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Trpv3
Gene Detail
 Symbol
Name
ID
Trpv3
transient receptor potential cation channel, subfamily V, member 3
MGI:2181407
Synonyms 1110036I10Rik, Nh, VRL3
Feature Type protein coding gene
Genetic Map
Chromosome 11
45.25 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr11:73267388-73300363 bp, + strand
From VEGA annotation of GRCm38

  32976 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:17040  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 dog; 1 chicken; 1 western clawed frog

Protein SuperFamily: transient receptor potential cation channel, subfamily V
Gene Tree: Trpv3

Human
homologs
Human Homolog TRPV3, transient receptor potential cation channel, subfamily V, member 3
NCBI Gene ID 162514
neXtProt AC  NX_Q8NET8
Human Synonyms  OLMS, VRL3
Human Chr (Location)  17p13.2; chr17:3510502-3557995 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human TRPV3
Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Spontaneous(1) Targeted(7)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice have strong deficits in response to innocuous and noxious heat but not in other sensory modalities.
 
Human Diseases Modeled Using Mouse Trpv3 (1)    Alleles Annotated to Human Diseases(1)   
Interactions
Trpv3 interacts with 338 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (19 annotations)
Process calcium ion transmembrane transport, calcium ion transport, ...
Component integral component of membrane, membrane, ...
Function calcium channel activity, cation channel activity, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (50)    Tissues (32)    Images (13)
Theiler Stages: 19, 23, 25, 26, 28
Assay TypeResults
RNA in situ 43
RT-PCR 7
cDNA source data(4)
External Resources: GEO   Expression Atlas
Molecular
reagents
All nucleic(5) cDNA(4) Primer pair(1)
Microarray probesets(2)
Other database
links
VEGA Gene ModelOTTMUSG00000006137 (Evidence)
Ensembl Gene ModelENSMUSG00000043029 (Evidence)
Entrez Gene246788 (Evidence)
DFCITC1592894, TC1714952
DoTSDT.101338671, DT.60102322
NIA Mouse Gene IndexU012900, U012901
PDB4N5Q
Consensus CDS ProjectCCDS25004.1
International Mouse Knockout Project StatusTrpv3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000006137 VEGA Gene Model | MGI Sequence Detail 32976 C57BL/6J ±  kb
transcript OTTMUST00000013870 VEGA | MGI Sequence Detail 5835 Not Applicable 
polypeptide OTTMUSP00000006438 VEGA | MGI Sequence Detail 791 Not Applicable 

For the selected sequences
All sequences(36) RefSeq(14) UniProt(3)
Polymorphisms SNPs within 2kb(162 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002110 Ankyrin repeat
InterPro IPR020683 Ankyrin repeat-containing domain
InterPro IPR005821 Ion transport domain
InterPro IPR008347 Transient receptor potential channel, vanilloid 1-4
InterPro IPR024866 Transient receptor potential channel, vanilloid 3
Protein Ontology PR:000001060 transient receptor potential cation channel TRPV3
References (Earliest) J:42153 Haraguchi M, et al., Naturally occurring dermatitis associated with Staphylococcus aureus in DS-Nh mice. Exp Anim. 1997 Jul;46(3):225-9
(Latest) J:204138 Carvacho I, et al., TRPV3 Channels Mediate Strontium-Induced Mouse-Egg Activation. Cell Rep. 2013 Dec 12;5(5):1375-86
All references(56)
Disease annotation references (1)
Other
accession IDs
MGI:1915950, MGI:2144247, MGI:2384169

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/19/2014
MGI 5.19
The Jackson Laboratory