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Sost
Gene Detail
Symbol

Name
ID
Sost
sclerostin
MGI:1921749
Synonyms
5430411E23Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 11
65.48 cM, cytoband D
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr11:101962458-101967015 bp, - strand
From VEGA annotation of GRCm38

  4558 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:11542  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

HCOP human homology predictions: SOST
Gene Tree: Sost

Human
homologs
SOST, sclerostin
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 50964
neXtProt AC: NX_Q9BQB4

Human Synonyms: CDD, SOST1, VBCH

Human Chr (Location): 17q11.2; chr17:43753731-43758788 (-)  GRCh38.p2

Disease Associations: (3) Diseases Associated with Human SOST

Mutations,
alleles, and
phenotypes
All mutations/alleles(13) : Targeted(12) Transgenic(1)
Genomic Mutations involving Sost (1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a null allele exhibit an increase in trabecular and cortical bone volume, mineral density, and formation.
 
Human Diseases Modeled in Mice Using Sost (2)    Mutations Annotated to Human Diseases (3)    Phenotype Images(1)
Interactions
Sost interacts with 144 markers (Mir7-1, Mir18, Mir18b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (15 records)
Data Summary: Results (80)    Tissues (74)    Images (12)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 30
RNA in situ 50
cDNA source data(6)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: ZFIN sost    NEW 
Molecular
reagents
All nucleic(8) cDNA(6) Other(2)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000002135 (Evidence)
Ensembl Gene Model ENSMUSG00000001494 (Evidence)
Entrez Gene 74499 (Evidence)
UniGene 265602
DFCI TC1747305, TC1620724, TC1590078
DoTS DT.55230813
NIA Mouse Gene Index U033459
PDB 2KD3
Consensus CDS Project CCDS25481.1
International Mouse Phenotyping Consortium Status Sost
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000002135 VEGA Gene Model | MGI Sequence Detail 4558 C57BL/6J ±  kb
transcript OTTMUST00000004344 VEGA | MGI Sequence Detail 2066 Not Applicable 
polypeptide OTTMUSP00000002060 VEGA | MGI Sequence Detail 211 Not Applicable 

For the selected sequences
All sequences(26) RefSeq(4) UniProt(2)
Polymorphisms
SNPs within 2kb(45 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR015665 Sclerostin
InterPro IPR008835 Sclerostin/Sclerostin domain-containing protein 1
Protein Ontology PR:000015415 sclerostin
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:218597 Morse A, et al., Endochondral fracture healing with external fixation in the Sost knockout mouse results in earlier fibrocartilage callus removal and increased bone volume fraction and strength. Bone. 2015 Feb;71:155-63
All references(63)
Disease annotation references (2)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory