Go Annotations as Summary Text (Tabular View) (GO Graph)

---

Automated description from the Alliance of Genome Resources (Release 9.0.0)

Enables ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor. Involved in positive regulation of G0 to G1 transition. Acts upstream of or within several processes, including DNA metabolic process; deoxyribonucleotide biosynthetic process; and negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator. Predicted to be located in nucleoplasm. Predicted to be active in cytosol. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in autosomal dominant progressive external ophthalmoplegia with mitochondrial DNA deletions 5 and mitochondrial DNA depletion syndrome 8a. Orthologous to human RRM2B (ribonucleotide reductase regulatory TP53 inducible subunit M2B).

---

---

---

Gene Ontology Evidence Code Abbreviations:

---