Sp7
Gene Detail

Symbol Name ID

Sp7 Sp7 transcription factor 7 MGI:2153568

Synonyms

6430578P22Rik, osterix, Osx

Feature Type

protein coding gene

Genetic Map

Chromosome 15

57.51 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr15:102357177-102366271 bp, - strand From NCBI annotation of GRCm38   9095 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:15607  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 zebrafish

Gene Tree: Sp7

Human homologs

Human Homolog		SP7, Sp7 transcription factor
NCBI Gene ID		121340
neXtProt AC		NX_Q8TDD2
Human Synonyms		OI11, OI12, osterix, OSX
Human Chr (Location)		12q13.13; chr12:53720359-53730004 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human SP7

Alleles and phenotypes

All alleles(7) : Targeted(6) Gene trapped(1)
 

Mice homozygous for a reporter allele die within minutes of birth displaying cyanosis, respiratory distress, arrested osteoblast differentiation, and failure of endochondral and intramembranous bone formation. Mice homozygous for a knock-out allele exhibit failure of bone ossification.

 

Gene Ontology (GO) classifications

All GO classifications: (18 annotations)

Process	hematopoietic stem cell differentiation, osteoblast differentiation, ...
Component	cytoplasm, nucleus
Function	DEAD/H-box RNA helicase binding, DNA binding, ...

External Resources: FuncBase

Expression

Literature Summary: (68 records)
Data Summary: Results (76)    Tissues (54)    Images (10)
Theiler Stages: 15, 17, 19, 21, 22, 23, 26, 28

Assay Type	Results
RNA in situ	74
RT-PCR	2

cDNA source data(12)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(16) Genomic(1) cDNA(12) Primer pair(1) Other(2)
Microarray probesets(2)

Other database links

Ensembl Gene Model	ENSMUSG00000060284 (Evidence)
Entrez Gene	170574 (Evidence)
UniGene	263284
DFCI	TC1585140, TC1744378
DoTS	DT.101725550, DT.101725551, DT.55217032
NIA Mouse Gene Index	U036696
Consensus CDS Project	CCDS37228.1
International Mouse Knockout Project Status	Sp7

Sequences

Length	Strain/Species
genomic	170574	NCBI Gene Model | MGI Sequence Detail	9095	C57BL/6J
transcript	NM_130458	RefSeq | MGI Sequence Detail	2284	Not Specified
polypeptide	Q8VI67	UniProt | EBI | MGI Sequence Detail	428	Not Applicable

All sequences(21) RefSeq(2) UniProt(3)

Polymorphisms

SNPs within 2kb(39 from dbSNP Build 137)

Protein-related information

Resource	ID	Description
InterPro	IPR007087	Zinc finger, C2H2
InterPro	IPR015880	Zinc finger, C2H2-like
InterPro	IPR013087	Zinc finger C2H2-type/integrase DNA-binding domain
Protein Ontology	PR:000015445	transcription factor Sp7

Graphical View of Protein Domain Structure

References

(Earliest) J:74344 Nakashima K, et al., The novel zinc finger-containing transcription factor osterix is required for osteoblast differentiation and bone formation. Cell. 2002 Jan 11;108(1):17-29
(Latest) J:193883 Ortuno MJ, et al., Osterix induces Col1a1 gene expression through binding to Sp1 sites in the bone enhancer and proximal promoter regions. Bone. 2013 Feb;52(2):548-56
All references(112)

Other accession IDs

MGI:2159409, MGI:2443070