Rrm2b
Gene Detail

Symbol Name ID

Rrm2b ribonucleotide reductase M2 B (TP53 inducible) MGI:2155865

Synonyms

p53R2

Feature Type

protein coding gene

Genetic Map

Chromosome 15

15.10 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr15:37923952-37961318 bp, - strand From VEGA annotation of GRCm38   37367 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:56723  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Rrm2b

Human homologs

Human Homolog		RRM2B, ribonucleotide reductase M2 B (TP53 inducible)
NCBI Gene ID		50484
neXtProt AC		NX_Q7LG56
Human Synonyms		MTDPS8A, MTDPS8B, P53R2
Human Chr (Location)		8q23.1; chr8:103216729-103251346 (-)  GRCh37.p10
Disease Associations		(2) Diseases Associated with Human RRM2B

Alleles and phenotypes

All alleles(5) : Targeted(3) Gene trapped(2)
 

Loss of both functional copies of this gene results in growth retardation, multiple organ failure, and ultimately premature death due to kidney failure. Spontaneous mutation rates and apoptosis are increased in the kidneys due to an attenuation of dNTP pools and a resulting impairment of DNA repair.

 

Gene Ontology (GO) classifications

All GO classifications: (20 annotations)

Process	deoxyribonucleoside diphosphate metabolic process, deoxyribonucleoside triphosphate metabolic process, ...
Component	cytoplasm, mitochondrion, ...
Function	metal ion binding, oxidoreductase activity, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (1 records)
Data Summary: Results (94)    Tissues (94)    Images (12)
Theiler Stages: 22

Assay Type	Results
RNA in situ	94

cDNA source data(39)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(39) cDNA(39)
Microarray probesets(7)

Other database links

VEGA Gene Model	OTTMUSG00000032790 (Evidence)
Ensembl Gene Model	ENSMUSG00000022292 (Evidence)
Entrez Gene	382985 (Evidence)
UniGene	24738
DFCI	TC1612851, TC1674174
DoTS	DT.101366495, DT.110831061, DT.488821
NIA Mouse Gene Index	U036108, U284907
EC	1.17.4.1
Consensus CDS Project	CCDS27437.1
International Mouse Knockout Project Status	Rrm2b

Sequences

Length	Strain/Species
genomic	OTTMUSG00000032790	VEGA Gene Model | MGI Sequence Detail	37367	C57BL/6J
transcript	OTTMUST00000081651	VEGA | MGI Sequence Detail	4561	Not Applicable
polypeptide	OTTMUSP00000043707	VEGA | MGI Sequence Detail	351	Not Applicable

All sequences(62) RefSeq(2) UniProt(7)

Polymorphisms

SNPs(138 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR009078	Ferritin/ribonucleotide reductase-like
InterPro	IPR012348	Ribonucleotide reductase-related
InterPro	IPR000358	Ribonucleotide reductase small subunit
Protein Ontology	PR:000014307	ribonucleoside-diphosphate reductase subunit M2 B

References

(Earliest) J:72397 Guittet O, et al., Mammalian p53R2 protein forms an active ribonucleotide reductase in vitro with the R1 protein, which is expressed both in resting cells in response to DNA damage and in proliferating cells. J Biol Chem. 2001 Nov 2;276(44):40647-51
(Latest) J:122389 Bourdon A, et al., Mutation of RRM2B, encoding p53-controlled ribonucleotide reductase (p53R2), causes severe mitochondrial DNA depletion. Nat Genet. 2007 Jun;39(6):776-80
All references(35)