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Sp7 Gene Detail
Summary
  • Symbol
    Sp7
  • Name
    Sp7 transcription factor 7
  • Synonyms
    6430578P22Rik, osterix, Osx
  • Feature Type
    protein coding gene
  • IDs
    MGI:2153568
    NCBI Gene: 170574
  • Gene Overview
    MyGene.info: SP7
Location & Maps
more
  • Sequence Map
    Chr15:102356609-102366325 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      9717 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 15, 57.51 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    SP7, Sp7 transcription factor
  • Vertebrate Orthologs
    9
  • Human Ortholog
    SP7, Sp7 transcription factor
    Orthology source: HGNC, HomoloGene
  • Synonyms
    OI11, OI12, osterix, OSX
  • Links
    NCBI Gene ID: 121340
    neXtProt AC: NX_Q8TDD2

  • Chr Location
    12q13.13; chr12:53326575-53344793 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 15607
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: SP7
  • Gene Tree
    Sp7
Human Diseases
more
  • Diseases
    1 with human SP7 associations

Human Disease Mouse Models
       Osteogenesis Imperfecta, Type Xii; OI12   OMIM: 613849
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    17 phenotypes from 4 alleles in 6 genetic backgrounds
    4 images
    45 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    12
  • Chemically induced (other)
    1
  • Gene trapped
    3
  • Radiation induced
    2
  • Targeted
    6
  • Genomic Mutations
    3 involving Sp7
  • Incidental Mutations
Mice homozygous for a reporter allele die within minutes of birth displaying cyanosis, respiratory distress, arrested osteoblast differentiation, and failure of endochondral and intramembranous bone formation. Mice homozygous for a knock-out allele exhibit failure of bone ossification.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000060284 Ensembl Gene Model | MGI Sequence Detail 9717 C57BL/6J ±  kb
transcript ENSMUST00000078508 Ensembl | MGI Sequence Detail 2906 Not Applicable  
polypeptide ENSMUSP00000077596 Ensembl | MGI Sequence Detail 428 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    45 from dbSNP Build 142
Protein
Information
less
  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000015445 transcription factor Sp7
  • InterPro Domains
    IPR030450 Transcription factor Sp1 family
    IPR007087 Zinc finger, C2H2
    IPR015880 Zinc finger, C2H2-like
    IPR013087 Zinc finger C2H2-type/integrase DNA-binding domain
Molecular
Reagents
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  • All nucleic 23
    Genomic 1
    cDNA 14
    Primer pair 2
    Other 6

    Microarray probesets 2
Other
Accession IDs
less
MGI:2159409, MGI:2443070
References
more
  • Summaries
    All 145
    Developmental Gene Expression 97
    Diseases 1
    Gene Ontology 8
    Phenotypes 45
  • Earliest
    J:74344 Nakashima K, et al., The novel zinc finger-containing transcription factor osterix is required for osteoblast differentiation and bone formation. Cell. 2002 Jan 11;108(1):17-29
  • Latest
    J:231581 Cesario JM, et al., Expression of forkhead box transcription factor genes Foxp1 and Foxp2 during jaw development. Gene Expr Patterns. 2016 Mar;20(2):111-9

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory