Sost
Gene Detail

Symbol Name ID

Sost sclerostin MGI:1921749

Synonyms

5430411E23Rik

Feature Type

protein coding gene

Genetic Map

Chromosome 11

65.48 cM, cytoband D
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr11:101962458-101967015 bp, - strand From VEGA annotation of GRCm38   4558 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:11542  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Sost

Human homologs

Human Homolog		SOST, sclerostin
NCBI Gene ID		50964
neXtProt AC		NX_Q9BQB4
Human Synonyms		CDD, VBCH
Human Chr (Location)		17q11.2; chr17:41831099-41836156 (-)  GRCh37.p10
Disease Associations		(3) Diseases Associated with Human SOST

Alleles and phenotypes

All alleles(9) : Targeted(9)
 

Mice homozygous for a null allele exhibit an increase in trabecular and cortical bone volume, mineral density, and formation.

 
Human Diseases Modeled Using Mouse Sost (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (19 annotations)

Process	cellular response to parathyroid hormone stimulus, negative regulation of BMP signaling pathway, ...
Component	extracellular matrix, extracellular region, ...
Function	heparin binding, protein binding, ...

External Resources: FuncBase

Expression

Literature Summary: (12 records)
Data Summary: Results (40)    Tissues (35)   
Theiler Stages: 21, 22, 23, 24, 26, 28

Assay Type	Results
Immunohistochemistry	30
RNA in situ	10

cDNA source data(6)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(7) cDNA(6) Other(1)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000002135 (Evidence)
Ensembl Gene Model	ENSMUSG00000001494 (Evidence)
Entrez Gene	74499 (Evidence)
UniGene	265602
DFCI	TC1590078, TC1620724
DoTS	DT.55230813
NIA Mouse Gene Index	U033459
PDB	2KD3
Consensus CDS Project	CCDS25481.1
International Mouse Knockout Project Status	Sost

Sequences

Length	Strain/Species
genomic	OTTMUSG00000002135	VEGA Gene Model | MGI Sequence Detail	4558	C57BL/6J
transcript	OTTMUST00000004344	VEGA | MGI Sequence Detail	2066	Not Applicable
polypeptide	OTTMUSP00000002060	VEGA | MGI Sequence Detail	211	Not Applicable

All sequences(23) RefSeq(2) UniProt(3)

Polymorphisms

SNPs(9 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR015665	Sclerostin
InterPro	IPR008835	Sclerostin/Sclerostin domain-containing protein 1
Protein Ontology	PR:000015415	sclerostin

References

(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:190032 Bonnet N, et al., Regulation of beta catenin signaling and parathyroid hormone anabolic effects in bone by the matricellular protein periostin. Proc Natl Acad Sci U S A. 2012 Sep 11;109(37):15048-53
All references(52)