 western clawed frog

HCOP human homology predictions: TRPV3
Protein SuperFamily: transient receptor potential cation channel, subfamily V
Gene Tree: Trpv3

Human
homologs
TRPV3, transient receptor potential cation channel, subfamily V, member 3
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 162514
neXtProt AC: NX_Q8NET8

Human Synonyms: FNEPPK2, OLMS, VRL3

Human Chr (Location): 17p13.2; chr17:3510502-3557995 (-)  GRCh38.p2

Disease Associations: (2) Diseases Associated with Human TRPV3

Mutations,
alleles, and
phenotypes
All mutations/alleles(9) : Spontaneous(1) Targeted(8)
Genomic Mutations involving Trpv3 (1)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice have strong deficits in response to innocuous and noxious heat but not in other sensory modalities.
 
Human Diseases Modeled in Mice Using Trpv3 (1)    Mutations Annotated to Human Diseases (1)   
Interactions
Trpv3 interacts with 337 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (18 annotations)
Process calcium ion transmembrane transport, calcium ion transport, ...
Component integral component of membrane, membrane, ...
Function calcium channel activity, cation channel activity, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (50)    Tissues (33)    Images (13)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 43
RT-PCR 7
cDNA source data(4)
Other mouse links: GEO   Expression Atlas
Other vertebrate links: Xenbase trpv3    NEW 
Molecular
reagents
All nucleic(5) cDNA(4) Primer pair(1)
Microarray probesets(2)
Other database
links
VEGA Gene Model OTTMUSG00000006137 (Evidence)
Ensembl Gene Model ENSMUSG00000043029 (Evidence)
Entrez Gene 246788 (Evidence)
DFCI TC1592894, TC1714952
DoTS DT.101338671, DT.60102322
NIA Mouse Gene Index U012900, U012901
PDB 4N5Q
Consensus CDS Project CCDS25004.1
International Mouse Phenotyping Consortium Status Trpv3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000006137 VEGA Gene Model | MGI Sequence Detail 32976 C57BL/6J ±  kb
transcript OTTMUST00000013870 VEGA | MGI Sequence Detail 5835 Not Applicable 
polypeptide OTTMUSP00000006438 VEGA | MGI Sequence Detail 791 Not Applicable 

For the selected sequences
All sequences(38) RefSeq(16) UniProt(3)
Polymorphisms
SNPs within 2kb(162 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002110 Ankyrin repeat
InterPro IPR020683 Ankyrin repeat-containing domain
InterPro IPR005821 Ion transport domain
InterPro IPR008347 Transient receptor potential channel, vanilloid 1-4
InterPro IPR024866 Transient receptor potential channel, vanilloid 3
Protein Ontology PR:000001060 transient receptor potential cation channel TRPV3
References
(Earliest) J:42153 Haraguchi M, et al., Naturally occurring dermatitis associated with Staphylococcus aureus in DS-Nh mice. Exp Anim. 1997 Jul;46(3):225-9
(Latest) J:222171 Cheung SY, et al., Activation of transient receptor potential vanilloid 3 channel suppresses adipogenesis. Endocrinology. 2015 Jun;156(6):2074-86
All references(58)
Disease annotation references (1)
Other
accession IDs
MGI:1915950, MGI:2144247, MGI:2384169

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory