Symbol
Name
ID

Sp7
Sp7 transcription factor 7
MGI:2153568

Phenotype annotations related to skeleton

Darker colors indicate more annotations

Human Phenotypes

Brachyturricephaly

Micrognathia

Wormian bones

Dentinogenesis imperfecta

Bowing of the long bones

Bowing of the arm

Bowing of the legs

Hyperextensibility of the finger joints

Hypermobility of interphalangeal joints

Recurrent fractures

Pectus carinatum

Scoliosis

Osteoporosis

Generalized osteoporosis

Disease(s) Associated with SP7

osteogenesis imperfecta type 12

Mouse Phenotypes

abnormal osteoblast differentiation

abnormal limb bone morphology

clavicle hypoplasia

abnormal axial skeleton morphology

abnormal rib morphology

abnormal vertebrae morphology

abnormal trabecular bone morphology

abnormal skeleton development

abnormal bone ossification

abnormal bone mineralization

rickets

failure of endochondral bone ossification

failure of bone ossification

Availability

Mouse Genotype

Sp7^tm1.1Rnis/Sp7^tm1.1Rnis

Sp7^tm1Crm/Sp7^tm1Crm

Sp7^tm1Rnis/Sp7^tm1Rnis
Tg(Col11a2-cre)1Ntsu/0 (conditional)

Sp7^tm1Rnis/Sp7^tm1Rnis
Tg(Col2a1-cre)1Bhr/0 (conditional)

Sp7^tm1Rnis/Sp7^tm1Rnis
Tg(Prrx1-cre)1Cjt/0 (conditional)

Sox9^tm3(cre)Crm/Sox9⁺
Sp7^tm1Crm/Sp7^tm2Crm (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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