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Orai1
Gene Detail
Symbol

Name
ID
Orai1
ORAI calcium release-activated calcium modulator 1
MGI:1925542
Synonyms
D730049H07Rik, Tmem142a
Feature Type
protein coding gene
Genetic Map
Chromosome 5
62.72 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr5:123015074-123030450 bp, + strand
From VEGA annotation of GRCm38

  15377 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:13117  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Orai1

Human
homologs
Human Homolog ORAI1, ORAI calcium release-activated calcium modulator 1
NCBI Gene ID 84876
neXtProt AC  NX_Q96D31
Human Synonyms  CRACM1, IMD9, ORAT1, TAM2, TMEM142A
Human Chr (Location)  12q24.31; chr12:121626550-121642040 (+)  GRCh38
Disease Associations  (2) Diseases Associated with Human ORAI1
Mutations,
alleles, and
phenotypes
All mutations/alleles(27) : Gene trapped(23) Targeted(4)
 
Mice homozygous for a null allele exhibit small body size and defective mast cell degranulation, cytokine secretion and passive anaphalaxis.
 
Interactions
Orai1 interacts with 98 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (24 annotations)
Process calcium ion transmembrane transport, calcium ion transport, ...
Component growth cone, integral component of membrane, ...
Function calcium channel activity, calmodulin binding, ...
External Resources: FuncBase
Expression
cDNA source data(32)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(32) cDNA(32)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000026744 (Evidence)
Ensembl Gene ModelENSMUSG00000049686 (Evidence)
Entrez Gene109305 (Evidence)
UniGene218582
DFCITC1582313
DoTSDT.495023, DT.101725533
NIA Mouse Gene IndexU006156
Consensus CDS ProjectCCDS39261.1
International Mouse Knockout Project StatusOrai1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000026744 VEGA Gene Model | MGI Sequence Detail 15377 C57BL/6J ±  kb
transcript OTTMUST00000066147 VEGA | MGI Sequence Detail 1869 Not Applicable 
polypeptide OTTMUSP00000033100 VEGA | MGI Sequence Detail 304 Not Applicable 

For the selected sequences
All sequences(32) RefSeq(6) UniProt(3)
Polymorphisms
SNPs within 2kb(75 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR012446 Calcium release-activated calcium channel protein
Protein Ontology PR:000012027 calcium release-activated calcium channel protein 1
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:207167 Kim KD, et al., Calcium signaling via Orai1 is essential for induction of the nuclear orphan receptor pathway to drive Th17 differentiation. J Immunol. 2014 Jan 1;192(1):110-22
All references(56)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/16/2014
MGI 5.20
The Jackson Laboratory