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Irx6 Gene Detail
Summary
  • Symbol
    Irx6
  • Name
    Iroquois related homeobox 6 (Drosophila)
  • Feature Type
    protein coding gene
  • IDs
    MGI:1927642
    NCBI Gene: 64379
  • Gene Overview
    MyGene.info: IRX6
Location & Maps
more
  • Sequence Map
    Chr8:92674288-92680956 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      6669 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    IRX6, iroquois homeobox 6
  • Vertebrate Orthologs
    9
  • Human Ortholog
    IRX6, iroquois homeobox 6
    Orthology source: HGNC, HomoloGene
  • Synonyms
    IRX-3, IRX7, IRXB3
  • Links
    NCBI Gene ID: 79190
    neXtProt AC: NX_P78412

  • Chr Location
    16q12.2; chr16:55323962-55330760 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 41481
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: IRX6
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    1 phenotype from multigenic genotypes
    4 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
Mice homozygous for a null mutation display abnormalities in retinal bipolar cell subtype identity and reduced electroretinography a and b wave amplitudes.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000035969 VEGA Gene Model | MGI Sequence Detail 6669 C57BL/6J ±  kb
transcript OTTMUST00000092296 VEGA | MGI Sequence Detail 3370 Not Applicable  
polypeptide OTTMUSP00000050970 VEGA | MGI Sequence Detail 439 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    73 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
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  • All nucleic 12
    Genomic 1
    cDNA 9
    Primer pair 1
    Other 1

    Microarray probesets 2
References
more
  • Summaries
    All 41
    Developmental Gene Expression 17
    Gene Ontology 3
    Phenotypes 4
  • Earliest
    J:65170 Peters T, et al., Organization of mouse iroquois homeobox genes in two clusters suggests a conserved regulation and function in vertebrate development. Genome Res. 2000 Oct;10(10):1453-62
  • Latest
    J:226218 Peyrard-Janvid M, et al., Dominant mutations in GRHL3 cause Van der Woude Syndrome and disrupt oral periderm development. Am J Hum Genet. 2014 Jan 2;94(1):23-32

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory