Trpv4^tm1Msz
Targeted Allele Detail

Summary

• Symbol: Trpv4^tm1Msz
• Name: transient receptor potential cation channel, subfamily V, member 4; targeted mutation 1, Makoto Suzuki
• MGI ID: MGI:2667379
• Synonyms: Trpv4^-, TRPV4KO
• Gene: Trpv4 Location: Chr5:114760213-114796482 bp, - strand Genetic Position: Chr5, 55.99 cM, cytoband F
• Alliance: Trpv4^tm1Msz page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:84093
• Parent Cell Line: RW-4 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A neomycin resistance gene was inserted into exon 4 which encodes the ankyrin-repeat domain. Transcripts were undetectable by RT-PCR and Northern blot in trigeminal root and dorsal root ganglia of homozygous animals. Immunohistochemical staining of the dorsal root ganglion confirmed the success of gene disruption. (J:84093)

Disease models

Expression

In Mice Carrying this Mutation:

5 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Trpv4 Mutation: 57 strains or lines available

References

• Original: J:84093 Suzuki M, et al., Impaired pressure sensation in mice lacking TRPV4. J Biol Chem. 2003 Jun 20;278(25):22664-8
• All: 88 reference(s)