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Rrm2b Gene Detail
Summary
  • Symbol
    Rrm2b
  • Name
    ribonucleotide reductase M2 B (TP53 inducible)
  • Synonyms
    p53R2
  • Feature Type
    protein coding gene
  • IDs
    MGI:2155865
    NCBI Gene: 382985
  • Gene Overview
    MyGene.info: RRM2B
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:37923952-37961110 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 15, 15.10 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    178 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2155865
protein coding gene Chr15:37923952-37961318 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021804
protein coding gene Chr15:36394879-36446374 (-)
A/J MGP_AJ_G0021764
protein coding gene Chr15:35000990-35042631 (-)
AKR/J MGP_AKRJ_G0021744
protein coding gene Chr15:36029589-36070843 (-)
BALB/cJ MGP_BALBcJ_G0021771
protein coding gene Chr15:35046855-35086632 (-)
C3H/HeJ MGP_C3HHeJ_G0021545
protein coding gene Chr15:35983333-36021257 (-)
C57BL/6NJ MGP_C57BL6NJ_G0022210
protein coding gene Chr15:37824625-37866411 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019747
protein coding gene Chr15:32785477-32819777 (-)
CAST/EiJ MGP_CASTEiJ_G0021062
protein coding gene Chr15:36379236-36416378 (-)
CBA/J MGP_CBAJ_G0021514
protein coding gene Chr15:39032400-39072469 (-)
DBA/2J MGP_DBA2J_G0021638
protein coding gene Chr15:34845262-34884648 (-)
FVB/NJ MGP_FVBNJ_G0021616
protein coding gene Chr15:34246776-34285517 (-)
LP/J MGP_LPJ_G0021708
protein coding gene Chr15:36255739-36305340 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0021640
protein coding gene Chr15:42059187-42100527 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0022233
protein coding gene Chr15:36178715-36218707 (-)
PWK/PhJ MGP_PWKPhJ_G0020806
protein coding gene Chr15:34879403-34916866 (-)
SPRET/EiJ MGP_SPRETEiJ_G0020644
protein coding gene Chr15:35857598-35898842 (-)
WSB/EiJ MGP_WSBEiJ_G0021117
protein coding gene Chr15:36117239-36160948 (-)



Homology
more
  • Human Ortholog
    RRM2B, ribonucleotide reductase regulatory TP53 inducible subunit M2B
  • Vertebrate Orthologs
    9
  • Human Ortholog
    RRM2B, ribonucleotide reductase regulatory TP53 inducible subunit M2B
    Orthology source: HomoloGene, HGNC
  • Synonyms
    MTDPS8A, MTDPS8B, P53R2
  • Links
    NCBI Gene ID: 50484
    neXtProt AC: NX_Q7LG56
    UniProt: Q7LG56

  • Chr Location
    8q22.3; chr8:102204501-102239118 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human RRM2B associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    65 phenotypes from 2 alleles in 2 genetic backgrounds
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Loss of both functional copies of this gene results in growth retardation, multiple organ failure, and ultimately premature death due to kidney failure. Spontaneous mutation rates and apoptosis are increased in the kidneys due to an attenuation of dNTP pools and a resulting impairment of DNA repair.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 382985 NCBI Gene Model | MGI Sequence Detail 37159 C57BL/6J ±  kb
    transcript NM_001357022 RefSeq | MGI Sequence Detail 4705 C57BL/6  
    polypeptide Q6PEE3 UniProt | EBI | MGI Sequence Detail 351 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      7 Sequences
    • EC
    • InterPro Domains
      IPR009078 Ferritin-like superfamily
      IPR012348 Ribonucleotide reductase-like
      IPR033909 Ribonucleotide reductase small subunit
      IPR030475 Ribonucleotide reductase small subunit, acitve site
      IPR000358 Ribonucleotide reductase small subunit family
    Molecular
    Reagents
    less
    • All nucleic 39
      cDNA 39

      Microarray probesets 7
    References
    more
    • Summaries
      All 41
      Developmental Gene Expression 1
      Gene Ontology 8
      Phenotypes 16
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:198487 Chang L, et al., Chromosomal instability triggered by Rrm2b loss leads to IL-6 secretion and plasmacytic neoplasms. Cell Rep. 2013 May 30;3(5):1389-97

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory