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Orai1 Gene Detail
Summary
  • Symbol
    Orai1
  • Name
    ORAI calcium release-activated calcium modulator 1
  • Synonyms
    D730049H07Rik, Tmem142a
  • Feature Type
    protein coding gene
  • IDs
    MGI:1925542
    NCBI Gene: 109305
  • Gene Overview
    MyGene.info: ORAI1
Location & Maps
more
  • Sequence Map
    Chr5:123015074-123030456 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      15383 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 62.72 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    ORAI1, ORAI calcium release-activated calcium modulator 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ORAI1, ORAI calcium release-activated calcium modulator 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CRACM1, IMD9, ORAT1, TAM2, TMEM142A
  • Links
    NCBI Gene ID: 84876
    neXtProt AC: NX_Q96D31

  • Chr Location
    12q24.31; chr12:121626550-121642040 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 13117
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed
  • HCOP
    human homology predictions: ORAI1
  • Gene Tree
Human Diseases
more
  • Diseases
    2 with human ORAI1 associations

Human Disease Mouse Models
       Immunodeficiency 9; IMD9   OMIM: 612782
Myopathy, Tubular Aggregate, 2; TAM2   OMIM: 615883
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    28 phenotypes from 3 alleles in 5 genetic backgrounds
    31 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    32
  • Chemically induced (other)
    1
  • Gene trapped
    23
  • Radiation induced
    1
  • Targeted
    7
  • Genomic Mutations
    2 involving Orai1
Mice homozygous for a null allele exhibit small body size and defective mast cell degranulation, cytokine secretion and passive anaphalaxis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000026744 VEGA Gene Model | MGI Sequence Detail 15383 C57BL/6J ±  kb
transcript OTTMUST00000066147 VEGA | MGI Sequence Detail 1875 Not Applicable  
polypeptide OTTMUSP00000033100 VEGA | MGI Sequence Detail 304 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    75 from dbSNP Build 142
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000012027 calcium release-activated calcium channel protein 1
  • InterPro Domains
    IPR012446 Calcium release-activated calcium channel protein
Molecular
Reagents
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  • All nucleic 32
    cDNA 32

    Microarray probesets 3
References
more
  • Summaries
    All 61
    Developmental Gene Expression 1
    Gene Ontology 7
    Phenotypes 31
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:229767 Sogkas G, et al., Orai1 controls C5a-induced neutrophil recruitment in inflammation. Eur J Immunol. 2015 Jul;45(7):2143-53

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/13/2016
MGI 6.05
The Jackson Laboratory