About   Help   FAQ
Sp7
Gene Detail
Symbol

Name
ID
Sp7
Sp7 transcription factor 7
MGI:2153568
Synonyms
6430578P22Rik, osterix, Osx
Feature Type
protein coding gene
Genetic Map
Chromosome 15
57.51 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr15:102356609-102366325 bp, - strand
From Ensembl annotation of GRCm38

  9717 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:15607  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

Gene Tree: Sp7

Human
homologs
Human Homolog SP7, Sp7 transcription factor
NCBI Gene ID 121340
neXtProt AC  NX_Q8TDD2
Human Synonyms  OI11, OI12, osterix, OSX
Human Chr (Location)  12q13.13; chr12:53326575-53336220 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human SP7
Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Gene trapped(3) Radiation induced(1) Targeted(6)
Genomic Mutations involving Sp7 (1)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a reporter allele die within minutes of birth displaying cyanosis, respiratory distress, arrested osteoblast differentiation, and failure of endochondral and intramembranous bone formation. Mice homozygous for a knock-out allele exhibit failure of bone ossification.
 
Phenotype Images(4)
Interactions
Sp7 interacts with 195 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (19 annotations)
Process hematopoietic stem cell differentiation, osteoblast differentiation, ...
Component cytoplasm, nucleus
Function DEAD/H-box RNA helicase binding, DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (85 records)
Data Summary: Results (79)    Tissues (56)    Images (12)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 77
RT-PCR 2
cDNA source data(13)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(17) Genomic(1) cDNA(13) Primer pair(1) Other(2)
Microarray probesets(2)
Other database
links
Ensembl Gene ModelENSMUSG00000060284 (Evidence)
Entrez Gene170574 (Evidence)
UniGene263284
DFCITC1744378, TC1585140
DoTSDT.101725551, DT.101725550, DT.55217032
NIA Mouse Gene IndexU036696
Consensus CDS ProjectCCDS37228.1
International Mouse Knockout Project StatusSp7
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000060284 Ensembl Gene Model | MGI Sequence Detail 9717 C57BL/6J ±  kb
transcript ENSMUST00000078508 Ensembl | MGI Sequence Detail 2906 Not Applicable 
polypeptide ENSMUSP00000077596 Ensembl | MGI Sequence Detail 428 Not Applicable 

For the selected sequences
All sequences(29) RefSeq(8) UniProt(5)
Polymorphisms
SNPs within 2kb(41 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR007087 Zinc finger, C2H2
InterPro IPR015880 Zinc finger, C2H2-like
InterPro IPR013087 Zinc finger C2H2-type/integrase DNA-binding domain
Protein Ontology PR:000015445 transcription factor Sp7
References
(Earliest) J:74344 Nakashima K, et al., The novel zinc finger-containing transcription factor osterix is required for osteoblast differentiation and bone formation. Cell. 2002 Jan 11;108(1):17-29
(Latest) J:214984 Gonzalez-Martin MC, et al., Long bone development requires a threshold of Hox function. Dev Biol. 2014 Aug 15;392(2):454-65
All references(132)
Other
accession IDs
MGI:2159409, MGI:2443070

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
12/16/2014
MGI 5.20
The Jackson Laboratory