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Orai1
Gene Detail
Symbol

Name
ID
Orai1
ORAI calcium release-activated calcium modulator 1
MGI:1925542
Synonyms
D730049H07Rik, Tmem142a
Feature Type
protein coding gene
Genetic Map
Chromosome 5
62.72 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr5:123015074-123030456 bp, + strand
From VEGA annotation of GRCm38

  15383 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:13117  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: ORAI1
Gene Tree: Orai1

Human
homologs
ORAI1, ORAI calcium release-activated calcium modulator 1
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 84876
neXtProt AC: NX_Q96D31

Human Synonyms: CRACM1, IMD9, ORAT1, TAM2, TMEM142A

Human Chr (Location): 12q24.31; chr12:121626550-121642040 (+)  GRCh38.p2

Disease Associations: (2) Diseases Associated with Human ORAI1

Mutations,
alleles, and
phenotypes
All mutations/alleles(29) : Gene trapped(23) Targeted(6)
 
Mice homozygous for a null allele exhibit small body size and defective mast cell degranulation, cytokine secretion and passive anaphalaxis.
 
Interactions
Orai1 interacts with 98 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (32 annotations)
Process adaptive immune response, calcium ion import, ...
Component autophagosome, basolateral plasma membrane, ...
Function calcium channel activity, calmodulin binding, ...
External Resources: FuncBase
Expression
cDNA source data(32)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase orai1 ; ZFIN orai1b    NEW 
Molecular
reagents
All nucleic(32) cDNA(32)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000026744 (Evidence)
Ensembl Gene Model ENSMUSG00000049686 (Evidence)
Entrez Gene 109305 (Evidence)
UniGene 218582
DFCI TC1582313
DoTS DT.101725533, DT.495023
NIA Mouse Gene Index U006156
Consensus CDS Project CCDS39261.1
International Mouse Phenotyping Consortium Status Orai1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000026744 VEGA Gene Model | MGI Sequence Detail 15383 C57BL/6J ±  kb
transcript OTTMUST00000066147 VEGA | MGI Sequence Detail 1875 Not Applicable 
polypeptide OTTMUSP00000033100 VEGA | MGI Sequence Detail 304 Not Applicable 

For the selected sequences
All sequences(31) RefSeq(6) UniProt(2)
Polymorphisms
SNPs within 2kb(75 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR012446 Calcium release-activated calcium channel protein
Protein Ontology PR:000012027 calcium release-activated calcium channel protein 1
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:221326 Davis FM, et al., Essential role of Orai1 store-operated calcium channels in lactation. Proc Natl Acad Sci U S A. 2015 May 5;112(18):5827-32
All references(61)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory