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Trpv4 Gene Detail
Summary
  • Symbol
    Trpv4
  • Name
    transient receptor potential cation channel, subfamily V, member 4
  • Synonyms
    0610033B08Rik, OTRPC4, Trp12, VRL-2, VR-OAC, VROAC
  • Feature Type
    protein coding gene
  • IDs
    MGI:1926945
    NCBI Gene: 63873
  • Alliance
    genome feature page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:114760213-114796482 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 55.99 cM, cytoband F
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1195 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1926945
 protein coding gene Chr5:114760213-114796497 (-)
129S1/SvImJ ENSMUSG00200021577
 protein coding gene Chr5:108501688-108537896 (-)
A/J ENSMUSG00195034478
 protein coding gene Chr5:108014295-108050501 (-)
AKR/J ENSMUSG00220042558
 protein coding gene Chr5:107531011-107567221 (-)
BALB/cJ ENSMUSG00180046014
 protein coding gene Chr5:108152339-108188550 (-)
C3H/HeJ ENSMUSG00175043323
 protein coding gene Chr5:110140484-110176719 (-)
C57BL/6NJ ENSMUSG00215009961
 protein coding gene Chr5:108160813-108197080 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027599
 protein coding gene Chr5:107585949-107622376 (-)
CAST/EiJ ENSTCUG00005022815
 protein coding gene Chr5:107341895-107377977 (-)
CBA/J ENSMUSG00210035333
 protein coding gene Chr5:108892551-108928786 (-)
DBA/2J ENSMUSG00185042542
 protein coding gene Chr5:111943336-111979598 (-)
FVB/NJ ENSMUSG00205031887
 protein coding gene Chr5:107790772-107827013 (-)
JF1/MsJ ENSUMUG00000024788
 protein coding gene Chr5:114784972-114820997 (-)
LP/J ENSMUSG00230047035
 protein coding gene Chr5:116039859-116076069 (-)
NOD/ShiLtJ ENSMUSG00190028339
 protein coding gene Chr5:107828808-107865081 (-)
NZO/HlLtJ ENSMUSG00225013772
 protein coding gene Chr5:123692782-123729048 (-)
PWK/PhJ ENSLUMG00010038026
 protein coding gene Chr5:106688777-106724882 (-)
SPRET/EiJ ENSMSPG00010042781
 protein coding gene Chr5:109969471-110005120 (-)
WSB/EiJ ENSIUOG00005040190
 protein coding gene Chr5:110532711-110568903 (-)



Homology
more
  • Human Ortholog
    TRPV4, transient receptor potential cation channel subfamily V member 4
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TRPV4, transient receptor potential cation channel subfamily V member 4
  • Synonyms
    BCYM3, CMT2C, HMSN2C, OTRPC4, SMAL, SPSMA, SSQTL1, TRP12, VRL2, VROAC
  • Links
    NCBI Gene ID: 59341
    UniProt: Q9HBA0

  • Chr Location
    12q24.11; chr12:109783087-109833406 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Trpv4 mouse models; 8 with human TRPV4 associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    64 phenotypes from 8 alleles in 8 genetic backgrounds
    2 images
    251 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a null allele show abnormal touch/nociception and late-onset hearing loss. Homozygotes for a different null allele show impaired bladder voiding, abnormalities in touch/nociception, osmotic regulation and vasodilation, ocular hypertension but no hearing or vestibular deficits.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    172
  • GO References
    25
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1040
  • Tissues
    138
  • cDNA Data
    28
  • Literature Summary
    19
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000014158 Ensembl Gene Model | MGI Sequence Detail 36270 C57BL/6J ±  kb
    transcript ENSMUST00000071968 Ensembl | MGI Sequence Detail 3228 Not Applicable  
    polypeptide ENSMUSP00000071859 Ensembl | MGI Sequence Detail 871 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 39
      cDNA 30
      Primer pair 6
      Other 3
      Antibodies 4

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:1918936
    References
    more
    • Summaries
      All 379
      Developmental Gene Expression 19
      Diseases 1
      Gene Ontology 25
      Phenotypes 251
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:390380 Girard BM, et al., The Role of TRPV4 in Repeated Variate Stress-Induced Increases in Voiding Frequency and Somatic Sensitivity in Male and Female Mice. J Mol Neurosci. 2026 May 28;76(2)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory