Cldn16
Gene Detail

Symbol Name ID

Cldn16 claudin 16 MGI:2148742

Synonyms

claudin-16, paracellin-1, PCLN1

Feature Type

protein coding gene

Genetic Map

Chromosome 16

18.10 cM, cytoband B2
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr16:26463135-26482765 bp, + strand From VEGA annotation of GRCm38   19631 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:4799  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken

Gene Tree: Cldn16

Human homologs

Human Homolog		CLDN16, claudin 16
NCBI Gene ID		10686
neXtProt AC		NX_Q9Y5I7
Human Synonyms		HOMG3, PCLN1
Human Chr (Location)		3q28; chr3:190105661-190129932 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human CLDN16

Alleles and phenotypes

All alleles(5) : Targeted(5)
 

Mice homozygous for a null allele display an age-dependent progressive phenotype that includes hypercalciuria and hypomagnesemia, significantly elevated serum parathyroid hormone and calcitriol (1,25(OH)2D3) levels, and a significantly lower urinary pH but no nephrocalcinosis or renal failure.

 

Gene Ontology (GO) classifications

All GO classifications: (12 annotations)

Process	ion transport, positive regulation of calcium ion transport, ...
Component	cell junction, integral to membrane, ...
Function	structural molecule activity

External Resources: FuncBase

Expression

Literature Summary: (3 records)
Data Summary: Results (8)    Tissues (6)   
Theiler Stages: 20, 22, 23, 24, 26, 28

Assay Type	Results
Immunohistochemistry	3
RT-PCR	5

cDNA source data(5)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(6) cDNA(5) Primer pair(1)
Microarray probesets(2)

Other database links

VEGA Gene Model	OTTMUSG00000028402 (Evidence)
Ensembl Gene Model	ENSMUSG00000038148 (Evidence)
Entrez Gene	114141 (Evidence)
UniGene	275205
DFCI	TC1591589, TC1619799
DoTS	DT.55199526
NIA Mouse Gene Index	U016975
Consensus CDS Project	CCDS28088.1
International Mouse Knockout Project Status	Cldn16

Sequences

Length	Strain/Species
genomic	OTTMUSG00000028402	VEGA Gene Model | MGI Sequence Detail	19631	C57BL/6J
transcript	OTTMUST00000070376	VEGA | MGI Sequence Detail	1173	Not Applicable
polypeptide	OTTMUSP00000035856	VEGA | MGI Sequence Detail	235	Not Applicable

All sequences(25) RefSeq(2) UniProt(2)

Polymorphisms

SNPs(90 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR006187	Claudin
InterPro	IPR003927	Claudin-16
InterPro	IPR017974	Claudin, conserved site
InterPro	IPR004031	PMP-22/EMP/MP20/Claudin
Protein Ontology	PR:000005543	claudin-16

References

(Earliest) J:73057 Weber S, et al., Primary gene structure and expression studies of rodent paracellin-1. J Am Soc Nephrol. 2001 Dec;12(12):2664-72
(Latest) J:181271 Westmoreland JJ, et al., Dynamic distribution of claudin proteins in pancreatic epithelia undergoing morphogenesis or neoplastic transformation. Dev Dyn. 2012 Mar;241(3):583-94
All references(36)