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Sost
Gene Detail
Symbol

Name
ID
Sost
sclerostin
MGI:1921749
Synonyms
5430411E23Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 11
65.48 cM, cytoband D
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr11:101962458-101967015 bp, - strand
From VEGA annotation of GRCm38

  4558 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:11542  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Sost

Human
homologs
Human Homolog SOST, sclerostin
NCBI Gene ID 50964
neXtProt AC  NX_Q9BQB4
Human Synonyms  CDD, SOST1, VBCH
Human Chr (Location)  17q11.2; chr17:43753731-43758788 (-)  GRCh38
Disease Associations  (3) Diseases Associated with Human SOST
Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Targeted(10)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null allele exhibit an increase in trabecular and cortical bone volume, mineral density, and formation.
 
Human Diseases Modeled Using Mouse Sost (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(1)
Interactions
Sost interacts with 145 markers (Mir7-1, Mir18, Mir18b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (13 records)
Data Summary: Results (80)    Tissues (74)    Images (12)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 30
RNA in situ 50
cDNA source data(6)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(8) cDNA(6) Other(2)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000002135 (Evidence)
Ensembl Gene ModelENSMUSG00000001494 (Evidence)
Entrez Gene74499 (Evidence)
UniGene265602
DFCITC1590078, TC1620724, TC1747305
DoTSDT.55230813
NIA Mouse Gene IndexU033459
PDB2KD3
Consensus CDS ProjectCCDS25481.1
International Mouse Knockout Project StatusSost
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000002135 VEGA Gene Model | MGI Sequence Detail 4558 C57BL/6J ±  kb
transcript OTTMUST00000004344 VEGA | MGI Sequence Detail 2066 Not Applicable 
polypeptide OTTMUSP00000002060 VEGA | MGI Sequence Detail 211 Not Applicable 

For the selected sequences
All sequences(26) RefSeq(4) UniProt(2)
Polymorphisms
SNPs within 2kb(45 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR015665 Sclerostin
InterPro IPR008835 Sclerostin/Sclerostin domain-containing protein 1
Protein Ontology PR:000015415 sclerostin
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:211503 McGee-Lawrence ME, et al., Sclerostin deficient mice rapidly heal bone defects by activating beta-catenin and increasing intramembranous ossification. Biochem Biophys Res Commun. 2013 Nov 29;441(4):886-90
All references(57)
Disease annotation references (1)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory