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Irx6
Gene Detail
 Symbol
Name
ID
Irx6
Iroquois related homeobox 6 (Drosophila)
MGI:1927642
Feature Type protein coding gene
Genetic Map
Chromosome 8
44.99 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr8:92674288-92680956 bp, + strand
From VEGA annotation of GRCm38

  6669 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:41481  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

Gene Tree: Irx6

Human
homologs
Human Homolog IRX6, iroquois homeobox 6
NCBI Gene ID 79190
neXtProt AC  NX_P78412
Human Synonyms  IRX-3, IRX7, IRXB3
Human Chr (Location)  16q12.2; chr16:55324494-55330760 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Targeted(8)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null mutation display abnormalities in retinal bipolar cell subtype identity and reduced electroretinography a and b wave amplitudes.
 
Interactions
Irx6 interacts with 151 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (6 annotations)
Process regulation of transcription, DNA-templated
Component nucleus
Function DNA binding, sequence-specific DNA binding
External Resources: FuncBase
Expression
Literature Summary: (15 records)
Data Summary: Results (88)    Tissues (83)    Images (17)
Theiler Stages: 15, 17, 19, 20, 21, 23, 27, 28
Assay TypeResults
RNA in situ 82
RT-PCR 6
cDNA source data(9)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(12) Genomic(1) cDNA(9) Primer pair(1) Other(1)
Microarray probesets(2)
Other database
links
VEGA Gene ModelOTTMUSG00000035969 (Evidence)
Ensembl Gene ModelENSMUSG00000031738 (Evidence)
Entrez Gene64379 (Evidence)
UniGene137247
DFCITC1588394
DoTSDT.94325685
NIA Mouse Gene IndexU009638
Consensus CDS ProjectCCDS40428.1
International Mouse Knockout Project StatusIrx6
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000035969 VEGA Gene Model | MGI Sequence Detail 6669 C57BL/6J ±  kb
transcript OTTMUST00000092296 VEGA | MGI Sequence Detail 3370 Not Applicable 
polypeptide OTTMUSP00000050970 VEGA | MGI Sequence Detail 439 Not Applicable 

For the selected sequences
All sequences(29) RefSeq(4) UniProt(2)
Polymorphisms SNPs within 2kb(75 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017970 Homeobox, conserved site
InterPro IPR008422 Homeobox KN domain
InterPro IPR001356 Homeodomain
InterPro IPR009057 Homeodomain-like
InterPro IPR003893 Iroquois-class homeodomain protein
Protein Ontology PR:000029562 iroquois-class homeodomain protein IRX-6
References (Earliest) J:65170 Peters T, et al., Organization of mouse iroquois homeobox genes in two clusters suggests a conserved regulation and function in vertebrate development. Genome Res. 2000 Oct;10(10):1453-62
(Latest) J:189955 Star EN, et al., Regulation of retinal interneuron subtype identity by the Iroquois homeobox gene Irx6. Development. 2012 Dec;139(24):4644-55
All references(43)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory