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Sost Gene Detail
Summary
  • Symbol
    Sost
  • Name
    sclerostin
  • Synonyms
    5430411E23Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1921749
    NCBI Gene: 74499
  • Gene Overview
    MyGene.info: SOST
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:101962458-101967015 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 65.48 cM, cytoband D
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    45 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1921749
protein coding gene Chr11:101962458-101967015 (-)
129S1/SvImJ MGP_129S1SvImJ_G0019214
protein coding gene Chr11:104902790-104908480 (-)
A/J MGP_AJ_G0019182
protein coding gene Chr11:100472416-100477694 (-)
AKR/J MGP_AKRJ_G0019151
protein coding gene Chr11:103585693-103590244 (-)
BALB/cJ MGP_BALBcJ_G0019156
protein coding gene Chr11:100957806-100962363 (-)
C3H/HeJ MGP_C3HHeJ_G0018965
protein coding gene Chr11:103791350-103795911 (-)
C57BL/6NJ MGP_C57BL6NJ_G0019605
protein coding gene Chr11:108173210-108179169 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017231
protein coding gene Chr11:97897108-97901678 (-)
CAST/EiJ MGP_CASTEiJ_G0018519
protein coding gene Chr11:104755535-104760068 (-)
CBA/J MGP_CBAJ_G0018934
protein coding gene Chr11:112637654-112645492 (-)
DBA/2J MGP_DBA2J_G0019046
protein coding gene Chr11:99998479-100003217 (-)
FVB/NJ MGP_FVBNJ_G0019036
protein coding gene Chr11:99525226-99529843 (-)
LP/J MGP_LPJ_G0019115
protein coding gene Chr11:105420402-105425049 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0019067
protein coding gene Chr11:112167833-112172398 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0019643
protein coding gene Chr11:103944629-103951035 (-)
PWK/PhJ MGP_PWKPhJ_G0018282
protein coding gene Chr11:101057867-101062575 (-)
SPRET/EiJ MGP_SPRETEiJ_G0018074
protein coding gene Chr11:103689203-103693760 (-)
WSB/EiJ MGP_WSBEiJ_G0018568
protein coding gene Chr11:103932000-103937497 (-)



Homology
more
  • Human Ortholog
    SOST, sclerostin
  • Vertebrate Orthologs
    9
  • Human Ortholog
    SOST, sclerostin
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CDD, DAND6, SOST1, VBCH
  • Links
    NCBI Gene ID: 50964
    neXtProt AC: NX_Q9BQB4
    UniProt: Q9BQB4

  • Chr Location
    17q21.31; chr17:43753731-43758788 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    2 with Sost mouse models; 3 with human SOST associations

Human Disease Mouse Models
      
IDs
View 1 model
IDs
View 3 models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    3 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    30 phenotypes from 5 alleles in 5 genetic backgrounds
    19 phenotypes from multigenic genotypes
    1 images
    41 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit an increase in trabecular and cortical bone volume, mineral density, and formation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 74499 NCBI Gene Model | MGI Sequence Detail 4558 C57BL/6J ±  kb
    transcript NM_024449 RefSeq | MGI Sequence Detail 2066 C57BL/6  
    polypeptide Q99P68 UniProt | EBI | MGI Sequence Detail 211 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • PDB
    • InterPro Domains
      IPR029034 Cystine-knot cytokine
      IPR015665 Sclerostin
      IPR008835 Sclerostin/Sclerostin domain-containing protein 1
    Molecular
    Reagents
    less
    • All nucleic 9
      cDNA 7
      Other 2

      Microarray probesets 3
    References
    more
    • Summaries
      All 97
      Developmental Gene Expression 21
      Diseases 3
      Gene Ontology 9
      Phenotypes 41
    • Earliest
      J:56548 Zheng B, et al., Engineering a mouse balancer chromosome. Nat Genet. 1999 Aug;22(4):375-8
    • Latest
      J:261043 Chan WL, et al., Impaired proteoglycan glycosylation, elevated TGF-beta signaling, and abnormal osteoblast differentiation as the basis for bone fragility in a mouse model for gerodermia osteodysplastica. PLoS Genet. 2018 Mar;14(3):e1007242

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    12/04/2018
    MGI 6.13
    The Jackson Laboratory