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Cldn16
Gene Detail
Symbol

Name
ID
Cldn16
claudin 16
MGI:2148742
Synonyms
claudin-16, paracellin-1, PCLN1
Feature Type
protein coding gene
Genetic Map
Chromosome 16
18.10 cM, cytoband B2
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr16:26463135-26482765 bp, + strand
From VEGA annotation of GRCm38

  19631 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4799  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

HCOP human homology predictions: CLDN16
Gene Tree: Cldn16

Human
homologs
CLDN16, claudin 16
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 10686
neXtProt AC: NX_Q9Y5I7

Human Synonyms: HOMG3, PCLN1

Human Chr (Location): 3q28; chr3:190387872-190412143 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human CLDN16

Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Targeted(5)
 
Mice homozygous for a null allele display an age-dependent progressive phenotype that includes hypercalciuria and hypomagnesemia, significantly elevated serum parathyroid hormone and calcitriol (1,25(OH)2D3) levels, and a significantly lower urinary pH but no nephrocalcinosis or renal failure.
 
Interactions
Cldn16 interacts with 18 markers (Mir30a, Mir30b, Mir30c-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (12 annotations)
Process ion transport, positive regulation of calcium ion transport, ...
Component bicellular tight junction, cell junction, ...
Function structural molecule activity
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (8)    Tissues (6)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 3
RT-PCR 5
cDNA source data(5)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase cldn16    NEW 
Molecular
reagents
All nucleic(6) cDNA(5) Primer pair(1)
Microarray probesets(2)
Other database
links
VEGA Gene Model OTTMUSG00000028402 (Evidence)
Ensembl Gene Model ENSMUSG00000038148 (Evidence)
Entrez Gene 114141 (Evidence)
UniGene 275205
DFCI TC1591589, TC1619799
DoTS DT.55199526
NIA Mouse Gene Index U016975
Consensus CDS Project CCDS28088.1
International Mouse Phenotyping Consortium Status Cldn16
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000028402 VEGA Gene Model | MGI Sequence Detail 19631 C57BL/6J ±  kb
transcript OTTMUST00000070377 VEGA | MGI Sequence Detail 950 Not Applicable 
polypeptide OTTMUSP00000035857 VEGA | MGI Sequence Detail 235 Not Applicable 

For the selected sequences
All sequences(25) RefSeq(2) UniProt(2)
Polymorphisms
SNPs within 2kb(96 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR006187 Claudin
InterPro IPR003927 Claudin-16
InterPro IPR017974 Claudin, conserved site
InterPro IPR004031 PMP-22/EMP/MP20/Claudin
Protein Ontology PR:000005543 claudin-16
References
(Earliest) J:73057 Weber S, et al., Primary gene structure and expression studies of rodent paracellin-1. J Am Soc Nephrol. 2001 Dec;12(12):2664-72
(Latest) J:181271 Westmoreland JJ, et al., Dynamic distribution of claudin proteins in pancreatic epithelia undergoing morphogenesis or neoplastic transformation. Dev Dyn. 2012 Mar;241(3):583-94
All references(34)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory