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Orai1 Gene Detail
Summary
  • Symbol
    Orai1
  • Name
    ORAI calcium release-activated calcium modulator 1
  • Synonyms
    D730049H07Rik, Tmem142a
  • Feature Type
    protein coding gene
  • IDs
    MGI:1925542
    NCBI Gene: 109305
  • Gene Overview
    MyGene.info: ORAI1
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:123015074-123030452 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 62.72 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    75 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1925542
protein coding gene Chr5:123015074-123030456 (.)
129S1/SvImJ MGP_129S1SvImJ_G0030061
protein coding gene Chr5:126693879-126709270 (+)
A/J MGP_AJ_G0030026
protein coding gene Chr5:121435895-121451232 (+)
AKR/J MGP_AKRJ_G0029962
protein coding gene Chr5:125351670-125366979 (+)
BALB/cJ MGP_BALBcJ_G0030037
protein coding gene Chr5:122781873-122797727 (+)
C3H/HeJ MGP_C3HHeJ_G0029754
protein coding gene Chr5:125974594-125993649 (+)
C57BL/6NJ MGP_C57BL6NJ_G0030490
protein coding gene Chr5:131579004-131595806 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027716
protein coding gene Chr5:116035444-116049311 (+)
CAST/EiJ MGP_CASTEiJ_G0029163
protein coding gene Chr5:125072211-125089679 (+)
CBA/J MGP_CBAJ_G0029724
protein coding gene Chr5:136733117-136755283 (+)
DBA/2J MGP_DBA2J_G0029874
protein coding gene Chr5:121493944-121509459 (+)
FVB/NJ MGP_FVBNJ_G0029830
protein coding gene Chr5:120494166-120509716 (+)
LP/J MGP_LPJ_G0029963
protein coding gene Chr5:127229018-127244294 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0029861
protein coding gene Chr5:140411699-140427327 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0030531
protein coding gene Chr5:124953561-124971070 (+)
PWK/PhJ MGP_PWKPhJ_G0028877
protein coding gene Chr5:120280315-120295999 (+)
SPRET/EiJ MGP_SPRETEiJ_G0028714
protein coding gene Chr5:122646119-122661631 (+)
WSB/EiJ MGP_WSBEiJ_G0029238
protein coding gene Chr5:125620709-125636595 (+)



Homology
more
  • Human Ortholog
    ORAI1, ORAI calcium release-activated calcium modulator 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ORAI1, ORAI calcium release-activated calcium modulator 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CRACM1, IMD9, ORAT1, TAM2, TMEM142A
  • Links
    NCBI Gene ID: 84876
    neXtProt AC: NX_Q96D31
    UniProt: Q96D31

  • Chr Location
    12q24.31; chr12:121626550-121642040 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 13117
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: ORAI1
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with human ORAI1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    29 phenotypes from 4 alleles in 6 genetic backgrounds
    10 phenotypes from multigenic genotypes
    40 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit small body size and defective mast cell degranulation, cytokine secretion and passive anaphalaxis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 109305 NCBI Gene Model | MGI Sequence Detail 15379 C57BL/6J ±  kb
    transcript NM_175423 RefSeq | MGI Sequence Detail 1871 C57BL/6  
    polypeptide Q8BWG9 UniProt | EBI | MGI Sequence Detail 304 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • InterPro Domains
      IPR012446 Calcium release-activated calcium channel protein
    Molecular
    Reagents
    less
    • All nucleic 34
      cDNA 33
      Primer pair 1

      Microarray probesets 3
    References
    more
    • Summaries
      All 90
      Developmental Gene Expression 2
      Gene Ontology 8
      Phenotypes 40
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:258236 El Hachmane MF, et al., Extracellular ATP activates store-operated Ca(2+) entry in white adipocytes: functional evidence for STIM1 and ORAI1. Biochem J. 2018 Feb 14;475(3):691-704

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/13/2018
    MGI 6.13
    The Jackson Laboratory