Automated description from the Alliance of Genome Resources (Release 7.0.0)
Enables store-operated calcium channel activity. Involved in G protein-coupled receptor signaling pathway; ligand-gated ion channel signaling pathway; and positive regulation of insulin secretion. Acts upstream of or within calcium ion import; mammary gland epithelium development; and store-operated calcium entry. Located in basolateral plasma membrane. Part of protein-containing complex. Is active in plasma membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and skin. Human ortholog(s) of this gene implicated in immunodeficiency 9 and tubular aggregate myopathy 2. Orthologous to human ORAI1 (ORAI calcium release-activated calcium modulator 1).