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Sp7
Gene Detail
 Symbol
Name
ID
Sp7
Sp7 transcription factor 7
MGI:2153568
Synonyms 6430578P22Rik, osterix, Osx
Feature Type protein coding gene
Genetic Map
Chromosome 15
57.51 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr15:102357177-102366271 bp, - strand
From NCBI annotation of GRCm38

  9095 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:15607  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 zebrafish

Gene Tree: Sp7

Human
homologs
Human Homolog SP7, Sp7 transcription factor
NCBI Gene ID 121340
neXtProt AC  NX_Q8TDD2
Human Synonyms  OI11, OI12, osterix, OSX
Human Chr (Location)  12q13.13; chr12:53326575-53336220 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human SP7
Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Gene trapped(1) Radiation induced(1) Targeted(6)
Genomic Mutations involving Sp7 (1)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a reporter allele die within minutes of birth displaying cyanosis, respiratory distress, arrested osteoblast differentiation, and failure of endochondral and intramembranous bone formation. Mice homozygous for a knock-out allele exhibit failure of bone ossification.
 
Phenotype Images(4)
Interactions
Sp7 interacts with 195 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (19 annotations)
Process hematopoietic stem cell differentiation, osteoblast differentiation, ...
Component cytoplasm, nucleus
Function DEAD/H-box RNA helicase binding, DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (76 records)
Data Summary: Results (79)    Tissues (56)    Images (12)
Theiler Stages: 15, 17, 19, 21, 22, 23, 25, 26, 28
Assay TypeResults
RNA in situ 77
RT-PCR 2
cDNA source data(13)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(17) Genomic(1) cDNA(13) Primer pair(1) Other(2)
Microarray probesets(2)
Other database
links
Ensembl Gene ModelENSMUSG00000060284 (Evidence)
Entrez Gene170574 (Evidence)
UniGene263284
DFCITC1585140, TC1744378
DoTSDT.101725550, DT.101725551, DT.55217032
NIA Mouse Gene IndexU036696
Consensus CDS ProjectCCDS37228.1
International Mouse Knockout Project StatusSp7
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 170574 NCBI Gene Model | MGI Sequence Detail 9095 C57BL/6J ±  kb
transcript NM_130458 RefSeq | MGI Sequence Detail 2284 Not Specified 
polypeptide Q8VI67 UniProt | EBI | MGI Sequence Detail 428 Not Applicable 

For the selected sequences
All sequences(27) RefSeq(8) UniProt(3)
Polymorphisms SNPs within 2kb(39 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR007087 Zinc finger, C2H2
InterPro IPR015880 Zinc finger, C2H2-like
InterPro IPR013087 Zinc finger C2H2-type/integrase DNA-binding domain
Protein Ontology PR:000015445 transcription factor Sp7
Graphical View of Protein Domain Structure
References (Earliest) J:74344 Nakashima K, et al., The novel zinc finger-containing transcription factor osterix is required for osteoblast differentiation and bone formation. Cell. 2002 Jan 11;108(1):17-29
(Latest) J:208432 Schwarz D, et al., Ezh2 is required for neural crest-derived cartilage and bone formation. Development. 2014 Feb;141(4):867-77
All references(124)
Other
accession IDs
MGI:2159409, MGI:2443070

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory