Trpv4
Gene Detail

Symbol Name ID

Trpv4 transient receptor potential cation channel, subfamily V, member 4 MGI:1926945

Synonyms

0610033B08Rik, OTRPC4, Trp12, VRL-2, VROAC, VR-OAC

Feature Type

protein coding gene

Genetic Map

Chromosome 5

55.99 cM, cytoband F
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr5:114622152-114658421 bp, - strand From VEGA annotation of GRCm38   36270 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:11003  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: transient receptor potential cation channel, subfamily V
Gene Tree: Trpv4

Human homologs

Human Homolog		TRPV4, transient receptor potential cation channel, subfamily V, member 4
NCBI Gene ID		59341
neXtProt AC		NX_Q9HBA0
Human Synonyms		CMT2C, HMSN2C, OTRPC4, SMAL, SPSMA, SSQTL1, TRP12, VRL2, VROAC
Human Chr (Location)		12q24.1; chr12:110220892-110271212 (-)  GRCh37.p10
Disease Associations		(10) Diseases Associated with Human TRPV4

Alleles and phenotypes

All alleles(6) : Targeted(5) Gene trapped(1)
 

Null mutations of this locus have been associated with reduced responsiveness to pressure sensations and abnormal osmotic regulation.

 
Human Diseases Modeled Using Mouse Trpv4 (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (66 annotations)

Process	actin cytoskeleton reorganization, actin filament organization, ...
Component	adherens junction, cell junction, ...
Function	actin binding, actin filament binding, ...

External Resources: FuncBase

Expression

Literature Summary: (5 records)
Data Summary: Results (246)    Tissues (67)    Images (33)
Theiler Stages: 19, 23, 25, 26, 28

Assay Type	Results
RNA in situ	239
RT-PCR	7

cDNA source data(26)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(29) cDNA(28) Primer pair(1)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000014501 (Evidence)
Ensembl Gene Model	ENSMUSG00000014158 (Evidence)
Entrez Gene	63873 (Evidence)
UniGene	266450
DFCI	TC1578201
DoTS	DT.101221724, DT.484715
NIA Mouse Gene Index	U026603
Consensus CDS Project	CCDS19568.1
International Mouse Knockout Project Status	Trpv4

Sequences

Length	Strain/Species
genomic	OTTMUSG00000014501	VEGA Gene Model | MGI Sequence Detail	36270	C57BL/6J
transcript	OTTMUST00000034430	VEGA | MGI Sequence Detail	3228	Not Applicable
polypeptide	OTTMUSP00000015421	VEGA | MGI Sequence Detail	871	Not Applicable

All sequences(46) RefSeq(2) UniProt(5)

Polymorphisms

SNPs(82 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR002110	Ankyrin repeat
InterPro	IPR020683	Ankyrin repeat-containing domain
InterPro	IPR005821	Ion transport domain
InterPro	IPR004729	Transient receptor potential channel
InterPro	IPR024862	Transient receptor potential channel, vanilloid
InterPro	IPR008347	Transient receptor potential channel, vanilloid 1-4
InterPro	IPR008348	Transient receptor potential channel, vanilloid 4
Protein Ontology	PR:000001068	transient receptor potential cation channel TRPV4

References

(Earliest) J:65451 Strotmann R, et al., OTRPC4, a nonselective cation channel that confers sensitivity to extracellular osmolarity. Nat Cell Biol. 2000 Oct;2(10):695-702
(Latest) J:188264 Ye L, et al., TRPV4 Is a Regulator of Adipose Oxidative Metabolism, Inflammation, and Energy Homeostasis. Cell. 2012 Sep 28;151(1):96-110
All references(98)

Other accession IDs

MGI:1918936