Loss of both functional copies of this gene results in growth retardation, multiple organ failure, and ultimately premature death due to kidney failure. Spontaneous mutation rates and apoptosis are increased in the kidneys due to an attenuation of dNTP pools and a resulting impairment of DNA repair.
|Process||cellular response to DNA damage stimulus, deoxyribonucleoside diphosphate metabolic process, ...|
|Component||cytoplasm, extracellular exosome, ...|
|Function||metal ion binding, oxidoreductase activity, ...|
|VEGA Gene Model||OTTMUSG00000032790 (Evidence)|
|Ensembl Gene Model||ENSMUSG00000022292 (Evidence)|
|Entrez Gene||382985 (Evidence)|
|DoTS||DT.110831061, DT.488821, DT.101366495|
|Consensus CDS Project||CCDS27437.1|
|International Mouse Phenotyping Consortium Status||Rrm2b|
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update