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Sf3b1
Gene Detail
Symbol

Name
ID
Sf3b1
splicing factor 3b, subunit 1
MGI:1932339
Synonyms
2810001M05Rik, Prp10, SAP155, SF3b155, Targ4
Feature Type
protein coding gene
Genetic Map
Chromosome 1
27.98 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr1:54985169-55027481 bp, - strand
From VEGA annotation of GRCm38

  42313 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:6696  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: SF3B1
Protein SuperFamily: splicing factor 3B subunit 1 (SF3b155)
Gene Tree: Sf3b1

Human
homologs
SF3B1, splicing factor 3b, subunit 1, 155kDa
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 23451
neXtProt AC: NX_O75533

Human Synonyms: Hsh155, MDS, PRP10, PRPF10, SAP155, SF3b155

Human Chr (Location): 2q33.1; chr2:197391974-197435091 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human SF3B1

Mutations,
alleles, and
phenotypes
All mutations/alleles(25) : Gene trapped(22) Targeted(3)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygous null embryos die around the 16- to 32-cell stage. Heterozygous mice exhibit various skeletal transformations.
 
Interactions
Sf3b1 interacts with 328 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (27 annotations)
Process anterior/posterior pattern specification, blastocyst formation, ...
Component catalytic step 2 spliceosome, chromatin, ...
Function chromatin binding, mRNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (29)    Tissues (29)    Images (3)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 20
RT-PCR 9
cDNA source data(365)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase sf3b1 ; ZFIN sf3b1    NEW 
Molecular
reagents
All nucleic(370) cDNA(367) Primer pair(3)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000046964 (Evidence)
Ensembl Gene Model ENSMUSG00000025982 (Evidence)
Entrez Gene 81898 (Evidence)
UniGene 279736
DFCI TC1573227, TC1604099, TC1773468
DoTS DT.101293042, DT.94122989, DT.97340486
NIA Mouse Gene Index U021335
Consensus CDS Project CCDS35567.1
International Mouse Phenotyping Consortium Status Sf3b1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000046964 VEGA Gene Model | MGI Sequence Detail 42313 C57BL/6J ±  kb
transcript OTTMUST00000121704 VEGA | MGI Sequence Detail 6195 Not Applicable 
polypeptide OTTMUSP00000066983 VEGA | MGI Sequence Detail 1304 Not Applicable 

For the selected sequences
All sequences(69) RefSeq(5) UniProt(9)
Polymorphisms
PCR(2) : SNPs within 2kb(240 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR011989 Armadillo-like helical
InterPro IPR016024 Armadillo-type fold
InterPro IPR015016 Splicing factor 3B subunit 1
Protein Ontology PR:000014734 splicing factor 3B subunit 1
References
(Earliest) J:26127 Babalola GO, et al., Modulation of gene expression in the preimplantation mouse embryo by TGF-alpha and TGF-beta. Mol Reprod Dev. 1995 Jun;41(2):133-9
(Latest) J:215371 Maserati M, et al., Identification of four genes required for mammalian blastocyst formation. Zygote. 2014 Aug;22(3):331-9
All references(43)
Other
accession IDs
MGI:1100839, MGI:1923833, MGI:2138089

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory