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Phenotypes Associated with This Genotype
Genotype
MGI:2669172
Allelic
Composition
Trpv4tm1Msz/Trpv4tm1Msz
Genetic
Background
involves: 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trpv4tm1Msz mutation (1 available); any Trpv4 mutation (57 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• ability to detect heat not altered
• significantly reduced response to pressure on the tail
• threshold response of the femoral nerve to pressure was increased
• absence of pressure sensitive C-fiber
• reduced frequency of writhing for 10 minutes after application of acetic acid to the abdomen
• avoidance of noxious odors unaltered

hearing/vestibular/ear
• at 24 weeks, homozygotes display significantly elevated ABR thresholds, with no detectable changes in DPOAE amplitudes relative to wild-type mice
• however, at 24 weeks, the stria vascularis, cochlear IHCs and OHCs, and spiral ganglion cells are morphologically normal with no significant changes in cell density
• no significant differences in ABR thresholds or DPOAE amplitudes are noted at 8 weeks of age
• at 1 week after acoustic overexposure (128 dB SPL), homozygotes exhibit a significantly greater ABR threshold shift, albeit with no differences in IHC and OHC loss relative to wild-type mice
• homozygotes display delayed-onset hearing loss, as assessed by ABR measurements at 24 weeks

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
autosomal dominant nonsyndromic deafness 25 DOID:0110555 OMIM:605583
J:104851


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory