Sost^tm1Dgen
Targeted Allele Detail

Summary

• Symbol: Sost^tm1Dgen
• Name: sclerostin; targeted mutation 1, Deltagen
• MGI ID: MGI:5304482
• Gene: Sost Location: Chr11:101853284-101857841 bp, - strand Genetic Position: Chr11, 65.48 cM, cytoband D
• Alliance: Sost^tm1Dgen page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:179873
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129P2/OlaHsd
• Project Collection: Deltagen

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Most of the coding region is replaced with an IRES-lacZ-neo/kan cassette. The absence of expression was confirmed. (J:179873)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sost Mutation: 34 strains or lines available

References

• Original: J:179873 Kramer I, et al., Parathyroid hormone (PTH)-induced bone gain is blunted in SOST overexpressing and deficient mice. J Bone Miner Res. 2010 Feb;25(2):178-89
• All: 10 reference(s)