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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
Trpv4
transient receptor potential cation channel, subfamily V, member 4
MGI:1926945
52 phenotypes from 6 alleles in 7 genetic backgrounds
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Allelic Composition
Genetic Background
Annotated Term Reference
Tg(Tyr,Col2a1-Trpv4*R594H)#Dhco/0
involves: FVB/N
abnormal bone mineralization J:233234
abnormal carpal bone morphology J:233234
abnormal epiphyseal plate morphology J:233234
abnormal fluid regulation J:233234
abnormal long bone diaphysis morphology J:233234
abnormal long bone epiphyseal plate proliferative zone J:233234
abnormal lumbar vertebrae morphology J:233234
abnormal metacarpal bone morphology J:233234
abnormal phalanx morphology J:233234
abnormal skeleton morphology J:233234
decreased bone mineralization J:233234
decreased fetal size J:233234
decreased length of long bones J:233234
decreased width of hypertrophic chondrocyte zone J:233234
failure of endochondral bone ossification J:233234
fused carpal bones J:233234
midface hypoplasia J:233234
perinatal lethality, complete penetrance J:233234
short limbs J:233234
short snout J:233234
short tail J:233234
thickened long bone epiphysis J:233234
Trpv4tm1.1Ldtk/Trpv4tm1.1Ldtk
Tg(KRT14-cre/ERT)20Efu/0
involves: C57BL/6 * CD-1 * SJL
abnormal mechanical nociception J:200749
abnormal skin physiology J:200749
normal behavior/neurological phenotype J:200749
increased thermal nociceptive threshold J:200749
Trpv4tm1c(KOMP)Wtsi/Trpv4tm1c(KOMP)Wtsi
Tg(GFAP-cre)25Mes/0
involves: C57BL/6J * C57BL/6N * FVB/N
abnormal response to injury J:266383
Trpv4tm1d(KOMP)Wtsi/Trpv4tm1d(KOMP)Wtsi
involves: C57BL/6J * C57BL/6N
abnormal response to injury J:266383
Trpv4tm1Msz/Trpv4tm1Msz
involves: 129X1/SvJ * C57BL/6
abnormal response to tactile stimuli J:84093
abnormal sensory capabilities/reflexes/nociception J:84093
impaired hearing J:104851
increased chemical nociceptive threshold J:84093
increased or absent threshold for auditory brainstem response J:104851
increased susceptibility to noise-induced hearing loss J:104851
Trpv4tm1Rck/Trpv4tm1Rck
involves: C57BL/6
abnormal neuron physiology J:107380
abnormal nociception after inflammation J:107380
abnormal pain threshold J:107380
abnormal urinary bladder physiology J:127385
normal behavior/neurological phenotype J:127385
urinary incontinence J:127385
Trpv4tm1Rck/Trpv4tm1Rck
Not Specified
abnormal drinking behavior J:86560
abnormal fluid regulation J:86560
abnormal keratinocyte physiology J:200749
abnormal mechanical nociception J:86560, J:200749
abnormal respiratory system physiology J:126500
abnormal trabecular meshwork morphology J:216400
abnormal vascular endothelial cell physiology J:129365
abnormal vasodilation J:129365
normal behavior/neurological phenotype J:86560, J:200749
decreased blood osmolality J:86560
decreased circulating antidiuretic hormone level J:86560
decreased fluid intake J:86560
decreased susceptibility to injury J:126500
normal hearing/vestibular/ear phenotype J:86560
normal homeostasis/metabolism phenotype J:86560
increased blood osmolality J:86560
increased thermal nociceptive threshold J:200749
ocular hypertension J:216400

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/16/2024
MGI 6.23
The Jackson Laboratory