|Human Homolog||RRM2B, ribonucleotide reductase M2 B (TP53 inducible)|
|NCBI Gene ID||50484|
|Human Synonyms||MTDPS8A, MTDPS8B, P53R2|
|Human Chr (Location)||8q23.1; chr8:102204501-102239118 (-) GRCh38.p2|
|Disease Associations||(2) Diseases Associated with Human RRM2B|
Loss of both functional copies of this gene results in growth retardation, multiple organ failure, and ultimately premature death due to kidney failure. Spontaneous mutation rates and apoptosis are increased in the kidneys due to an attenuation of dNTP pools and a resulting impairment of DNA repair.
|Process||cellular response to DNA damage stimulus, deoxyribonucleoside diphosphate metabolic process, ...|
|Component||cytoplasm, extracellular exosome, ...|
|Function||metal ion binding, oxidoreductase activity, ...|
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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