Sp7 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Sp7
Sp7 transcription factor 7
MGI:2153568

18 phenotypes from 5 alleles in 7 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Sox9^tm3(cre)Crm/Sox9⁺ Sp7^tm1Crm/Sp7^tm2Crm involves: 129S7/SvEvBrd * C57BL/6 * SJL	abnormal axial skeleton morphology	J:102495
	abnormal bone mineralization	J:102495
	abnormal bone ossification	J:102495
	abnormal limb bone morphology	J:102495
	abnormal osteoblast differentiation	J:102495
	abnormal rib morphology	J:102495
	abnormal skeleton development	J:102495
	abnormal trabecular bone morphology	J:102495
	abnormal vertebrae morphology	J:102495
	neonatal lethality, complete penetrance	J:102495
Sp7^tm1.1Amc/Sp7^tm1.1Amc involves: 129S4/SvJae * C57BL/6 * CBA	no abnormal phenotype detected	J:235520
Sp7^tm1.1Rnis/Sp7^tm1.1Rnis involves: C57BL * C57BL/6NCrlj * CBA/JNCrlj * DBA	abnormal skeleton development	J:191589
	failure of bone ossification	J:191589
	failure of endochondral bone ossification	J:191589
Sp7^tm1Crm/Sp7^tm1Crm involves: 129S7/SvEvBrd * C57BL/6	abnormal axial skeleton morphology	J:74344
	abnormal bone mineralization	J:74344
	abnormal limb morphology	J:74344
	abnormal rib morphology	J:74344
	abnormal vertebrae morphology	J:74344
	clavicle hypoplasia	J:74344
	cyanosis	J:74344
	neonatal lethality, complete penetrance	J:74344
	respiratory distress	J:74344
Sp7^tm1Rnis/Sp7^tm1Rnis Tg(Col2a1-cre)1Bhr/0 involves: C57BL * C57BL/6 * CBA/JNCrlj * SJL	abnormal skeleton development	J:191589
	failure of endochondral bone ossification	J:191589
	rickets	J:191589
Sp7^tm1Rnis/Sp7^tm1Rnis Tg(Col11a2-cre)1Ntsu/0 involves: C57BL * C57BL/6 * CBA/JNCrlj * DBA/2	failure of endochondral bone ossification	J:191589
Sp7^tm1Rnis/Sp7^tm1Rnis Tg(Prrx1-cre)1Cjt/0 involves: C57BL * C57BL/6 * CBA/JNCrlj * SJL/J	failure of endochondral bone ossification	J:191589

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/23/2024 MGI 6.23