Symbol
Name
ID

Rrm2b
ribonucleotide reductase M2 B (TP53 inducible)
MGI:2155865

Phenotype annotations related to homeostasis/metabolism

Darker colors indicate more annotations

Human Phenotypes	Decreased activity of mitochondrial complex IV	Multiple mitochondrial DNA deletions	Increased CSF lactate	Lactic acidosis	Severe lactic acidosis	Aminoaciduria	Exercise intolerance
Disease(s) Associated with RRM2B	Decreased activity of mitochondrial complex IV	Multiple mitochondrial DNA deletions	Increased CSF lactate	Lactic acidosis	Severe lactic acidosis	Aminoaciduria	Exercise intolerance
autosomal dominant progressive external ophthalmoplegia with mitochondrial DNA deletions 5
mitochondrial DNA depletion syndrome 8a

Mouse Phenotypes

increased circulating creatinine level

abnormal blood homeostasis

decreased circulating glucose level

increased circulating cholesterol level

increased circulating triglyceride level

hyperlipidemia

increased circulating phosphate level

decreased circulating alkaline phosphatase level

decreased circulating serum albumin level

increased blood urea nitrogen level

increased urine protein level

abnormal urine homeostasis

Availability

Mouse Genotype

Rrm2b^{Gt(OST85254)Lex}/Rrm2b^{Gt(OST85254)Lex}

Rrm2b^tm1Ynak/Rrm2b^tm1Ynak

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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