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Sp7 Gene Detail
Summary
  • Symbol
    Sp7
  • Name
    Sp7 transcription factor 7
  • Synonyms
    6430578P22Rik, osterix, Osx
  • Feature Type
    protein coding gene
  • IDs
    MGI:2153568
    NCBI Gene: 170574
  • Alliance
    genome feature page
  • Transcription Start Sites
    4 TSS
  • Regulated by
    Rr283 (1 regulatory region)
Location &
Maps
more
  • Sequence Map
    Chr15:102265038-102275498 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 57.51 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    196 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2153568
 protein coding gene Chr15:102265038-102275617 (-)
129S1/SvImJ ENSMUSG00200048995
 protein coding gene Chr15:99490070-99500578 (-)
A/J ENSMUSG00195037317
 protein coding gene Chr15:99379620-99389958 (-)
AKR/J ENSMUSG00220049147
 protein coding gene Chr15:99350161-99360678 (-)
BALB/cJ ENSMUSG00180041018
 protein coding gene Chr15:99262576-99272946 (-)
C3H/HeJ ENSMUSG00175044216
 protein coding gene Chr15:99581495-99591833 (-)
C57BL/6NJ ENSMUSG00215049443
 protein coding gene Chr15:99306014-99316383 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020349
 protein coding gene Chr15:96190697-96201005 (-)
CAST/EiJ ENSTCUG00005045596
 protein coding gene Chr15:98786329-98796692 (-)
CBA/J ENSMUSG00210026508
 protein coding gene Chr15:99332669-99343007 (-)
DBA/2J ENSMUSG00185038466
 protein coding gene Chr15:99350020-99360520 (-)
FVB/NJ ENSMUSG00205039360
 protein coding gene Chr15:99054549-99065045 (-)
JF1/MsJ ENSUMUG00000044571
 protein coding gene Chr15:98810546-98821095 (-)
LP/J ENSMUSG00230005819
 protein coding gene Chr15:102711117-102721617 (-)
NOD/ShiLtJ ENSMUSG00190027984
 protein coding gene Chr15:99294870-99305374 (-)
NZO/HlLtJ ENSMUSG00225027311
 protein coding gene Chr15:102890936-102901448 (-)
PWK/PhJ ENSLUMG00010048543
 protein coding gene Chr15:99021835-99032323 (-)
SPRET/EiJ ENSMSPG00010048823
 protein coding gene Chr15:100811585-100821868 (-)
WSB/EiJ ENSIUOG00005030010
 protein coding gene Chr15:99439764-99450265 (-)



Homology
more
  • Human Ortholog
    SP7, Sp7 transcription factor
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SP7, Sp7 transcription factor
  • Synonyms
    OI11, OI12, osterix, OSX
  • Links
    NCBI Gene ID: 121340
    UniProt: Q8TDD2

  • Chr Location
    12q13.13; chr12:53326575-53345315 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human SP7 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    24 phenotypes from 6 alleles in 8 genetic backgrounds
    19 phenotypes from multigenic genotypes
    4 images
    91 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a reporter allele die within minutes of birth displaying cyanosis, respiratory distress, arrested osteoblast differentiation, and failure of endochondral and intramembranous bone formation. Mice homozygous for a knock-out allele exhibit failure of bone ossification.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    38
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1105
  • Tissues
    214
  • cDNA Data
    17
  • Literature Summary
    254
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 170574 NCBI Gene Model | MGI Sequence Detail 10461 C57BL/6J ±  kb
    transcript NM_001348205 RefSeq | MGI Sequence Detail 3051 C57BL/6  
    polypeptide Q8VI67 UniProt | EBI | MGI Sequence Detail 428 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 58
      Genomic 2
      cDNA 18
      Primer pair 18
      Other 20
      Antibodies 12

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGI:2159409, MGI:2443070
    References
    more
    • Summaries
      All 521
      Developmental Gene Expression 254
      Diseases 1
      Gene Ontology 12
      Phenotypes 91
    • Earliest
      J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
    • Latest
      J:391326 Chae SA, et al., Maternal Exercise Rescues Embryonic Osteogenesis Impaired due to POLG Mutation Through a Potential Apelin-ATF4 Axis. Adv Sci (Weinh). 2026 Aug 7;:e77029
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory