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Trpv4
Gene Detail
Symbol

Name
ID
Trpv4
transient receptor potential cation channel, subfamily V, member 4
MGI:1926945
Synonyms
0610033B08Rik, OTRPC4, Trp12, VRL-2, VROAC, VR-OAC
Feature Type
protein coding gene
Genetic Map
Chromosome 5
55.99 cM, cytoband F
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr5:114622152-114658421 bp, - strand
From VEGA annotation of GRCm38

  36270 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:11003  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: TRPV4
Protein SuperFamily: transient receptor potential cation channel, subfamily V
Gene Tree: Trpv4

Human
homologs
TRPV4, transient receptor potential cation channel, subfamily V, member 4
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 59341
neXtProt AC: NX_Q9HBA0

Human Synonyms: BCYM3, CMT2C, HMSN2C, OTRPC4, SMAL, SPSMA, SSQTL1, TRP12, VRL2, VROAC

Human Chr (Location): 12q24.1; chr12:109783087-109833407 (-)  GRCh38.p2

Disease Associations: (9) Diseases Associated with Human TRPV4

Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Gene trapped(1) Targeted(6)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Null mutations of this locus have been associated with reduced responsiveness to pressure sensations and abnormal osmotic regulation.
 
Human Diseases Modeled in Mice Using Trpv4 (1)    Mutations Annotated to Human Diseases (1)   
Interactions
Trpv4 interacts with 67 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (76 annotations)
Process actin cytoskeleton reorganization, actin filament organization, ...
Component adherens junction, cell, ...
Function actin binding, actin filament binding, ...
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (246)    Tissues (68)    Images (33)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 239
RT-PCR 7
cDNA source data(27)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: GEISHA TRPV4 ; Xenbase trpv4 ; ZFIN trpv4    NEW 
Molecular
reagents
All nucleic(30) cDNA(29) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000014501 (Evidence)
Ensembl Gene Model ENSMUSG00000014158 (Evidence)
Entrez Gene 63873 (Evidence)
UniGene 266450
DFCI TC1578201
DoTS DT.101221724, DT.484715
NIA Mouse Gene Index U026603
Consensus CDS Project CCDS19568.1
International Mouse Phenotyping Consortium Status Trpv4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000014501 VEGA Gene Model | MGI Sequence Detail 36270 C57BL/6J ±  kb
transcript OTTMUST00000034430 VEGA | MGI Sequence Detail 3228 Not Applicable 
polypeptide OTTMUSP00000015421 VEGA | MGI Sequence Detail 871 Not Applicable 

For the selected sequences
All sequences(52) RefSeq(6) UniProt(6)
Polymorphisms
SNPs within 2kb(145 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002110 Ankyrin repeat
InterPro IPR020683 Ankyrin repeat-containing domain
InterPro IPR005821 Ion transport domain
InterPro IPR004729 Transient receptor potential channel
InterPro IPR008347 Transient receptor potential channel, vanilloid 1-4
InterPro IPR008348 Transient receptor potential channel, vanilloid 4
Protein Ontology PR:000001068 transient receptor potential cation channel TRPV4
References
(Earliest) J:65451 Strotmann R, et al., OTRPC4, a nonselective cation channel that confers sensitivity to extracellular osmolarity. Nat Cell Biol. 2000 Oct;2(10):695-702
(Latest) J:220377 Shibasaki K, et al., Hippocampal neuronal maturation triggers post-synaptic clustering of brain temperature-sensor TRPV4. Biochem Biophys Res Commun. 2015 Feb 27;458(1):168-73
All references(114)
Disease annotation references (1)
Other
accession IDs
MGI:1918936

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/20/2015
MGI 5.22
The Jackson Laboratory