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Rrm2b
Gene Detail
 Symbol
Name
ID
Rrm2b
ribonucleotide reductase M2 B (TP53 inducible)
MGI:2155865
Synonyms p53R2
Feature Type protein coding gene
Genetic Map
Chromosome 15
15.10 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr15:37923952-37961318 bp, - strand
From VEGA annotation of GRCm38

  37367 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:56723  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Rrm2b

Human
homologs
Human Homolog RRM2B, ribonucleotide reductase M2 B (TP53 inducible)
NCBI Gene ID 50484
neXtProt AC  NX_Q7LG56
Human Synonyms  MTDPS8A, MTDPS8B, P53R2
Human Chr (Location)  8q23.1; chr8:102204501-102239118 (-)  GRCh38
Disease Associations  (2) Diseases Associated with Human RRM2B
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Gene trapped(2) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Loss of both functional copies of this gene results in growth retardation, multiple organ failure, and ultimately premature death due to kidney failure. Spontaneous mutation rates and apoptosis are increased in the kidneys due to an attenuation of dNTP pools and a resulting impairment of DNA repair.
 
Interactions
Rrm2b interacts with 352 markers (Mir7-1, Mir9-1, Mir9-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (21 annotations)
Process cellular response to DNA damage stimulus, deoxyribonucleoside diphosphate metabolic process, ...
Component cytoplasm, extracellular vesicular exosome, ...
Function metal ion binding, oxidoreductase activity, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (94)    Tissues (94)    Images (12)
Theiler Stages: 22
Assay TypeResults
RNA in situ 94
cDNA source data(38)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(38) cDNA(38)
Microarray probesets(7)
Other database
links
VEGA Gene ModelOTTMUSG00000032790 (Evidence)
Ensembl Gene ModelENSMUSG00000022292 (Evidence)
Entrez Gene382985 (Evidence)
UniGene24738
DFCITC1612851, TC1674174
DoTSDT.101366495, DT.110831061, DT.488821
NIA Mouse Gene IndexU036108, U284907
EC1.17.4.1
Consensus CDS ProjectCCDS27437.1
International Mouse Knockout Project StatusRrm2b
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000032790 VEGA Gene Model | MGI Sequence Detail 37367 C57BL/6J ±  kb
transcript OTTMUST00000081651 VEGA | MGI Sequence Detail 4561 Not Applicable 
polypeptide OTTMUSP00000043707 VEGA | MGI Sequence Detail 351 Not Applicable 

For the selected sequences
All sequences(68) RefSeq(8) UniProt(7)
Polymorphisms SNPs within 2kb(184 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR009078 Ferritin-like superfamily
InterPro IPR012348 Ribonucleotide reductase-related
InterPro IPR000358 Ribonucleotide reductase small subunit
Protein Ontology PR:000014307 ribonucleoside-diphosphate reductase subunit M2 B
References (Earliest) J:72397 Guittet O, et al., Mammalian p53R2 protein forms an active ribonucleotide reductase in vitro with the R1 protein, which is expressed both in resting cells in response to DNA damage and in proliferating cells. J Biol Chem. 2001 Nov 2;276(44):40647-51
(Latest) J:198487 Chang L, et al., Chromosomal instability triggered by Rrm2b loss leads to IL-6 secretion and plasmacytic neoplasms. Cell Rep. 2013 May 30;3(5):1389-97
All references(36)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory