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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
Sost
sclerostin
MGI:1921749
33 phenotypes from 6 alleles in 6 genetic backgrounds
Export: Excel File
Allelic Composition
Genetic Background
Annotated Term Reference
Sosttm1(KOMP)Vlcg/Sosttm1(KOMP)Vlcg
involves: C57BL/6NTac
abnormal bone mineralization J:188586
abnormal bone ossification J:188586
abnormal osteoblast morphology J:188586
abnormal trabecular bone morphology J:188586
increased bone mass J:188586
increased bone trabecula number J:188586
increased compact bone area J:188586
increased trabecular bone connectivity density J:188586
increased trabecular bone volume J:188586
normal skeleton phenotype J:188586
Sosttm1(KOMP)Vlcg/Sosttm1(KOMP)Vlcg
involves: C57BL/6NTac
abnormal compact bone morphology J:167585
abnormal trabecular bone morphology J:167585
decreased osteocyte apoptosis J:167585
increased bone mass J:167585
increased bone mineral density of femur J:167585
increased bone mineral density of lumbar vertebrae J:167585
increased compact bone area J:167585
increased compact bone thickness J:167585
increased trabecular bone thickness J:167585
Sosttm1(KOMP)Vlcg/Sosttm1(KOMP)Vlcg
involves: C57BL/6NTac
increased bone mineral density J:200671
increased bone volume J:200671
increased compact bone thickness J:200671
Sosttm1(KOMP)Vlcg/Sosttm2.1Vlcg
Tg(Nanog-cre)#Vlcg/0
involves: 129S6/SvEvTac * C57BL/6NTac
increased bone mineral density J:200671
increased bone volume J:200671
increased compact bone thickness J:200671
Sosttm1Dgen/Sosttm1Dgen
involves: 129P2/OlaHsd * C57BL/6
abnormal bone ossification J:179873
decreased physiological sensitivity to xenobiotic J:179873
increased bone mass J:179873
increased bone mineral density J:179873
increased bone mineral density of lumbar vertebrae J:179873
increased compact bone thickness J:179873
Sosttm1Lex/Sosttm1Lex
involves: 129S5/SvEvBrd * C57BL/6
increased compact bone thickness J:274615
Sosttm1Lhe/Sosttm1Lhe
involves: C57BL/6J
abnormal bone remodeling J:168665
abnormal osteoblast morphology J:168665
abnormal osteoblast physiology J:168665
decreased osteoblast apoptosis J:168665
decreased osteocyte apoptosis J:168665
increased bone mass J:168665
increased bone mineral density J:168665
increased bone mineral density of femur J:168665
increased osteocyte number J:168665
Sosttm1Paz/Sosttm1Paz
involves: 129/Sv * Black Swiss
abnormal bone mineralization J:213541
abnormal bone ossification J:150166
abnormal osteoblast physiology J:150166
abnormal trabecular bone morphology J:150166
increased areal bone mineral density J:150166
increased body weight J:150166
increased bone mass J:213541
increased bone mineral content J:213541
increased bone mineral density J:150166, J:213541
increased bone mineral density of femur J:150166
increased bone stiffness J:213541
increased bone strength J:150166, J:213541
increased bone trabecula number J:150166
increased bone volume J:213541
increased compact bone area J:150166
increased compact bone mass J:213541
increased compact bone volume J:150166
increased trabecular bone mass J:213541
increased trabecular bone thickness J:150166
increased trabecular bone volume J:150166
long femur J:150166
Sosttm2.1Vlcg/Sosttm2.1Vlcg
involves: 129S6/SvEvTac * C57BL/6NTac
no abnormal phenotype detected J:200671

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/23/2024
MGI 6.23
The Jackson Laboratory