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Sf3b1
Gene Detail
Symbol

Name
ID
Sf3b1
splicing factor 3b, subunit 1
MGI:1932339
Synonyms
2810001M05Rik, Prp10, SAP155, SF3b155, Targ4
Feature Type
protein coding gene
Genetic Map
Chromosome 1
27.98 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr1:54985169-55027481 bp, - strand
From VEGA annotation of GRCm38

  42313 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:6696  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: splicing factor 3B subunit 1 (SF3b155)
Gene Tree: Sf3b1

Human
homologs
Human Homolog SF3B1, splicing factor 3b, subunit 1, 155kDa
NCBI Gene ID 23451
neXtProt AC  NX_O75533
Human Synonyms  Hsh155, MDS, PRP10, PRPF10, SAP155, SF3b155
Human Chr (Location)  2q33.1; chr2:197391974-197435091 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human SF3B1
Mutations,
alleles, and
phenotypes
All mutations/alleles(25) : Gene trapped(22) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null embryos die around the 16- to 32-cell stage. Heterozygous mice exhibit various skeletal transformations.
 
Interactions
Sf3b1 interacts with 328 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (17 annotations)
Process anterior/posterior pattern specification, mRNA processing, ...
Component catalytic step 2 spliceosome, chromatin, ...
Function chromatin binding, poly(A) RNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (22)    Tissues (22)    Images (3)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 20
RT-PCR 2
cDNA source data(365)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(369) cDNA(367) Primer pair(2)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000046964 (Evidence)
Ensembl Gene ModelENSMUSG00000025982 (Evidence)
Entrez Gene81898 (Evidence)
UniGene279736
DFCITC1573227, TC1604099, TC1773468
DoTSDT.97340486, DT.94122989, DT.101293042
NIA Mouse Gene IndexU021335
Consensus CDS ProjectCCDS35567.1
International Mouse Knockout Project StatusSf3b1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000046964 VEGA Gene Model | MGI Sequence Detail 42313 C57BL/6J ±  kb
transcript OTTMUST00000121704 VEGA | MGI Sequence Detail 6195 Not Applicable 
polypeptide OTTMUSP00000066983 VEGA | MGI Sequence Detail 1304 Not Applicable 

For the selected sequences
All sequences(72) RefSeq(9) UniProt(16)
Polymorphisms
PCR(2) : SNPs within 2kb(240 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR011989 Armadillo-like helical
InterPro IPR016024 Armadillo-type fold
InterPro IPR015016 Splicing factor 3B subunit 1
Protein Ontology PR:000014734 splicing factor 3B subunit 1
References
(Earliest) J:26127 Babalola GO, et al., Modulation of gene expression in the preimplantation mouse embryo by TGF-alpha and TGF-beta. Mol Reprod Dev. 1995 Jun;41(2):133-9
(Latest) J:213448 Matsunawa M, et al., Haploinsufficiency of Sf3b1 leads to compromised stem cell function but not to myelodysplasia. Leukemia. 2014 Sep;28(9):1844-50
All references(41)
Other
accession IDs
MGI:1100839, MGI:1923833, MGI:2138089

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory