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Irx6
Gene Detail
Symbol

Name
ID
Irx6
Iroquois related homeobox 6 (Drosophila)
MGI:1927642
Feature Type
protein coding gene
Genetic Map
Chromosome 8
44.99 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr8:92674288-92680956 bp, + strand
From VEGA annotation of GRCm38

  6669 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:41481  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: IRX6
Gene Tree: Irx6

Human
homologs
IRX6, iroquois homeobox 6
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 79190
neXtProt AC: NX_P78412

Human Synonyms: IRX-3, IRX7, IRXB3

Human Chr (Location): 16q12.2; chr16:55323962-55330760 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Targeted(8)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null mutation display abnormalities in retinal bipolar cell subtype identity and reduced electroretinography a and b wave amplitudes.
 
Interactions
Irx6 interacts with 150 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (6 annotations)
Process regulation of transcription, DNA-templated
Component nucleus
Function DNA binding, sequence-specific DNA binding
External Resources: FuncBase
Expression
Literature Summary: (16 records)
Data Summary: Results (88)    Tissues (83)    Images (17)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 82
RT-PCR 6
cDNA source data(9)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: ZFIN irx6a    NEW 
Molecular
reagents
All nucleic(12) Genomic(1) cDNA(9) Primer pair(1) Other(1)
Microarray probesets(2)
Other database
links
VEGA Gene Model OTTMUSG00000035969 (Evidence)
Ensembl Gene Model ENSMUSG00000031738 (Evidence)
Entrez Gene 64379 (Evidence)
UniGene 137247
DFCI TC1588394
DoTS DT.94325685
NIA Mouse Gene Index U009638
Consensus CDS Project CCDS40428.1
International Mouse Phenotyping Consortium Status Irx6
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000035969 VEGA Gene Model | MGI Sequence Detail 6669 C57BL/6J ±  kb
transcript OTTMUST00000092296 VEGA | MGI Sequence Detail 3370 Not Applicable 
polypeptide OTTMUSP00000050970 VEGA | MGI Sequence Detail 439 Not Applicable 

For the selected sequences
All sequences(29) RefSeq(4) UniProt(2)
Polymorphisms
SNPs within 2kb(75 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017970 Homeobox, conserved site
InterPro IPR008422 Homeobox KN domain
InterPro IPR001356 Homeodomain
InterPro IPR009057 Homeodomain-like
InterPro IPR003893 Iroquois-class homeodomain protein
Protein Ontology PR:000029562 iroquois-class homeodomain protein IRX-6
References
(Earliest) J:65170 Peters T, et al., Organization of mouse iroquois homeobox genes in two clusters suggests a conserved regulation and function in vertebrate development. Genome Res. 2000 Oct;10(10):1453-62
(Latest) J:216471 Sapkota D, et al., Onecut1 and Onecut2 redundantly regulate early retinal cell fates during development. Proc Natl Acad Sci U S A. 2014 Sep 30;111(39):E4086-95
All references(43)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory