Orai1
Gene Detail

Symbol Name ID

Orai1 ORAI calcium release-activated calcium modulator 1 MGI:1925542

Synonyms

D730049H07Rik, Tmem142a

Feature Type

protein coding gene

Genetic Map

Chromosome 5

62.72 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr5:123015074-123030450 bp, + strand From VEGA annotation of GRCm38   15377 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:13117  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Orai1

Human homologs

Human Homolog		ORAI1, ORAI calcium release-activated calcium modulator 1
NCBI Gene ID		84876
neXtProt AC		NX_Q96D31
Human Synonyms		CRACM1, ORAT1, TMEM142A
Human Chr (Location)		12q24.31; chr12:122064455-122079946 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human ORAI1

Alleles and phenotypes

All alleles(27) : Targeted(4) Gene trapped(23)
 

Mice homozygous for a null allele exhibit small body size and defective mast cell degranulation, cytokine secretion and passive anaphalaxis.

 

Gene Ontology (GO) classifications

All GO classifications: (20 annotations)

Process	calcium ion transmembrane transport, calcium ion transport, ...
Component	growth cone, integral to membrane, ...
Function	calcium channel activity, ion channel activity, ...

External Resources: FuncBase

Expression

cDNA source data(32)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(32) cDNA(32)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000026744 (Evidence)
Ensembl Gene Model	ENSMUSG00000049686 (Evidence)
Entrez Gene	109305 (Evidence)
UniGene	218582
DFCI	TC1582313
DoTS	DT.101725533, DT.495023
NIA Mouse Gene Index	U006156
Consensus CDS Project	CCDS39261.1
International Mouse Knockout Project Status	Orai1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000026744	VEGA Gene Model | MGI Sequence Detail	15377	C57BL/6J
transcript	OTTMUST00000066147	VEGA | MGI Sequence Detail	1869	Not Applicable
polypeptide	OTTMUSP00000033100	VEGA | MGI Sequence Detail	304	Not Applicable

All sequences(27) RefSeq(2) UniProt(2)

Polymorphisms

SNPs(70 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR012446	Calcium release-activated calcium channel protein
Protein Ontology	PR:000012027	calcium release-activated calcium channel protein 1

References

(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:190864 Dixit N, et al., Leukocyte Function Antigen-1, Kindlin-3, and Calcium Flux Orchestrate Neutrophil Recruitment during Inflammation. J Immunol. 2012 Dec 15;189(12):5954-64
All references(49)