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Trpv3 Gene Detail
Summary
  • Symbol
    Trpv3
  • Name
    transient receptor potential cation channel, subfamily V, member 3
  • Synonyms
    1110036I10Rik, Nh, VRL3
  • Feature Type
    protein coding gene
  • IDs
    MGI:2181407
    NCBI Gene: 246788
  • Gene Overview
    MyGene.info: TRPV3
Location & Maps
more
  • Sequence Map
    Chr11:73267388-73300363 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      32976 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 45.25 cM
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    TRPV3, transient receptor potential cation channel subfamily V member 3
  • Vertebrate Orthologs
    7
  • Human Ortholog
    TRPV3, transient receptor potential cation channel subfamily V member 3
    Orthology source: HGNC, HomoloGene
  • Synonyms
    FNEPPK2, OLMS, VRL3
  • Links
    NCBI Gene ID: 162514
    neXtProt AC: NX_Q8NET8

  • Chr Location
    17p13.2; chr17:3510502-3557995 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with Trpv3 mouse models; 2 with human TRPV3 associations

Human Disease Mouse Models
       Dermatitis, Atopic   OMIM: 603165 View 1 model
       Palmoplantar Keratoderma, Mutilating, with Periorificial Keratotic Plaques   OMIM: 614594
Palmoplantar Keratoderma, Nonepidermolytic, Focal 2; FNEPPK2   OMIM: 616400
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    15 phenotypes from 4 alleles in 5 genetic backgrounds
    27 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    10
  • Chemically induced (other)
    1
  • Spontaneous
    1
  • Targeted
    8
  • Genomic Mutations
    2 involving Trpv3
  • Incidental Mutations
Homozygous null mice have strong deficits in response to innocuous and noxious heat but not in other sensory modalities.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000006137 VEGA Gene Model | MGI Sequence Detail 32976 C57BL/6J ±  kb
transcript OTTMUST00000013870 VEGA | MGI Sequence Detail 5835 Not Applicable  
polypeptide OTTMUSP00000006438 VEGA | MGI Sequence Detail 791 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    160 from dbSNP Build 142
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000001060 transient receptor potential cation channel TRPV3
  • PDB
  • InterPro Domains
    IPR002110 Ankyrin repeat
    IPR020683 Ankyrin repeat-containing domain
    IPR005821 Ion transport domain
    IPR008347 Transient receptor potential channel, vanilloid 1-4
    IPR024866 Transient receptor potential channel, vanilloid 3
Molecular
Reagents
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  • All nucleic 5
    cDNA 4
    Primer pair 1

    Microarray probesets 2
Other
Accession IDs
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MGI:1915950, MGI:2144247, MGI:2384169
References
more
  • Summaries
    All 57
    Developmental Gene Expression 5
    Diseases 1
    Gene Ontology 9
    Phenotypes 27
  • Earliest
    J:42153 Haraguchi M, et al., Naturally occurring dermatitis associated with Staphylococcus aureus in DS-Nh mice. Exp Anim. 1997 Jul;46(3):225-9
  • Latest
    J:228934 Hamilton NB, et al., Proton-gated Ca(2+)-permeable TRP channels damage myelin in conditions mimicking ischaemia. Nature. 2016 Jan 28;529(7587):523-7

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory