About   Help   FAQ
Sf3b1
Gene Detail
 Symbol
Name
ID
Sf3b1
splicing factor 3b, subunit 1
MGI:1932339
Synonyms 2810001M05Rik, Prp10, SAP155, SF3b155, Targ4
Feature Type protein coding gene
Genetic Map
Chromosome 1
27.98 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr1:54985169-55027478 bp, - strand
From NCBI annotation of GRCm38

  42310 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:6696  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: splicing factor 3B subunit 1 (SF3b155)
Gene Tree: Sf3b1

Human
homologs
Human Homolog SF3B1, splicing factor 3b, subunit 1, 155kDa
NCBI Gene ID 23451
neXtProt AC  NX_O75533
Human Synonyms  Hsh155, MDS, PRP10, PRPF10, SAP155, SF3b155
Human Chr (Location)  2q33.1; chr2:197391974-197435091 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human SF3B1
Alleles
and
phenotypes
All alleles(25) : Targeted(3) Gene trapped(22)
 
Homozygous null embryos die around the 16- to 32-cell stage. Heterozygous mice exhibit various skeletal transformations.
 
Gene Ontology
(GO)
classifications
All GO classifications: (14 annotations)
Process anterior/posterior pattern specification, mRNA processing, ...
Component catalytic step 2 spliceosome, intracellular membrane-bounded organelle, ...
Function chromatin binding, poly(A) RNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (22)    Tissues (22)    Images (3)
Theiler Stages: 21, 28
Assay TypeResults
RNA in situ 20
RT-PCR 2
cDNA source data(365)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(369) cDNA(367) Primer pair(2)
Microarray probesets(5)
Other database
links
Ensembl Gene ModelENSMUSG00000025982 (Evidence)
Entrez Gene81898 (Evidence)
UniGene279736
DFCITC1573227, TC1604099, TC1773468
DoTSDT.101293042, DT.94122989, DT.97340486
NIA Mouse Gene IndexU021335
Consensus CDS ProjectCCDS35567.1
International Mouse Knockout Project StatusSf3b1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 81898 NCBI Gene Model | MGI Sequence Detail 42310 C57BL/6J ±  kb
transcript NM_031179 RefSeq | MGI Sequence Detail 6192 C57BL/6 
polypeptide Q99NB9 UniProt | EBI | MGI Sequence Detail 1304 Not Applicable 

For the selected sequences
All sequences(54) RefSeq(9) UniProt(9)
Polymorphisms PCR(2) : SNPs within 2kb(240 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR011989 Armadillo-like helical
InterPro IPR016024 Armadillo-type fold
InterPro IPR015016 Splicing factor 3B subunit 1
Protein Ontology PR:000014734 splicing factor 3B subunit 1
Graphical View of Protein Domain Structure
References (Earliest) J:26127 Babalola GO, et al., Modulation of gene expression in the preimplantation mouse embryo by TGF-alpha and TGF-beta. Mol Reprod Dev. 1995 Jun;41(2):133-9
(Latest) J:191676 Manceau V, et al., The protein kinase KIS impacts gene expression during development and fear conditioning in adult mice. PLoS One. 2012;7(8):e43946
All references(38)
Other
accession IDs
MGI:1100839, MGI:1923833, MGI:2138089

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
04/08/2014
MGI 5.17
The Jackson Laboratory